Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kazimierz Studzian"'
Autor:
Justyn Ochocki, Maria M. Kasprzak, Joanna Sikora, Małgorzata Fabijańska, Elżbieta Mikiciuk-Olasik, Kazimierz Studzian, Magdalena Markowicz-Piasecka, Lilianna Chęcińska
Publikováno v:
Inorganica Chimica Acta. 457:69-80
Ruthenium compounds are a class of potential anticancer agents in a field with many emerging metal-based drugs and drug candidates. This work presents the synthesis and structural evaluation of a new Ru(II) complex of 3-hydroxyiminoflavanone with spe
Autor:
Krzysztof Kik, Kazimierz Studzian, Malgorzata Strek, Leszek Szmigiero, Irena Oszczapowicz, Malgorzata Lukawska
Publikováno v:
Investigational New Drugs
SummaryIn this study, we compared the cellular uptake, intracellular localization and cytotoxicity of two groups of anthracycline derivatives in cultured H9c2(2-1) rat cardiomyoblasts. The first group consisted of doxorubicin (DOX) and two of its der
Autor:
Wojciech M. Wolf, Jakub Wojciechowski, Lukasz Albrecht, Marek Rozalski, Kazimierz Studzian, Tomasz Janecki, Anna Albrecht, Henryk Krawczyk, Anna Janecka, Urszula Krajewska
Publikováno v:
European Journal of Medicinal Chemistry. 45:710-718
We present a simple and general strategy for the synthesis of β,δ-disubstituted-α-methylene-δ-lactones starting from easily available tert-butyl 2-(diethoxyphosphoryl)alk-2-enoates. The elaborated synthetic protocol includes pyrrolidine-catalyzed
Publikováno v:
European Journal of Medicinal Chemistry. 44:660-664
A series of square-planar platinum(II) and palladium(II) complexes of the formula cis-[PtCl2L2] and trans-[PdCl2L2] [L stands for diethyl (pyridin-2-ylmethyl)phosphate (2-pmOpe) or diethyl (pyridin-3-ylmethyl)phosphate (3-pmOpe) or diethyl (pyridin-4
Autor:
Anna Albrecht, Tomasz Janecki, Jakub Modranka, Urszula Krajewska, Jacek F. Koszuk, Kazimierz Studzian, Marek Rozalski, Anna Janecka
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:4872-4882
A series of 5-aryl-3-alkylidenedihydrofuran-2(3 H )-ones 6a – g ″ and 11a , b as well as 5-aryl-3-methylidenepyrrolidin-2-ones 10a – c and 12 were synthesized starting from 4-aryl-2-diethoxyphosphoryl-4-oxobutanoates 3a – g . Reaction sequenc
Autor:
Kazimierz Studzian, Heleen Verlinden, Anna Janecka, Vanessa Franssens, Jeroen Poels, Ronald J. Nachman, Jakub Fichna, Tom Van Loy, Jozef Vanden Broeck
Publikováno v:
Peptides. 28:103-108
Tachykinins are multifunctional neuropeptides that have been identified in vertebrates as well as invertebrates. The C-terminal FXGXRa-motif constitutes the consensus active core region of invertebrate tachykinins. In Drosophila, two putative G prote
Autor:
Anna Albrecht, Kazimierz Studzian, Edyta Warzycha, Tomasz Janecki, Anna Janecka, Urszula Krajewska, Marek Rozalski
Publikováno v:
Chemistry & Biodiversity. 2:1256-1265
A series of enantiomerically enriched 4,5-dihydro-5-[aryl(hydroxy)methyl]-3-methylidenefuran-2(3H)-ones (8) were synthesized by means of asymmetric Sharpless dihydroxylation of the 2-phosphorylated 5-aryl-pent-4-enoic acids 13, followed by Horner-Wad
Publikováno v:
Cell Biology and Toxicology. 21:139-147
Daunorubicin (DRB) and its two analogues containing a trisubstituted amidino group at the C-3' position of the daunosamine moiety have been compared regarding their cytotoxic activity, cellular uptake, subcellular localization and DNA damaging proper
Autor:
Justyn Ochocki, Małgorzata Fabijańska, Elzbieta Zyner, Piotr Smolewski, Leszek Szmigiero, Kazimierz Studzian, Arno Pfitzner, Agnieszka J. Rybarczyk-Pirek, Barbara Cebula-Obrzut
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 44(3)
This paper describes the synthesis of trans-bis-(3-aminoflavone)dichloridoplatinum(II) (trans-Pt(3-af)2Cl2; TCAP) for use as a potential anticancer compound, and the evaluation of its structure by elemental and spectral analyses, and X-ray crystallog
Publikováno v:
Acta Biochimica Polonica. 45:127-132
9-Aminoacridine carboxamide derivatives studied here form with DNA intercalative complexes which differ in the kinetics of dissociation. Inhibition of total RNA synthesis catalyzed by phage T7 and Escherichia coli DNA-dependent RNA polymerases correl