Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kayvon Jalali"'
Autor:
Sam R. J. Hoare, Graham Beaton, Bin-Feng Li, Paul D. Crowe, Said Zamani-Kord, Lisa M. Hernández, Wilna J. Moree, Charles Q. Huang, Jinghua Yu, Hua Wang, Siobhan Malany, Fabio C. Tucci, Chun Yang, Ajay Madan, Aida Sacaan, Robert E. Petroski, Jianyun Wen, Coon Timothy Richard, Margaret J. Bradbury, Kayvon Jalali, Dragan Marinkovic
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(19)
Analogs of the known H(1)-antihistamine R-dimethindene with suitable selectivity for key GPCRs, P450 enzymes and hERG channel were assessed for metabolism profile and in vivo properties. Several analogs were determined to exhibit diverse metabolism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27771b1fadd5556d09bba470020874b2
https://pubmed.ncbi.nlm.nih.gov/20800486
https://pubmed.ncbi.nlm.nih.gov/20800486
Autor:
Paul D. Crowe, Chun Yang, Robert E. Petroski, Kayvon Jalali, Coon Timothy Richard, Wilna J. Moree, Sam R. J. Hoare, Bin-Feng Li, Said Zamani-Kord, Hua Wang, Graham Beaton, Siobhan Malany, Jianyun Wen, Ajay Madan, Jinghua Yu
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(8)
A series of indene analogs of the H1-antihistamine (−)-R-dimethindene was evaluated for selectivity in the search for potentially improved sedative-hypnotics. Variation of the 6-substitutent in the indene core in combination with a pendant electron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be894ba9de790b30f323cfdd66230c69
https://pubmed.ncbi.nlm.nih.gov/20227880
https://pubmed.ncbi.nlm.nih.gov/20227880
Autor:
Raymond S. Gross, John P. Williams, Tanya Joswig, Emily Lin, Stacy Markison, Deborah H. Slee, Marion Lanier, William Kargo, Jaime Piercey, Jose-Luis Diaz, Zhiyong Luo, John E. Tellew, Zhihong O’Brien, Marilyn Zhao, Siobhan Malany, Kayvon Jalali, Mark Santos, Sandra M. Lechner, Ajay Madan, Xiaohu Zhang, Jenny Wen, Yongsheng Chen, Manisha Moorjani, Robert E. Petroski, María I. Crespo, John Saunders
Publikováno v:
Journal of medicinal chemistry. 52(3)
In the present article, we report on a strategy to improve the physical properties of a series of small molecule human adenosine 2A (hA2A) antagonists. One of the aromatic rings typical of this series of antagonists is replaced with a series of aliph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae503fc7029e4651564ca3936c005ae
https://pubmed.ncbi.nlm.nih.gov/19140664
https://pubmed.ncbi.nlm.nih.gov/19140664
Autor:
Stacy Markison, Sandra M. Lechner, John Saunders, John P. Williams, Silvia Gual, Siobhan Malany, Jaimie K. Rueter, Maria Prat, Raymond S. Gross, Julio C. Castro-Palomino, Tanya Joswig, Kayvon Jalali, Zhiyang Zuo, Manisha Moorjani, Deborah H. Slee, Jose-Luis Diaz, Robert E. Petroski, María I. Crespo, Chun Yang, Yang Sai, Emily Lin, Zhihong O’Brien, Marion Lanier, Xiaohu Zhang, Jenny Wen, Mark Santos, Yongsheng Chen
Publikováno v:
Journal of medicinal chemistry. 51(6)
Previously we have described a series of novel A 2A receptor antagonists with excellent water solubility. As described in the accompanying paper, the antagonists were first optimized to remove an unsubstituted furyl moiety, with the aim of avoiding t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226a608572d86ea3081c27e5732dbbd6
https://pubmed.ncbi.nlm.nih.gov/18307293
https://pubmed.ncbi.nlm.nih.gov/18307293
Autor:
Silvia Gual, Chun Yang, Yang Sai, Kayvon Jalali, Sandra M. Lechner, Marion Lanier, Mark Santos, Yongsheng Chen, Maria Prat, Julio C. Castro-Palomino, John Saunders, Stacy Markison, John P. Williams, Emily Lin, Jaimie K. Rueter, Jose-Luis Diaz, María I. Crespo, Zhiyang Zuo, Manisha Moorjani, Deborah H. Slee, Raymond S. Gross, Xiaohu Zhang, Siobhan Malany
Publikováno v:
Journal of medicinal chemistry. 51(6)
Previously we have described a novel series of potent and selective A2A receptor antagonists (e.g., 1) with excellent aqueous solubility.(1) While these compounds are efficacious A2A antagonists in vivo, the presence of an unsubstituted furyl moiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635873e0540ea30701b581ce36af9624
https://pubmed.ncbi.nlm.nih.gov/18307292
https://pubmed.ncbi.nlm.nih.gov/18307292
Autor:
Xiaohu Zhang, John E. Tellew, Zhiyong Luo, Manisha Moorjani, Emily Lin, Marion C. Lanier, Yongsheng Chen, John P. Williams, John Saunders, Sandra M. Lechner, Stacy Markison, Tanya Joswig, Robert Petroski, Jaime Piercey, William Kargo, Siobhan Malany, Mark Santos, Raymond S. Gross, Jenny Wen, Kayvon Jalali
Publikováno v:
Journal of Medicinal Chemistry; Nov2008, Vol. 51 Issue 22, p7099-7110, 12p
Autor:
Deborah H. Slee, Manisha Moorjani, Xiaohu Zhang, Emily Lin, Marion C. Lanier, Yongsheng Chen, Jaimie K. Rueter, Sandra M. Lechner, Stacy Markison, Siobhan Malany, Tanya Joswig, Mark Santos, Raymond S. Gross, John P. Williams, Julio C. Castro-Palomino, María I. Crespo, Maria Prat, Silvia Gual, José-Luis Díaz, Kayvon Jalali
Publikováno v:
Journal of Medicinal Chemistry; Feb2008, Vol. 51 Issue 6, p1730-1739, 10p
Autor:
Deborah H. Slee, Yongsheng Chen, Xiaohu Zhang, Manisha Moorjani, Marion C. Lanier, Emily Lin, Jaimie K. Rueter, John P. Williams, Sandra M. Lechner, Stacy Markison, Siobhan Malany, Mark Santos, Raymond S. Gross, Kayvon Jalali, Yang Sai, Zhiyang Zuo, Chun Yang, Julio C. Castro-Palomino, María I. Crespo, Maria Prat
Publikováno v:
Journal of Medicinal Chemistry; Feb2008, Vol. 51 Issue 6, p1719-1729, 11p