Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Kazim Husain"'
Autor:
Ehsan Habeeb, Saad Aldosari, Shakil A. Saghir, Mariam Cheema, Tahani Momenah, Kazim Husain, Yadollah Omidi, Syed A.A. Rizvi, Muhammad Akram, Rais A. Ansari
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 521-533 (2022)
The incidence of hypertension with diabetes mellitus (DM) as a co-morbid condition is on the rise worldwide. In 2000, an estimated 972 million adults had hypertension, which is predicted to grow to 1.56 billion by 2025. Hypertension often leads to di
Externí odkaz:
https://doaj.org/article/472e220646e64a35a410f4c23dc4d59e
Publikováno v:
Immunological Medicine, Vol 44, Iss 3, Pp 159-174 (2021)
Protein kinase CK2, formally known as casein kinase II, is ubiquitously expressed and highly conserved serine/threonine or tyrosine kinase enzyme that regulates diverse signaling pathways responsible for cellular processes (i.e., cell proliferation a
Externí odkaz:
https://doaj.org/article/d56efb2c111040db87257138964c3062
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The activation and growth of tumour-initiating cells with stem-like properties in distant organs characterize colorectal cancer (CRC) growth and metastasis. Thus, inhibition of colon cancer stem cell (CCSC) growth holds promise for CRC growt
Externí odkaz:
https://doaj.org/article/48038e2a84504fb88f55ecb9c9524bbc
Autor:
Sridevi Challa, Kazim Husain, Richard Kim, Domenico Coppola, Surinder K. Batra, Jin Q. Cheng, Mokenge P. Malafa
Publikováno v:
Translational Oncology, Vol 13, Iss 2, Pp 481-489 (2020)
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with an overall median 5-year survival rate of 8%. This poor prognosis is because of the development of resistance to chemotherapy and radiation therapy and lack of effective targeted therap
Externí odkaz:
https://doaj.org/article/31ba8cdbcfc644d08689f7e10dddd7ab
Autor:
Nishat Fatima, Syed Shabihe Raza Baqri, Atrayee Bhattacharya, Nii Koney-Kwaku Koney, Kazim Husain, Ata Abbas, Rais A. Ansari
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Epigenetic regulation involves reversible changes in histones and DNA modifications that can be inherited without any changes in the DNA sequence. Dysregulation of normal epigenetic processes can lead to aberrant gene expression as observed in many d
Externí odkaz:
https://doaj.org/article/9c49d876f7f842eea1ba5c5a9062dc93
Autor:
Rony A. Francois, Anying Zhang, Kazim Husain, Chen Wang, Sean Hutchinson, Michael Kongnyuy, Surinder K. Batra, Domenico Coppola, Said M. Sebti, Mokenge P. Malafa
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background Vitamin E δ-tocotrienol (VEDT), a vitamin E compound isolated from sources such as palm fruit and annatto beans, has been reported to have cancer chemopreventive and therapeutic effects. Methods We report a novel function of VEDT
Externí odkaz:
https://doaj.org/article/4b1eb33314e540faa53a9f54910cd308
Autor:
Gregory M. Springett, Kazim Husain, Anthony Neuger, Barbara Centeno, Dung-Tsa Chen, Tai Z. Hutchinson, Richard M. Lush, Saïd Sebti, Mokenge P. Malafa
Publikováno v:
EBioMedicine, Vol 2, Iss 12, Pp 1987-1995 (2015)
Background: Vitamin E δ-tocotrienol (VEDT), a natural vitamin E from plants, has shown anti-neoplastic and chemoprevention activity in preclinical models of pancreatic cancer. Here, we investigated VEDT in patients with pancreatic ductal neoplasia i
Externí odkaz:
https://doaj.org/article/3e5c7dfe7bed4760b696ac8e689e2e9a
Autor:
Nadine Nelson, Shengyan Xiang, Xiaohong Zhang, Danielle Gilvary, Julie Djeu, Kazim Husain, Mokenge Malafa, Nasreen Vohra, Shari Pilon-Thomas, Tomar Ghansah
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0115546 (2015)
Maintenance of T cell immune homeostasis is critical for adequate anti-tumor immunity. The transcription factor Ikaros is essential for lymphocyte development including T cells. Alterations in Ikaros expression occur in blood malignancies in humans a
Externí odkaz:
https://doaj.org/article/3705ff51242c4a068cfaac25c8a17a01
Autor:
Jennifer Permuth-Wey, Y Ann Chen, Kate Fisher, Susan McCarthy, Xiaotao Qu, Mark C Lloyd, Agnieszka Kasprzak, Michelle Fournier, Vonetta L Williams, Kavita M Ghia, Sean J Yoder, Laura Hall, Christina Georgeades, Funmilayo Olaoye, Kazim Husain, Gregory M Springett, Dung-Tsa Chen, Timothy Yeatman, Barbara Ann Centeno, Jason Klapman, Domenico Coppola, Mokenge Malafa
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116869 (2015)
BACKGROUND:Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic ductal adenocarcinoma (PDAC) precursors. Differentiating between high-risk IPMNs that warrant surgical resection and low-risk IPMNs that can be monitored is a significant clin
Externí odkaz:
https://doaj.org/article/f9b5e8d0fb8b46b4957c592ee9a83ced
Autor:
Dung-Tsa Chen, Ashley H Davis-Yadley, Po-Yu Huang, Kazim Husain, Barbara A Centeno, Jennifer Permuth-Wey, Jose M Pimiento, Mokenge Malafa
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0133562 (2015)
The outcomes of patients treated with surgery for early stage pancreatic ductal adenocarcinoma (PDAC) are variable with median survival ranging from 6 months to more than 5 years. This challenge underscores an unmet need for developing personalized m
Externí odkaz:
https://doaj.org/article/66e7ccd8792c4e7e93e0a9932f046f40