Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Kazufumi Toume"'
Autor:
Yuki Tayama, Shusaku Mizukami, Kazufumi Toume, Katsuko Komatsu, Tetsuo Yanagi, Takeshi Nara, Paul Tieu, Nguyen Tien Huy, Shinjiro Hamano, Kenji Hirayama
Publikováno v:
Tropical Medicine and Health, Vol 51, Iss 1, Pp 1-12 (2023)
Abstract Background Current therapeutic agents, including nifurtimox and benznidazole, are not sufficiently effective in the chronic phase of Trypanosoma cruzi infection and are accompanied by various side effects. In this study, 120 kinds of extract
Externí odkaz:
https://doaj.org/article/370c70bf44ab45399f76ef65c49a72ab
Autor:
Ryota Araki, Hayato Tachioka, Ayami Kita, Hironori Fujiwara, Kazufumi Toume, Kinzo Matsumoto, Takeshi Yabe
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 11, Iss 6, Pp 513-519 (2021)
Kihito (KIT; Gui Pi Tang) is a traditional herbal medicine that is used for treatment of neuropsychiatric disorders such as depression, anxiety, neurosis and insomnia in China and Japan. Recently, it has also been shown that KIT improves cognitive dy
Externí odkaz:
https://doaj.org/article/a88ad20a4b7044bab850f22623f1b748
Autor:
Awet Alem Teklemichael, Shusaku Mizukami, Kazufumi Toume, Farhana Mosaddeque, Mohamed Gomaa Kamel, Osamu Kaneko, Katsuko Komatsu, Juntra Karbwang, Nguyen Tien Huy, Kenji Hirayama
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-10 (2020)
Abstract Background Herbal medicine has been a rich source of new drugs exemplified by quinine and artemisinin. In this study, a variety of Japanese traditional herbal medicine (‘Kampo’) were examined for their potential anti-malarial activities.
Externí odkaz:
https://doaj.org/article/6872711f038842548071e6b89af50f2a
Autor:
Yasunari Yamada, Hodaka Saito, Masaya Araki, Yuhei Tsuchimoto, Shin-ichi Muroi, Kyohei Suzuki, Kazufumi Toume, Jun-Dal Kim, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano, Yoshimi Nakagawa
Publikováno v:
Nutrients, Vol 14, Iss 19, p 3920 (2022)
Fibroblast growth factor 21 (FGF21), which is mainly synthesized and secreted by the liver, plays a crucial role in systemic glucose and lipid metabolism, ameliorating metabolic diseases. In this study, we screened the WAKANYAKU library derived from
Externí odkaz:
https://doaj.org/article/5d60c96dc6654c8aa7ab1611216b7918
Autor:
Yosuke Hiraki, Ryota Araki, Hironori Fujiwara, Yukio Ago, Tatsunori Tanaka, Kazufumi Toume, Kinzo Matsumoto, Takeshi Yabe
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 2, Pp 72-76 (2019)
Kamiuntanto (KUT; Jia Wei Wen Dan Tang in Pinyin) is a traditional Japanese Kampo medicine that is used to treat psychological dysfunction. However, the mechanisms of action of KUT are not understood. To investigate the mechanisms underlying the amel
Externí odkaz:
https://doaj.org/article/4beb4b86392d457d93fc61d61658c2c9
Autor:
Zitai Wang, Kayu Okutsu, Taiki Futagami, Yumiko Yoshizaki, Hisanori Tamaki, Takuro Maruyama, Kazufumi Toume, Katsuko Komatsu, Fumio Hashimoto, Kazunori Takamine
Publikováno v:
Frontiers in Nutrition, Vol 7 (2020)
Shinkiku (Massa Medicata Fermentata) is a traditional crude drug used to treat anorexia and dyspepsia of elder patients in east Asia. Shinkiku is generally prepared by the microbial fermentation of wheat and herbs. Shinkiku is also used in Japanese K
Externí odkaz:
https://doaj.org/article/506f4f16f2a647f19b011c73db1ffb96
Autor:
Qing-Yun Guo, Ken Ebihara, Takafumi Shimodaira, Hironori Fujiwara, Kazufumi Toume, Dya Fita Dibwe, Suresh Awale, Ryota Araki, Takeshi Yabe, Kinzo Matsumoto
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211266 (2019)
Dysfunctions in the GABAergic system are associated with the pathogenesis of autism spectrum disorder (ASD). However, the mechanisms by which GABAergic system dysfunctions induce the pathophysiology of ASD remain unclear. We previously demonstrated t
Externí odkaz:
https://doaj.org/article/b90fe8d48ae9479e803bea6ff07dcf84
Autor:
Tsugunobu Andoh, Mitsuru Kato, Ryo Kitamura, Shizuka Mizoguchi, Daisuke Uta, Kazufumi Toume, Katsuko Komatsu, Yasushi Kuraishi
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 6, Iss 3, Pp 305-308 (2016)
The chemotherapeutic agent paclitaxel (PTX) causes peripheral neuropathy as a major dose-limiting side effect, and this peripheral neuropathy is difficult to control. Our previous report showed that prophylactic repetitive administration of goshajink
Externí odkaz:
https://doaj.org/article/c27415c8b06c4961b0ffc313eb2187a9
Hirsutine, an Indole Alkaloid of Uncaria rhynchophylla, Inhibits Late Step in Dengue Virus Lifecycle
Autor:
Takayuki Hishiki, Fumihiro Kato, Shigeru Tajima, Kazufumi Toume, Masahito Umezaki, Tomohiko Takasaki, Tomoyuki Miura
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Dengue virus (DENV) is transmitted to humans by Aedes mosquitoes and is a public health issue worldwide. No antiviral drugs specific for treating dengue infection are currently available. To identify novel DENV inhibitors, we analyzed a library of 95
Externí odkaz:
https://doaj.org/article/e3c6cd2dcd064ce49f7e2d1bc12f8226
Publikováno v:
Marine Drugs, Vol 12, Iss 6, Pp 3466-3476 (2014)
A biological screening study of an actinomycetes strain assembly was conducted using a cell-based cytotoxicity assay. The CKK1019 strain was isolated from a sea sand sample. Cytotoxicity-guided fractionation of the CKK1019 strain culture broth, which
Externí odkaz:
https://doaj.org/article/8e0a81c38f394f78a45f326943fa015b