Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Kazuhide Nishimaru"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 92, Iss 4, Pp 424-427 (2003)
We examined the effect of Y-27632 ((+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclo-hexanecarboxamide), a selective Rho-associated kinase (ROCK) inhibitor, on agonist-induced inotropy in isolated mouse left atria. Endothelin-1, angiotensin-II, and p
Externí odkaz:
https://doaj.org/article/fb0e3566f92f4632a8bf30caba292bef
Publikováno v:
Journal of Pharmacological Sciences, Vol 92, Iss 3, Pp 196-202 (2003)
The intracellular signalling pathway for a-adrenoceptor-mediated negative inotropy was studied pharmacologically in isolated adult mouse ventricle. The negative inotropy was inhibited by GF-109203X, a nonselective protein kinase C inhibitor. Phorbol
Externí odkaz:
https://doaj.org/article/4f51995ed8324abcb6a9994f20cc318f
Autor:
Chul Hee Lee, Ashish Dhir, Katsushige Ono, Masahiko Tsujii, Yan Ping Zhao, Anthony Koller, Carlos Isaza, Guo Xin Cui, Xiao-Yun Yang, Shinji Miyamoto, Ti Jun Dai, Tohru Nakamura, Zheng-Tang Chen, Isil Ozakca, Motoko Yamabe, Gloria L. Porras, Ebru Arioglu, Shamarendra Sanyal, Jun-Hua Yuan, Marlyse Brawand, Bobby D. Nossaman, Hiroshi Eguchi, Yong Fei Tan, Patricia Digon, Zhi Jun Ge, Shuji Ishii, Julio C. Sánchez, Guo Jun Liu, Shinpei Fujiki, Chae-Seo Rhee, Tae-Bin Won, Tetsuo Hadama, Li Cai Zhang, Jian-Fei Gao, Yin Ming Zeng, Yan Guo, Christian Humpel, Shingo Tsuji, Mohammed M. Nazim, Séverine Crettol, S.K. Kulkarni, J. Cardona, Sunao Kawano, Si Whan Kim, Yang-Gi Min, Lisa C. Loram, Sahika Guner, Yong Min Kim, Philip J. Kadowitz, G. Bedoya, Albert L. Hyman, Hikaru Tanaka, Jun Wang, Karma V. Moser, Kazuhide Nishimaru, Tsutomu Nishida, Kerry Powell Golay, Julieta Henao, Shojirou Isomoto, Li Chang, Yujiro Hayashi, A. Tanju Ozcelikay, Paul R. Waldron, Yoshio Tanaka, Bi-Cheng Zhang, Koki Shigenobu, Yan-Qing Li, V.Melih Altan, Jun Ke Wang, Syed R. Baber, Chin B. Eap, Peter Kamerman
Publikováno v:
Pharmacology. 80:313-316
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::082f104d18a43717ea1d0dcc8bd6957b
https://doi.org/10.1159/000109845
https://doi.org/10.1159/000109845
Publikováno v:
Pharmacology. 80:200-206
Positive inotropy by sarcoplasmic/endoplasmic reticulum Ca2+ pump inhibitors was found and its mechanisms were analyzed pharmacologically. Thapsigargin and cyclopiazonic acid produced positive inotropy in isolated mouse left atria. The responses were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::360da7c101a3e7fbacb8f964da346a8d
https://doi.org/10.1159/000104417
https://doi.org/10.1159/000104417
Publikováno v:
The Journal of Physiology. 559:849-862
Large-conductance, voltage- and Ca2+-activated K+ channels (MaxiK, BK) are key regulators of vascular tone. Vascular MaxiK are formed by the pore-forming α subunit and the modulatory β1 subunit, which imprints unique kinetics, Ca2+/voltage sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9be70de64026fe0022dd55ca3e8297ea
https://doi.org/10.1113/jphysiol.2004.068676
https://doi.org/10.1113/jphysiol.2004.068676
Publikováno v:
Journal of Pharmacological Sciences, Vol 92, Iss 4, Pp 424-427 (2003)
We examined the effect of Y-27632 ((+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclo-hexanecarboxamide), a selective Rho-associated kinase (ROCK) inhibitor, on agonist-induced inotropy in isolated mouse left atria. Endothelin-1, angiotensin-II, and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bf2829a8b41e2ee8f49b4e89133db5
https://doi.org/10.1254/jphs.92.424
https://doi.org/10.1254/jphs.92.424
Publikováno v:
Vascular Pharmacology. 38:73-80
Cardiovascular disease remains the leading cause of death in the United States, and aging is one of the main risk factors for its development. Coronary arteries nurture the heart, but as age progresses, they suffer changes that make them stiffer, thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb496add5714d27b346a1bdc183d6733
https://doi.org/10.1016/s0306-3623(02)00128-3
https://doi.org/10.1016/s0306-3623(02)00128-3
Publikováno v:
Circulation Research. 88:210-216
Abstract —Aging is the main risk factor for coronary artery disease. One characteristic of aging coronary arteries is their enhanced contractile responses to endothelial vasoconstricting factors, which increase the risk of coronary vasospasm in old
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6feb0d48e4e70764d89983c597597343
https://doi.org/10.1161/01.res.88.2.210
https://doi.org/10.1161/01.res.88.2.210
Publikováno v:
Life Sciences. 66:607-615
Summary In isolated mouse left atria, acetylcholine (ACh) produced a biphasic inotropic response; a transient decrease in developed tension was followed by an increase. Both negative and positive responses were concentration dependent and were inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572a9f654d8867d0af1e4709754d8500
https://doi.org/10.1016/s0024-3205(99)00633-5
https://doi.org/10.1016/s0024-3205(99)00633-5
Autor:
Kazuhide Nishimaru, Koki Shigenobu, Toshiyuki Sekine, Hikaru Tanaka, Yoshio Tanaka, Hiromi Kusano
Publikováno v:
European Journal of Pharmacology. 374:411-415
Inotropic effects on isolated neonatal and adult mouse myocardium of endothelin I and angiotensin II were examined. Endothelin I produced a sustained positive inotropic response in the neonate but a sustained negative response in the adult. Both were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66860cf0025a1515a8d659deb7bf02c6
https://doi.org/10.1016/s0014-2999(99)00373-8
https://doi.org/10.1016/s0014-2999(99)00373-8