Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Kazu Kobayakawa"'
Autor:
Shinkichi Arisumi, Toshifumi Fujiwara, Keitaro Yasumoto, Tomoko Tsutsui, Hirokazu Saiwai, Kazu Kobayakawa, Seiji Okada, Haibo Zhao, Yasuharu Nakashima
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract In osteoclastogenesis, the metabolism of metal ions plays an essential role in controlling reactive oxygen species (ROS) production, mitochondrial biogenesis, and survival, and differentiation. However, the mechanism regulating metal ions du
Externí odkaz:
https://doaj.org/article/b45d89136f8041a1b4eaf028ce97cec6
Autor:
Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Tetsuya Tamaru, Hirotaka Iura, Yohei Haruta, Kazuki Kitade, Keiichiro Iida, Kenichi Kawaguchi, Yoshihiro Matsumoto, Makoto Tsuda, Tomohiko Tamura, Keiko Ozato, Kazuhide Inoue, Dai-Jiro Konno, Takeshi Maeda, Seiji Okada, Yasuharu Nakashima
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract After spinal cord injury (SCI), inflammatory cells such as macrophages infiltrate the injured area, and astrocytes migrate, forming a glial scar around macrophages. The glial scar inhibits axonal regeneration, resulting in significant perman
Externí odkaz:
https://doaj.org/article/c01c6ce110314359af9cbddb6abc6d0f
Autor:
Ryouhei Takeuchi, Kiyoshi Tarukado, Yoshihiro Matsumoto, Kei-ichiro Iida, Kazu Kobayakawa, Hirokazu Saiwai, Kenichi Kawaguchi, Yasuharu Nakashima
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e25180- (2024)
Background: Spinal metastases can impair mobility, worsening the Karnofsky Performance Status (KPS). Surgery for spinal metastases has the potential to improve KPS and extend prognosis, but it is crucial to recognize the elevated risk of perioperativ
Externí odkaz:
https://doaj.org/article/b3c4be1fe62a428682785d454dbd0517
Autor:
Ken Kijima, Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Masamitsu Hara, Shingo Yoshizaki, Kazuya Yokota, Takeyuki Saito, Tetsuya Tamaru, Hirotaka Iura, Yohei Haruta, Kazuki Kitade, Takeshi Utsunomiya, Daijiro Konno, V. Reggie Edgerton, Charles Y. Liu, Hiroaki Sakai, Takeshi Maeda, Kenichi Kawaguchi, Yoshihiro Matsumoto, Seiji Okada, Yasuharu Nakashima
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundSpinal cord injury (SCI) is a devastating disease that results in permanent paralysis. Currently, there is no effective treatment for SCI, and it is important to identify factors that can provide therapeutic intervention during the course o
Externí odkaz:
https://doaj.org/article/93130b1d52e241d2a619f2cdb0523589
Autor:
Yohei Haruta, Kazu Kobayakawa, Hirokazu Saiwai, Kazuhiro Hata, Tetsuya Tamaru, Hirotaka Iura, Gentaro Ono, Kazuki Kitade, Ken Kijima, Keiichiro Iida, Kenichi Kawaguchi, Yoshihiro Matsumoto, Kensuke Kubota, Takeshi Maeda, Dai-Jiro Konno, Seiji Okada, Yasuharu Nakashima
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract In crush syndrome, massive muscle breakdown resulting from ischemia–reperfusion muscle injury can be a life-threatening condition that requires urgent treatment. Blood reperfusion into the ischemic muscle triggers an immediate inflammatory
Externí odkaz:
https://doaj.org/article/4472d094818948ab87e62401bdb29cbc
Autor:
Ken Kijima, Kensuke Kubota, Masamitsu Hara, Kazu Kobayakawa, Kazuya Yokota, Takeyuki Saito, Shingo Yoshizaki, Takeshi Maeda, Daijiro Konno, Yoshihiro Matsumoto, Yasuharu Nakashima, Seiji Okada
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 659-669 (2019)
Background: Spinal cord injury (SCI) is a devastating disorder for which the accurate prediction of the functional prognosis is urgently needed. Due to the lack of reliable prediction methods, the acute evaluation of SCI severity and therapeutic inte
Externí odkaz:
https://doaj.org/article/c82fe87caef3465380847ea80e32e5c6
Autor:
Kazuya Yokota, Kensuke Kubota, Kazu Kobayakawa, Takeyuki Saito, Masamitsu Hara, Ken Kijima, Takeshi Maeda, Hiroyuki Katoh, Yasuyuki Ohkawa, Yasuharu Nakashima, Seiji Okada
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-15 (2019)
Abstract Traumatic spinal cord injury (SCI) causes serious disruption of neuronal circuits that leads to motor functional deficits. Regeneration of disrupted circuits back to their original target is necessary for the restoration of function after SC
Externí odkaz:
https://doaj.org/article/84d8f22f9d314866a7fb1865617c9492
Autor:
Kazuya Yokota, Kazu Kobayakawa, Kensuke Kubota, Atsushi Miyawaki, Hideyuki Okano, Yasuyuki Ohkawa, Yukihide Iwamoto, Seiji Okada
Publikováno v:
Stem Cell Reports, Vol 5, Iss 2, Pp 264-277 (2015)
Neural stem/progenitor cell (NSPC) transplantation is a promising therapeutic strategy for spinal cord injury (SCI). However, the efficacy of NSPC transplantation on severe SCI is poorly understood. We herein show that NSPC transplantation promotes f
Externí odkaz:
https://doaj.org/article/87b01f6f298c4f1caaded7952e6ceed5
Autor:
Takeyuki Saito, Kazuya Yokota, Kazu Kobayakawa, Masamitsu Hara, Kensuke Kubota, Katsumi Harimaya, Kenichi Kawaguchi, Mitsumasa Hayashida, Yoshihiro Matsumoto, Toshio Doi, Keiichiro Shiba, Yasuharu Nakashima, Seiji Okada
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169717 (2017)
Lumbar spinal canal stenosis (LSCS) is one of the most common spinal disorders in elderly people, with the number of LSCS patients increasing due to the aging of the population. The ligamentum flavum (LF) is a spinal ligament located in the interior
Externí odkaz:
https://doaj.org/article/e9fbec609c744c64892eae46c4ea7b3d
Autor:
Jimbayashi, Hideki, Iida, Keiichiro, Kazu, Kobayakawa, Saiwai, Hirokazu, Kawaguchi, Kenichi, Matsumoto, Yoshihiro, Nakashima, Yasuharu
Publikováno v:
In Journal of Orthopaedics October 2023 44:12-16