Zobrazeno 1 - 10
of 479
pro vyhledávání: '"Kazuhide Inoue"'
Autor:
Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Tetsuya Tamaru, Hirotaka Iura, Yohei Haruta, Kazuki Kitade, Keiichiro Iida, Kenichi Kawaguchi, Yoshihiro Matsumoto, Makoto Tsuda, Tomohiko Tamura, Keiko Ozato, Kazuhide Inoue, Dai-Jiro Konno, Takeshi Maeda, Seiji Okada, Yasuharu Nakashima
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract After spinal cord injury (SCI), inflammatory cells such as macrophages infiltrate the injured area, and astrocytes migrate, forming a glial scar around macrophages. The glial scar inhibits axonal regeneration, resulting in significant perman
Externí odkaz:
https://doaj.org/article/c01c6ce110314359af9cbddb6abc6d0f
Autor:
Kazuhide Inoue
Publikováno v:
Journal of Pharmacological Sciences, Vol 149, Iss 3, Pp 73-80 (2022)
Since new roles of nucleotides as neurotransmitters were proposed by Geoffrey Burnstock, the roles of ATP and P2 receptors (P2Rs) have been extensively studied in pain signaling. This review primarily focuses on the history and roles of P2X2Rs and P2
Externí odkaz:
https://doaj.org/article/d775722ad9a54f2e91f939a3b60219f5
Autor:
Chinatsu Shinozaki, Keita Kohno, Mitsunori Shiroishi, Daisuke Takahashi, Yu Yoshikawa, Yoshito Abe, Kenji Hamase, Makoto Nakakido, Kohei Tsumoto, Kazuhide Inoue, Makoto Tsuda, Tadashi Ueda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract We have recently developed a mouse monoclonal antibody (12–10H) binding to the head domain region in rat P2X4 receptor (rP2X4R, which is crucial for the pathogenesis of neuropathic pain) expressed on the cell with the highest binding affin
Externí odkaz:
https://doaj.org/article/56486021f0394e62b51df59f5de03618
Autor:
Masaya Yasui, Yuki Menjyo, Kyohei Tokizane, Akiko Shiozawa, Makoto Tsuda, Kazuhide Inoue, Hiroshi Kiyama
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Abstract Background Patients diagnosed with chronic fatigue syndrome (CFS) or fibromyalgia experience chronic pain. Concomitantly, the rat model of CFS exhibits microglial activation in the lumbar spinal cord and pain behavior without peripheral tiss
Externí odkaz:
https://doaj.org/article/edd0ccc5168d402fac4390ab0a4bb3f1
Publikováno v:
Molecules, Vol 27, Iss 6, p 1919 (2022)
Pain is an essential modality of sensation in the body. Purinergic signaling plays an important role in nociceptive pain transmission, under both physiological and pathophysiological conditions, and is important for communication between both neurona
Externí odkaz:
https://doaj.org/article/29bcd305992249dfb14f2809ef9aa507
Autor:
Tao Chen, Wataru Taniguchi, Qi-Yu Chen, Hidetoshi Tozaki-Saitoh, Qian Song, Ren-Hao Liu, Kohei Koga, Tsuyoshi Matsuda, Yae Kaito-Sugimura, Jian Wang, Zhi-Hua Li, Ya-Cheng Lu, Kazuhide Inoue, Makoto Tsuda, Yun-Qing Li, Terumasa Nakatsuka, Min Zhuo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
It is known that descending facilitation of spinal responses may contribute to chronic pain, however many studies have focussed on brainstem mechanisms. Here the authors show that stimulation of the anterior cingulate cortex increases excitatory tran
Externí odkaz:
https://doaj.org/article/cab2f802a1c14b699c2a653bbdddee93
Autor:
Kohei Yoshihara, Tsuyoshi Matsuda, Yuta Kohro, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Makoto Tsuda
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 1, Pp 101-104 (2018)
The role of astrocytes in the spinal dorsal horn (SDH) for sensory information processing under normal conditions is poorly understood. In this study, we investigated whether SDH astrocytes respond to noxious and innocuous stimuli to the skin of norm
Externí odkaz:
https://doaj.org/article/c2d7d4b6b81648098bf3c67ad249a335
Autor:
Keisuke Koga, Kensho Kanehisa, Yuta Kohro, Miho Shiratori-Hayashi, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Hidemasa Furue, Makoto Tsuda
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Inhibitory interneurons in the spinal dorsal horn (SDH) are crucial for processing somatosensory information originating in the periphery. However, the effects of the acute and selective inactivation of GABAergic SDH interneurons on pain pro
Externí odkaz:
https://doaj.org/article/4f4ee16c812b42aa90d3945ed4dec20e
Autor:
Tomohiro Yamashita, Sawako Kamikaseda, Aya Tanaka, Hidetoshi Tozaki-Saitoh, Jose M. M. Caaveiro, Kazuhide Inoue, Makoto Tsuda
Publikováno v:
Cells, Vol 10, Iss 2, p 434 (2021)
P2X7 receptors (P2X7Rs) belong to a family of ATP-gated non-selective cation channels. Microglia represent a major cell type expressing P2X7Rs. The activation of microglial P2X7Rs causes the release of pro-inflammatory cytokines such as interleukin-1
Externí odkaz:
https://doaj.org/article/e95dfc762571403cab85c132394811c9
Autor:
Naoya Matsunaga, Eriko Ikeda, Keisuke Kakimoto, Miyako Watanabe, Naoya Shindo, Akito Tsuruta, Hisako Ikeyama, Kengo Hamamura, Kazuhiro Higashi, Tomohiro Yamashita, Hideaki Kondo, Yuya Yoshida, Masaki Matsuda, Takashi Ogino, Kazutaka Tokushige, Kazufumi Itcho, Yoko Furuichi, Takaharu Nakao, Kaori Yasuda, Atsushi Doi, Toshiaki Amamoto, Hironori Aramaki, Makoto Tsuda, Kazuhide Inoue, Akio Ojida, Satoru Koyanagi, Shigehiro Ohdo
Publikováno v:
EBioMedicine, Vol 13, Iss C, Pp 262-273 (2016)
Chronic kidney disease (CKD) is a global health problem, and novel therapies to treat CKD are urgently needed. Here, we show that inhibition of G0/G1 switch 2 (G0s2) ameliorates renal inflammation in a mouse model of CKD. Renal expression of chemokin
Externí odkaz:
https://doaj.org/article/78a7228c8a9c43ea90380dcc86ba6101