Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kazuharu Hanada"'
Autor:
Chunlai Tam, Mutsuko Kukimoto-Niino, Yukako Miyata-Yabuki, Kengo Tsuda, Chiemi Mishima-Tsumagari, Kentaro Ihara, Mio Inoue, Mayumi Yonemochi, Kazuharu Hanada, Takehisa Matsumoto, Mikako Shirouzu, Kam Y. J. Zhang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Structural analysis of the Ras-binding domain (RBD) of ELMO1 alone and in complex with the activator RhoG enables rational engineering and validation of a nanobody targeting ELMO1 RBD.
Externí odkaz:
https://doaj.org/article/57ffcbf5665046feb62686a925bac3cb
Autor:
Masaru Takeshita, Hidehiro Fukuyama, Katsuhiko Kamada, Takehisa Matsumoto, Chieko Makino-Okamura, Qingshun Lin, Machie Sakuma, Eiki Kawahara, Isato Yamazaki, Tomomi Uchikubo-Kamo, Yuri Tomabechi, Kazuharu Hanada, Tamao Hisano, Saya Moriyama, Yoshimasa Takahashi, Mutsumi Ito, Masaki Imai, Tadashi Maemura, Yuri Furusawa, Seiya Yamayoshi, Yoshihiro Kawaoka, Mikako Shirouzu, Makoto Ishii, Hideyuki Saya, Yasushi Kondo, Yuko Kaneko, Katsuya Suzuki, Koichi Fukunaga, Tsutomu Takeuchi
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106955- (2023)
Summary: Several antibody therapeutics have been developed against SARS-CoV-2; however, they have attenuated neutralizing ability against variants. In this study, we generated multiple broadly neutralizing antibodies from B cells of convalescents, by
Externí odkaz:
https://doaj.org/article/e2e3c31b08ae483eaf9d68617811b2ec
Autor:
Tomomi Kimura‐Someya, Miyuki Kato‐Murayama, Kazushige Katsura, Naoki Sakai, Kazutaka Murayama, Kazuharu Hanada, Mikako Shirouzu, Yuichi Someya
Publikováno v:
FEBS Open Bio, Vol 12, Iss 3, Pp 560-570 (2022)
Noroviruses have been identified as major causative agents of acute nonbacterial gastroenteritis in humans. Histo‐blood group antigens (HBGAs) are thought to play a major role among the host cellular factors influencing norovirus infection. Genogro
Externí odkaz:
https://doaj.org/article/334a8259cabc477988a84d5eff4e10d4
Autor:
Masaru Takeshita, Hidehiro Fukuyama, Katsuhiko Kamada, Takehisa Matsumoto, Chieko Makino-Okamura, Tomomi Uchikubo-Kamo, Yuri Tomabechi, Kazuharu Hanada, Saya Moriyama, Yoshimasa Takahashi, Hirohito Ishigaki, Misako Nakayama, Cong Thanh Nguyen, Yoshinori Kitagawa, Yasushi Itoh, Masaki Imai, Tadashi Maemura, Yuri Furusawa, Hiroshi Ueki, Kiyoko Iwatsuki-Horimoto, Mutsumi Ito, Seiya Yamayoshi, Yoshihiro Kawaoka, Mikako Shirouzu, Makoto Ishii, Hideyuki Saya, Yasushi Kondo, Yuko Kaneko, Katsuya Suzuki, Koichi Fukunaga, Tsutomu Takeuchi
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105596- (2022)
Summary: The use of therapeutic neutralizing antibodies against SARS-CoV-2 infection has been highly effective. However, there remain few practical antibodies against viruses that are acquiring mutations. In this study, we created 494 monoclonal anti
Externí odkaz:
https://doaj.org/article/e7753cf4b9224024873cebd24a1bbb2e
Autor:
Toshiaki Hosaka, Kazushige Katsura, Yoshiko Ishizuka-Katsura, Kazuharu Hanada, Kaori Ito, Yuri Tomabechi, Mio Inoue, Ryogo Akasaka, Chie Takemoto, Mikako Shirouzu
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10399 (2022)
Genetically encoded caged amino acids can be used to control the dynamics of protein activities and cellular localization in response to external cues. In the present study, we revealed the structural basis for the recognition of O-(2-nitrobenzyl)-L-
Externí odkaz:
https://doaj.org/article/1b21cd4106cd40cea6fb37e78572ec8c
Autor:
K V, Dileep, Kentaro, Ihara, Chiemi, Mishima-Tsumagari, Mutsuko, Kukimoto-Niino, Mayumi, Yonemochi, Kazuharu, Hanada, Mikako, Shirouzu, Kam Y J, Zhang
Publikováno v:
International Journal of Biological Macromolecules. 210:172-181
Alzheimer's disease (AD) is one of the most common, progressive neurodegenerative disorders affecting the aged populations. Though various disease pathologies have been suggested for AD, the impairment of the cholinergic system is one of the critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b72c72b1fc23f0549a6412fa7158e98
https://doi.org/10.1016/j.ijbiomac.2022.05.009
https://doi.org/10.1016/j.ijbiomac.2022.05.009
Autor:
Masaki Kikuchi, Satoshi Morita, Mie Goto, Masatoshi Wakamori, Kazushige Katsura, Kazuharu Hanada, Mikako Shirouzu, Takashi Umehara
Publikováno v:
The Journal of biological chemistry. 298(8)
Acetylated lysine residues (Kac) in histones are recognized by epigenetic reader proteins, such as Yaf9, ENL, AF9, Taf14, and Sas5 (YEATS) domain-containing proteins. Human YEATS domains bind to the acetylated N-terminal tail of histone H3; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cf65c1c332ecaca6c0db548d7a77da
https://pubmed.ncbi.nlm.nih.gov/35732209
https://pubmed.ncbi.nlm.nih.gov/35732209
Autor:
Mutsuko Kukimoto-Niino, Mikako Shirouzu, Tomomi Uchikubo-Kamo, Haruhiko Ehara, Takeshi Yokoyama, Kazuharu Hanada, Kam Y. J. Zhang, Kazushige Katsura, Chiemi Mishima-Tsumagari, Mariko Ikeda, Rahul Kaushik, Mayumi Yonemochi, Reiko Nakagawa
Publikováno v:
Science Advances
Rac1-bound structure and mutagenesis of the ELMO1-DOCK5 complex provide insights into how ELMO modulates DOCK activity.
The dedicator of cytokinesis (DOCK) family of guanine nucleotide exchange factors (GEFs) promotes cell motility, phagocytosis
The dedicator of cytokinesis (DOCK) family of guanine nucleotide exchange factors (GEFs) promotes cell motility, phagocytosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b5e6f4b2c3282d594cd143e8506e95
http://europepmc.org/articles/PMC8294757
http://europepmc.org/articles/PMC8294757
Autor:
Roman Belle, Kazuharu Hanada, Kosuke Nishio, Noboru Ohsawa, Hiroaki Suga, Takayuki Katoh, Akane Kawamura, Mikako Shirouzu, Toru Sengoku, Shigeyuki Yokoyama
Publikováno v:
ChemBioChem
The ten-eleven translocation (TET) protein family, consisting of three isoforms (TET1/2/3), have been found in mammalian cells and have a crucial role in 5-methylcytosine demethylation in genomic DNA through the catalysis of oxidation reactions assis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfef23544b0eb4396de23046d4e39f0b
https://doi.org/10.1002/cbic.201800047
https://doi.org/10.1002/cbic.201800047
Publikováno v:
Biochemical Journal
Really interesting new gene (RING)-finger protein 52 (RNF52), an E3 ubiquitin ligase, is found in eukaryotes from yeast to humans. Human RNF52 is known as breast cancer type 1 susceptibility protein (BRCA1)-associated protein 2 (BRAP or BRAP2). The c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a5c8acf20ada305e751f74acdb1334
https://doi.org/10.1042/bcj20161104
https://doi.org/10.1042/bcj20161104