Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kazem Ahmed Mahmoud"'
Publikováno v:
Journal of Heterocyclic Chemistry. 54:714-719
The reaction of indoles with dialdehydes was studied for the first time. Mild reaction conditions using glacial acetic acid led to two novel kinds of reaction products: one designated as alkyl chain-connected tetraindoles and the other one as bis(ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2eb1954014b9616c46f8550eafe62e1
https://doi.org/10.1002/jhet.2542
https://doi.org/10.1002/jhet.2542
Publikováno v:
European Journal of Medicinal Chemistry. 90:845-859
BIMs (bis-indolylmethanes) ( 1 a–n ) were synthesized using glacial acetic acid as a protic acid for promotion of the condensation reaction of indoles with aldehydes in high yields (86–98 %). Corresponding tetrahydroindolo[2,3- b ]carbazoles ( 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd275c653d0632f7fcdeff54da94198a
https://doi.org/10.1016/j.ejmech.2014.12.008
https://doi.org/10.1016/j.ejmech.2014.12.008
Publikováno v:
Current Organic Chemistry. 17:1200-1224
Chemistry and pharmacological activity of various types of Mannich bases and their derivatives were well documented. A sur- vey of the literature revealed extensive studies on the synthesis and reactivity of Mannich bases derived from ketones, amides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa71f7a06476334dc816b4051074c608
https://doi.org/10.2174/1385272811317110007
https://doi.org/10.2174/1385272811317110007
Publikováno v:
Current Chemistry Letters, Vol 3, Iss 1, Pp 7-14 (2014)
Glacial acetic acid as a protic acid was employed as a catalyst in a solvent free condition for facile preparation of di(indolyl)methanes (DIMs) via one-pot condensation of indole with aryl or heteroaryl aldehydes. Various aryl and heteroaryl aldehyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bac84ac095d5bdf05717907d157646d
https://doi.org/10.5267/j.ccl.2013.10.003
https://doi.org/10.5267/j.ccl.2013.10.003
Autor:
Lydia Herrmann, Kazem Ahmed Mahmoud, Max Holzer, Christoph Schächtele, Frank Totzke, Andreas Hilgeroth, Volkmar Tell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6914-6918
Alzheimer disease (AD) turned out to be a multifactorial process leading to neuronal decay. So far merely single target structures which attribute to the AD progression have been considered to develop specific drugs. However, such drug developments h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbb71bd8e60b256e9a5fe63229e54ec
https://doi.org/10.1016/j.bmcl.2012.09.006
https://doi.org/10.1016/j.bmcl.2012.09.006
Autor:
Wolfgang Sippl, Tom Wersig, Kazem Ahmed Mahmoud, Andreas Hilgeroth, Christoph A. Ritter, Markus Oelze
Publikováno v:
International journal of clinical pharmacology and therapeutics. 53(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0ab980c32b6c99a3415e8007b50414
https://pubmed.ncbi.nlm.nih.gov/26396134
https://pubmed.ncbi.nlm.nih.gov/26396134
Publikováno v:
ChemInform. 44
Chemistry and pharmacological activity of various types of Mannich bases and their derivatives were well documented. A sur- vey of the literature revealed extensive studies on the synthesis and reactivity of Mannich bases derived from ketones, amides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc53abae6cacf17d4adc749197db892b
https://doi.org/10.1002/chin.201351259
https://doi.org/10.1002/chin.201351259
Autor:
Max Holzer, Frank Totzke, Lydia Herrmann, Kazem Ahmed Mahmoud, Christoph Schaechtele, Andreas Hilgeroth, Volkmar Tell
Publikováno v:
ChemInform. 44
Two new nanomolar active CDK1, CDK5/p25 and GSK-3β inhibitors of the 3,6-dihydroxy-1-aza-9-oxafluorene type (IV) are discovered.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1858c3606645b16f5688a448db1a809a
https://doi.org/10.1002/chin.201314182
https://doi.org/10.1002/chin.201314182
Autor:
Andreas Hilgeroth, Tom Wersig, Wolfgang Sippl, Inna Slynko, Christoph Schächtele, Frank Totzke, Markus Oelze, Christoph A. Ritter, Kazem Ahmed Mahmoud
Publikováno v:
MedChemComm. 5:659
Novel 4-anilino pyrido[2,3-b]indoles have been discovered as inhibitors of the breast cancer relevant protein kinase Brk. Within this first series favourable aniline substituents have been characterized. Combinations with substituents of the molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a4142a3db95d8fc7bb5e90b2633e097
https://doi.org/10.1039/c4md00028e
https://doi.org/10.1039/c4md00028e
Autor:
Kanin Wichapong, Volkmar Tell, Andreas Hilgeroth, Frank Totzke, Christoph Schächtele, Kazem Ahmed Mahmoud, Wolfgang Sippl
Publikováno v:
MedChemComm. 3:1413
A novel series of derivatized 1-aza-9-oxafluorenes has been synthesized. Structure-directed substituents have been introduced and their effect on the inhibition of Alzheimer's disease-relevant kinases has been determined in in vitro assays. Novel str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bf6371a6df98eae88a8a38a59c74ab3
https://doi.org/10.1039/c2md20201h
https://doi.org/10.1039/c2md20201h