Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kazuaki Niikura"'
Publikováno v:
European Journal of Pharmaceutical Sciences. 96:551-559
Neuropathic pain patients are characterized by evoked pain (hyperalgesia and allodynia) and spontaneous pain, the latter of which is the predominant symptom. In animal models of neuropathic pain, effects of test compounds on spontaneous pain-related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ab6f77219f2298f1e7cceb156aa6d2
https://doi.org/10.1016/j.ejps.2016.10.037
https://doi.org/10.1016/j.ejps.2016.10.037
Publikováno v:
Bone. 40:888-894
There is considerable evidence that osteoclasts are involved in the pathogenesis of juxta-articular bone destruction in rheumatoid arthritis. Vacuolar ATPases (V-ATPases), which are highly expressed in the ruffled border membrane of osteoclasts, play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321c75460d2757c69a9f9d64f3b54ac9
https://doi.org/10.1016/j.bone.2006.10.015
https://doi.org/10.1016/j.bone.2006.10.015
Autor:
Ok Pyo Zee, Ikuo Morita, Kenji Ishihara, JangJa Hong, Kazuo Ohuchi, Ken-ichi Nakahama, Aya Yokomakura, Mitsue Onodera, Yasuhiro Nakano, Makoto Kaneda, Jong-Woong Ahn, Kazuaki Niikura
Publikováno v:
FEBS Letters. 580:2723-2730
Apicularen A and the known vacuolar-type (H(+))-ATPase (V-ATPase) inhibitor bafilomycin A(1) induced apoptosis of RAW 264.7 cells, while apicularen B, an N-acetyl-glucosamine glycoside of apicularen A, was far less effective. Apicularen A inhibited v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae73d7e6f304fea0334c9298d8bfa596
https://doi.org/10.1016/j.febslet.2006.04.031
https://doi.org/10.1016/j.febslet.2006.04.031
Publikováno v:
The Journal of Toxicological Sciences. 30:297-304
An acidic microenvironment formed by vacuolar ATPase (V-ATPase) expressed in plasma membranes of osteoclasts is thought to be indispensable for bone resorption. This study examined the efficacy of a novel V-ATPase inhibitor, FR202126, in reducing alv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95718b83692435197deac5690fc05766
https://doi.org/10.2131/jts.30.297
https://doi.org/10.2131/jts.30.297
Publikováno v:
British Journal of Pharmacology. 142:558-566
1 Vacuolar ATPase (V-ATPase) has been proposed as a drug target in lytic bone diseases. Studies of bafilomycin derivatives suggest that the key issue regarding the therapeutic usefulness of V-ATPase inhibitors is selective inhibition of osteoclast V-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2f79ab92aa81f37b8aec1d890548656
https://doi.org/10.1038/sj.bjp.0705812
https://doi.org/10.1038/sj.bjp.0705812
Autor:
Young-Sook Kang, Ok Pyo Zee, Yasuhiro Nakano, Maiko Yanai, Noriyasu Hirasawa, Kenji Ishihara, Aya Yokomakura, Jong Hwan Kwak, Jang Ja Hong, Kazuaki Niikura, Hirokazu Sasaki, Kazuo Ohuchi, Joa Sub Oh
Publikováno v:
Planta Medica. 73:173-175
Apicularens A and B were isolated from the myxobacterial genus Chondromyces apiculatus JW184. Apicularen A inhibited bafilomycin A1-sensitive ATP-dependent proton transport into microsome vesicles more potently than apicularen B. Bone resorption in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c329444c250fd1820025578681dc862
https://doi.org/10.1055/s-2006-957069
https://doi.org/10.1055/s-2006-957069
Autor:
Kazuaki Niikura
Publikováno v:
Cancer chemotherapy and pharmacology. 60(4)
It has been demonstrated that vacuolar ATPase (V-ATPase) is involved in various aspects of bone metastasis. The aim of this study is to investigate the effect of the anti-bone resorptive activity of the V-ATPase inhibitor FR202126 on bone metastases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e41e430147eab9b96d710d6d7a2b95c
https://pubmed.ncbi.nlm.nih.gov/17187252
https://pubmed.ncbi.nlm.nih.gov/17187252
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 20(9)
FR167356, a novel inhibitor of vacuolar ATPase, has high potency against osteoclast V-ATPase and low potency against lysosomal V-ATPase. FR167356 is the first compound of this nature to be tested. It has the potential to be useful for clinical applic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8caa1e71766884d29594ecb4980a3aba
https://pubmed.ncbi.nlm.nih.gov/16059630
https://pubmed.ncbi.nlm.nih.gov/16059630
Publikováno v:
British journal of pharmacology. 142(3)
1 Vacuolar ATPase (V-ATPase) has been proposed as a drug target in lytic bone diseases. Studies of bafilomycin derivatives suggest that the key issue regarding the therapeutic usefulness of V-ATPase inhibitors is selective inhibition of osteoclast V-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0af4b1a82e8d1aeeac220c1c45660c84
https://pubmed.ncbi.nlm.nih.gov/15148249
https://pubmed.ncbi.nlm.nih.gov/15148249
Autor:
Kazuaki Niikura
Publikováno v:
Drug News & Perspectives. 19:139
Vacuolar ATPases (V-ATPases) are present not only in the plasma membranes of specialized cells but also in ubiquitous intracellular acidic compartments, which are essential for physiological cellular function. Consequently, although V-ATPases are imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74fbb24cf0bca3df916a68fb8e0b2a5
https://doi.org/10.1358/dnp.2006.19.3.977442
https://doi.org/10.1358/dnp.2006.19.3.977442