Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Kazuaki Kakehi"'
Autor:
Toru Hiratsuka, Shinsuke Matsuzaki, Shingo Miyata, Mitsuhiro Kinoshita, Kazuaki Kakehi, Shinji Nishida, Taiichi Katayama, Masaya Tohyama
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13280 (2010)
BackgroundRecently, several studies have reported Yokukansan (Tsumura TJ-54), a traditional Japanese medicine, as a potential new drug for the treatment of Alzheimer's disease (AD). Endoplasmic reticulum (ER) stress is known to play an important role
Externí odkaz:
https://doaj.org/article/9199ae2f7a49460da6d55aded088de7d
Autor:
Susumu Honda, Kazuaki Kakehi
Publikováno v:
Analysis of Carbohydrates by GLC and MS ISBN: 9781003068556
Analysis of Carbohydrates by GLC and MS
Analysis of Carbohydrates by GLC and MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eb9f4f3da8343e3a73221050e733356
https://doi.org/10.1201/9781003068556-4
https://doi.org/10.1201/9781003068556-4
Autor:
Koichiro Teshima, Shigeo Suzuki, Chiemi Matsumura, Mitsuhiro Kinoshita, Hideaki Yamada, Takashi Hiroshima, Keita Yamada, Kazuaki Kakehi
Publikováno v:
ELECTROPHORESIS. 38:1344-1352
mAbs are currently mainstream in biopharmaceuticals, and their market has been growing due to their high target specificity. Characterization of heterogeneities in mAbs is performed to secure their quality and safety by physicochemical analyses. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c511a6f938591be96b9d8c527e6d0b
https://doi.org/10.1002/elps.201700014
https://doi.org/10.1002/elps.201700014
Autor:
Toshiki Inoue, Soichiro Kita, Kazuo Sei, Kazuaki Kakehi, Motonori Aoshima, Keita Yamada, Kiyotaka Hasegawa, Yoshio Jo, Mitsuhiro Kinoshita
Publikováno v:
YAKUGAKU ZASSHI. 134:1209-1217
Carboxymethyl cellulose (CMC) is one of the most important cellulose derivatives and used in the fields of food, pharmaceuticals, cosmetics, and paint. Fibrous CMC is used an antiadhesive material to prevent postoperative wound adhesions. The degree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d7eee4f7501476fd599851250b0f1c
https://doi.org/10.1248/yakushi.14-00174
https://doi.org/10.1248/yakushi.14-00174
Autor:
Katsuhiro Inada, Kazuaki Kakehi, Mitsuhiro Kinoshita, Kinya Iwatsuka, Shinichi Yasueda, Hiroki Iwamoto
Publikováno v:
Current Eye Research. 39:686-694
We compared cultured Statens Seruminstitut rabbit cornea (SIRC) cells and corneal epithelial cells from rabbit eyes by analyzing their N-glycans and glycosaminoglycans (GAGs). This work is a fundamental study on the efficacy of using cultured cells i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b22188b854eb088e65edf06fc0cf950
https://doi.org/10.3109/02713683.2013.863940
https://doi.org/10.3109/02713683.2013.863940
Autor:
Naoko Yamaguchi, Takao Hayakawa, Mana Nagata, Natsumi Ikeda, Shigeo Suzuki, Noriaki Nishida, Kazuaki Kakehi, Masahiro Yodoshi
Publikováno v:
ELECTROPHORESIS. 34:3198-3205
We have identified novel CE conditions for the separation of 7-amino-4-methylcoumarin-labeled monosaccharides and oligosaccharides from glycoproteins. Using a neutrally coated capillary and alkaline borate buffer containing hydroxypropylcellulose and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285a7ef9b9b959c211b03e506e4d3cdd
https://doi.org/10.1002/elps.201200612
https://doi.org/10.1002/elps.201200612
Publikováno v:
Journal of Chromatography A. 1309:76-83
Monoclonal antibody (mAb) pharmaceuticals are much more complex than small-molecule drugs. Such complex characteristics raise challenging questions for regulatory evaluation. Although heterogeneity in mAbs based on their charge variants has been main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0760d0b427cfbca9902a0e5542419963
https://doi.org/10.1016/j.chroma.2013.08.021
https://doi.org/10.1016/j.chroma.2013.08.021
Autor:
Hiroaki Waki, Akemi Suzuki, Kozo Miseki, Kazuaki Kakehi, Takashi Shimada, Taka-Aki Sato, Minoru Suzuki, Emi Ito
Publikováno v:
Glycoconjugate Journal. 30:881-888
Four types of neutral glycosphingolipids (LacCer, Gb3Cer, Gb4Cer, and IV3αGalNAc-Gb4Cer; 10 pmol each) were analyzed using high-performance liquid chromatography (HPLC)-electrospray ionization quadrupole ion trap time-of-flight (ESI-QIT-TOF) mass sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e471a7e88c578d3cc3323906da4973
https://doi.org/10.1007/s10719-013-9492-8
https://doi.org/10.1007/s10719-013-9492-8
Autor:
Keita Yamada, Mitsuhiro Kinoshita, Takao Hayakawa, Kazuaki Kakehi, Kazuya Kamisue, Tadashi Suzuki, Sakie Watanabe, Kinya Iwatsuka
Publikováno v:
Journal of Chromatography B. 928:16-21
During the course of studies on the analysis of O-glycans in biological samples, we found that significant amount of free glycans are present in normal human serum samples. The most abundant free glycan was disialo-biantennary glycan typically observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f6359b3c0d2c5e434b27023da7a088
https://doi.org/10.1016/j.jchromb.2013.03.010
https://doi.org/10.1016/j.jchromb.2013.03.010
Publikováno v:
Analytical Chemistry. 85:3325-3333
A method is proposed for the analysis of O-glycans as 9-fluorenylmethyl (Fmoc) derivatives. After releasing the O-glycans from the protein backbone in the presence of ammonia-based media, the glycosylamines thus formed are conveniently labeled with F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d29073d177d524fea2730f50b9ce225
https://doi.org/10.1021/ac303771q
https://doi.org/10.1021/ac303771q