Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kazuaki, Takami"'
Autor:
Yuta Tanaka, Masaki Seto, Keiko Kakegawa, Kazuaki Takami, Fumiaki Kikuchi, Takeshi Yamamoto, Minoru Nakamura, Masaki Daini, Masataka Murakami, Tomohiro Ohashi, Takahito Kasahara, Junsi Wang, Zenichi Ikeda, Yasufumi Wada, Florian Puenner, Takahiro Fujii, Masakazu Inazuka, Sho Sato, Tomohiko Suzaki, Jeong-Ho Oak, Yuichi Takai, Hiroshi Kohara, Kouya Kimoto, Hideyuki Oki, Satoshi Mikami, Minoru Sasaki
Publikováno v:
Journal of Medicinal Chemistry. 65:4270-4290
Inhibition of glucosylceramide synthase (GCS) is a major therapeutic strategy for Gaucher's disease and has been suggested as a potential target for treating Parkinson's disease. Herein, we report the discovery of novel brain-penetrant GCS inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a407ff68d50cb206d4c182ef36b2c1cf
https://doi.org/10.1021/acs.jmedchem.1c02078
https://doi.org/10.1021/acs.jmedchem.1c02078
Autor:
Ryo Ito, Yoshitomi Yayoi, Koji Watanabe, Teruki Hamada, Yasuhiro Hirata, Yasufumi Miyamoto, Seiji Miwatashi, Nobuyuki Takakura, Kazuaki Takami, Yoshihiko Hirozane, Naoyoshi Noguchi, Yusuke Moritoh, Mitsugi Ookawara, Hideki Furukawa, Jumpei Aida, Masanori Watanabe, Hitomi Yuko, Tsuyoshi Maekawa
Publikováno v:
Journal of Medicinal Chemistry. 63:10352-10379
GPR40/FFAR1 is a G-protein-coupled receptor expressed in pancreatic β-cells and enteroendocrine cells. GPR40 activation stimulates secretions of insulin and incretin, both of which are the pivotal regulators of glycemic control. Therefore, a GPR40 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19e7fd236db873a26ad100c00b8640fa
https://doi.org/10.1021/acs.jmedchem.0c00843
https://doi.org/10.1021/acs.jmedchem.0c00843
Autor:
Fumie Sakurai, Takafumi Yukawa, Asato Kina, Masataka Murakami, Kazuaki Takami, Sachie Morimoto, Masaki Seto, Makoto Kamata, Tohru Yamashita, Kosuke Nakashima, Naohiro Narita, Ezio Bettini, Annarosa Ugolini, Mauro Corsi, Tomoaki Hasui
Publikováno v:
Bioorganicmedicinal chemistry. 56
N-Methyl-d-aspartate receptors (NMDARs) are members of the ionotropic glutamate receptor family and play a crucial role in learning and memory by regulating synaptic plasticity. Activation of NMDARs containing GluN2A, one of the NMDAR subunits, has r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0577fbe36ce276db8c9af5aad210f2b0
https://pubmed.ncbi.nlm.nih.gov/35051811
https://pubmed.ncbi.nlm.nih.gov/35051811
Autor:
Hideki, Furukawa, Yasufumi, Miyamoto, Yasuhiro, Hirata, Koji, Watanabe, Yuko, Hitomi, Yayoi, Yoshitomi, Jumpei, Aida, Naoyoshi, Noguchi, Nobuyuki, Takakura, Kazuaki, Takami, Seiji, Miwatashi, Yoshihiko, Hirozane, Teruki, Hamada, Ryo, Ito, Mitsugi, Ookawara, Yusuke, Moritoh, Masanori, Watanabe, Tsuyoshi, Maekawa
Publikováno v:
Journal of medicinal chemistry. 63(18)
GPR40/FFAR1 is a G-protein-coupled receptor expressed in pancreatic β-cells and enteroendocrine cells. GPR40 activation stimulates secretions of insulin and incretin, both of which are the pivotal regulators of glycemic control. Therefore, a GPR40 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc19a5909e570e30b7f177db3ae7ad96
https://pubmed.ncbi.nlm.nih.gov/32900194
https://pubmed.ncbi.nlm.nih.gov/32900194
Autor:
Tomoyuki Kitazaki, Kae Matsuda, Hirohisa Miyashita, Shinji Iwasaki, Kenjiro Sato, Shin-ichi Abe, Masahiro Kamaura, Koji Watanabe, Toshiki Murata, Kazuaki Takami, Osamu Kubo, Tomoyuki Odani, Yoshiyuki Tsujihata
Publikováno v:
Bioorganic & Medicinal Chemistry. 41:116208
We undertook an optimization effort involving propan-2-yl 4-({6-[5-(methanesulfonyl)-2,3-dihydro-1H-indol-1-yl]pyrimidin-4-yl}oxy)piperidine-1-carboxylate 1, which we had previously discovered as a novel G protein-coupled receptor 119 (GPR119) agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06da7da98d8f5f5b1b8d577e5040d395
https://doi.org/10.1016/j.bmc.2021.116208
https://doi.org/10.1016/j.bmc.2021.116208
Autor:
Mitsuhisa Yamano, Ryo Mizojiri, Tatsuya Ito, Kazuaki Takami, Maeda Hiroyuki, Tetsuji Kawamoto
Publikováno v:
Organic Process Research & Development. 21:1034-1041
Efficient and stereoselective syntheses of isomerically pure 4-aminotetrahydro-2H-thiopyran 1-oxide derivatives have successfully been achieved. Isomerically pure (4-nitrophenyl)sulfonyltetrahydro-2H-thiopyran 1-oxides were identified by X-ray crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a98f0ff1897f55c623f97d48ff0d0f21
https://doi.org/10.1021/acs.oprd.7b00147
https://doi.org/10.1021/acs.oprd.7b00147
Autor:
Douglas R. Cary, Ryosuke Arai, Daisuke Morishita, Junpei Takeda, Shinobu Sasaki, Ryo Mizojiri, Sachio Shibata, Koichiro Fukuda, Misa Iwatani-Yoshihara, Mai Kosaka, Yohei Kosugi, Yoshihiko Satoh, Daisuke Nakata, Masahiro Kamaura, Kazuaki Takami, Yasuhiro Imaeda, Shigekazu Sasaki
Starting from our previous eIF4A3-selective inhibitor 1a, a novel series of (piperazine-1-carbonyl)pyridin-2(1H)-one derivatives was designed, synthesized, and evaluated for identification of orally bioavailable probe molecules. Compounds 1o and 1q s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648ce1d3f94549d028a6b107ac3f5ffa
https://europepmc.org/articles/PMC5642020/
https://europepmc.org/articles/PMC5642020/
Autor:
Mai Kosaka, Misa Iwatani-Yoshihara, Daisuke Morishita, Masahiro Kamaura, Shinobu Sasaki, Shigekazu Sasaki, Douglas R. Cary, Sachio Shibata, Ryo Mizojiri, Koichiro Fukuda, Yoshihiko Satoh, Ryosuke Arai, Yohei Kosugi, Kazuaki Takami, Daisuke Nakata, Yasuhiro Imaeda, Junpei Takeda
Publikováno v:
Cancer Research. 78:2793-2793
Eukaryotic initiation factor 4A3 (eIF4A3) is a member of the ATP-dependent RNA helicase protein family and controls RNA metabolism, including nonsense-mediated mRNA decay (NMD) and RNA localization, as a core component of the exon junction complex (E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c912d7785e17cee74eb60531bb0167b3
https://doi.org/10.1158/1538-7445.am2018-2793
https://doi.org/10.1158/1538-7445.am2018-2793
Publikováno v:
IEEE Transactions on Audio, Speech and Language Processing. 14:142-151
In order to study the relationship between emotion and intonation, a new technique is introduced for the extraction of the dominant pitches within speech utterances and the quasi-musical analysis of the multipitch structure. After the distribution of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05adba0bcc8cf10efc0d3b8542116744
https://doi.org/10.1109/tsa.2005.854115
https://doi.org/10.1109/tsa.2005.854115
Publikováno v:
Organic Letters. 6:4555-4558
Alkenylation reaction of alpha-halo carbonyl compounds with alkenylindiums proceeded via a radical process in the presence of triethylborane. Unactivated alkene moieties as well as a styryl group could be introduced by this method. The geometry of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e708cb4cf987bbb24f5fdcb257d87a3
https://doi.org/10.1021/ol048070o
https://doi.org/10.1021/ol048070o