Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kazuaki Hoshi"'
Autor:
Motoyasu Kato, Shinichi Sasaki, Wataru Mori, Makiko Kohmaru, Takashi Akimoto, Eri Hayakawa, Soichiro Soma, Yuta Arai, Naho Sakamoto Matsubara, Shun Nakazawa, Takuto Sueyasu, Haruki Hirakawa, Hiroaki Motomura, Issei Sumiyoshi, Yusuke Ochi, Junko Watanabe, Kazuaki Hoshi, Kotaro Kadoya, Hiroaki Ihara, Jia Hou, Shinsaku Togo, Kazuhisa Takahashi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Nintedanib reduces the decline in forced vital capacity and extends the time to the first acute exacerbation of interstitial lung disease (AE-ILD). However, the effect of additional nintedanib administration after AE-ILD onset is unknown. Th
Externí odkaz:
https://doaj.org/article/587c80b588144d24abb939be5c3de443
Autor:
Fika Ayu Safitri, Anh Thi Tram Tu, Kazuaki Hoshi, Miwako Shobo, Dandan Zhao, Arief Budi Witarto, Sony Heru Sumarsono, Ernawati Arifin Giri-Rachman, Kaori Tsukakoshi, Kazunori Ikebukuro, Tomohiko Yamazaki
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1617 (2021)
Guanine-quadruplex-based CpG oligodeoxynucleotides (G4 CpG ODNs) have been developed as potent immunostimulatory agents with reduced sensitivity to nucleases. We designed new monomeric G4 ODNs with an antiparallel topology using antiparallel type dup
Externí odkaz:
https://doaj.org/article/0cb9662d3dce41ee8d9804a7db7436e6
Publikováno v:
Biomedical Research and Therapy. 9:5410-5417
Autor:
Anh Thi Tram Tu, Kazuaki Hoshi, Yue Ma, Taiji Oyama, Satoko Suzuki, Kaori Tsukakoshi, Kazuo Nagasawa, Kazunori Ikebukuro, Tomohiko Yamazaki
Publikováno v:
ACS Chemical Biology. 17:1703-1713
We previously reported that the formation of guanine-quadruplex (G4) structures provides phosphodiester oligodeoxynucleotides containing unmethylated cytosine-phosphate-guanine (CpG ODNs) with higher nuclease resistance and cellular uptake, thereby i
Publikováno v:
Biomacromolecules. 21:3644-3657
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated cytosine-phosphate-guanine (CpG) motifs trigger the immune response by stimulating endosomal Toll-like receptor (TLR) 9. Natural linear ODNs are susceptible to nuclease degradation, there
Autor:
Yuuki Sugiyama, Wakako Tsugawa, Koji Sode, Kaori Tsukakoshi, Tomohiko Yamazaki, Kazunori Ikebukuro, Kazuaki Hoshi
Publikováno v:
Nucleic Acid Therapeutics. 29:224-229
Single-strand oligodeoxynucleotides (ODNs) containing unmethylated cytosine-phosphate-guanine (CpG) are recognized by the toll-like receptor 9, a component of the innate immunity. Therefore, they could act as immunotherapeutic agents. Chemically modi
Autor:
Kazunori Ikebukuro, Kaori Tsukakoshi, Tomohiko Yamazaki, Anh Thi Tram Tu, Fika Ayu Safitri, Arief Budi Witarto, Dandan Zhao, Ernawati Arifin Giri-Rachman, Miwako Shobo, Sony Heru Sumarsono, Kazuaki Hoshi
Publikováno v:
Biomolecules
Biomolecules, Vol 11, Iss 1617, p 1617 (2021)
Volume 11
Issue 11
Biomolecules, Vol 11, Iss 1617, p 1617 (2021)
Volume 11
Issue 11
Guanine-quadruplex-based CpG oligodeoxynucleotides (G4 CpG ODNs) have been developed as potent immunostimulatory agents with reduced sensitivity to nucleases. We designed new monomeric G4 ODNs with an antiparallel topology using antiparallel type dup
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 40
Guanine-quadruplex (G4) oligodeoxynucleotides (ODNs) that contain unmethylated cytosine-phosphate-guanine motifs (G4 CpG ODN) with phosphodiester backbones are safer than the phosphorothioate (PT)-modified CpG ODNs recently used as vaccine adjuvants.
Autor:
Koji Sode, Kazuaki Hoshi, Chiaki Yoshikawa, Wakako Tsugawa, Tomohiko Yamazaki, Kazunori Ikebukuro
Publikováno v:
International Journal of Nanomedicine
Kazuaki Hoshi,1 Tomohiko Yamazaki,2 Chiaki Yoshikawa,3 Wakako Tsugawa,1 Kazunori Ikebukuro,1 Koji Sode1,4 1Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture & Technology, Koganei, Tokyo, Jap
Publikováno v:
Solid State Sciences. 17:28-34
A Cu–Al layered double hydroxide intercalated with ethylenediaminetetraacetate (edta•Cu–Al LDH) was prepared by the dropwise addition of a Cu–Al nitrate solution to an edta solution at constant pH values of 8.0, 9.0, and 10.0. The edta•Cu