Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Kayvon Pedram"'
Publikováno v:
mSphere, Vol 9, Iss 9 (2024)
ABSTRACT Expansion microscopy (ExM) is an innovative approach to achieve super-resolution images without using super-resolution microscopes, based on the physical expansion of the sample. The advent of ExM has unlocked the detail of super-resolution
Externí odkaz:
https://doaj.org/article/e6eb544e7ffe465f923706e5a6aace94
Autor:
Stacy A. Malaker, Nicholas M. Riley, D. Judy Shon, Kayvon Pedram, Venkatesh Krishnan, Oliver Dorigo, Carolyn R. Bertozzi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Mucin-domain glycoproteins are densely O-glycosylated proteins with unique secondary structure that imparts a large influence on cellular environments. Here, the authors develop a technique to selectively enrich and characterize mucin-domain glycopro
Externí odkaz:
https://doaj.org/article/011718bd9681426e8bb6f573bfbb80d9
Autor:
Chih-Hao Lu, Kayvon Pedram, Ching-Ting Tsai, Taylor Jones, Xiao Li, Melissa L. Nakamoto, Carolyn R. Bertozzi, Bianxiao Cui
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
MUC1 is a heavily glycosylated protein on the cell surface. Here the authors show that MUC1 prefers negative over positive membrane curvature due to its bulky size, enabling MUC1 to avoid endocytosis and surface removal based on curvature preference.
Externí odkaz:
https://doaj.org/article/62c537b493c04850a128441c4ecadfc7
Autor:
Karim Almahayni, Malte Spiekermann, Antonio Fiore, Guoqiang Yu, Kayvon Pedram, Leonhard Möckl
Publikováno v:
Matrix Biology Plus, Vol 16, Iss , Pp 100126- (2022)
Externí odkaz:
https://doaj.org/article/ba0267c1ca7b434385d7811124cb8ffc
Autor:
Karim Almahayni, Malte Spiekermann, Antonio Fiore, Guoqiang Yu, Kayvon Pedram, Leonhard Möckl
Publikováno v:
Matrix Biology Plus, Vol 16, Iss , Pp 100108- (2022)
Glycans are one of the fundamental biopolymers encountered in living systems. Compared to polynucleotide and polypeptide biosynthesis, polysaccharide biosynthesis is a uniquely combinatorial process to which interdependent enzymes with seemingly broa
Externí odkaz:
https://doaj.org/article/a538bc9d9f1d408ea01d3a10f9d5b593
Autor:
Elliot C Woods, FuiBoon Kai, J Matthew Barnes, Kayvon Pedram, Michael W Pickup, Michael J Hollander, Valerie M Weaver, Carolyn R Bertozzi
Publikováno v:
eLife, Vol 6 (2017)
Metastasis depends upon cancer cell growth and survival within the metastatic niche. Tumors which remodel their glycocalyces, by overexpressing bulky glycoproteins like mucins, exhibit a higher predisposition to metastasize, but the role of mucins in
Externí odkaz:
https://doaj.org/article/57d15b33b0224ade94a986318753f5e6
Autor:
Kayvon Pedram, Nouf N. Laqtom, D. Judy Shon, Alessandro Di Spiezio, Nicholas M. Riley, Paul Saftig, Monther Abu-Remaileh, Carolyn R. Bertozzi
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Mucins are functionally implicated in a range of human pathologies, including cystic fibrosis, influenza, bacterial endocarditis, gut dysbiosis, and cancer. These observations have motivated the study of mucin biosynthesis as well as the development
Autor:
Kayvon Pedram, D. Judy Shon, Gabrielle S. Tender, Natalia R. Mantuano, Jason J. Northey, Kevin J. Metcalf, Simon P. Wisnovsky, Nicholas M. Riley, Giovanni C. Forcina, Stacy A. Malaker, Angel Kuo, Benson M. George, Caitlyn L. Miller, Kerriann M. Casey, José G. Vilches-Moure, Valerie M. Weaver, Heinz Laübli, Carolyn R. Bertozzi
Targeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Here, to expand the landscape of substrates that can be selectively degraded, we designed degraders which are dependent on both peptide sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eae7cde10003a5bd8961704a25b061e
https://doi.org/10.1101/2022.05.20.492748
https://doi.org/10.1101/2022.05.20.492748
Autor:
Green Ahn, Simon Wisnovsky, Kayvon Pedram, Nicholas M. Riley, Steven M. Banik, Carolyn R. Bertozzi
Publikováno v:
Nature. 584:291-297
The majority of therapies that target individual proteins rely on specific activity-modulating interactions with the target protein—for example, enzyme inhibition or ligand blocking. However, several major classes of therapeutically relevant protei
Autor:
Alex G. Johnson, Jan E. Carette, Ryan A. Flynn, Karim Majzoub, Benjamin A. H. Smith, Stacy A. Malaker, Pedro J. Batista, Benson M. George, Kayvon Pedram, Peter W. Villalta, Carolyn R. Bertozzi
Publikováno v:
Cell
Glycans modify lipids and proteins to mediate inter- and intramolecular interactions across all domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge this view with evidence that mammals use RNA as a third scaf