Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Kayoko Ohura"'
Publikováno v:
Archives of Pharmacy Practice, Vol 3, Iss 1, Pp 36-36 (2012)
Externí odkaz:
https://doaj.org/article/734f3394a4074ec78437319304460e8c
Autor:
Kayoko Ohura, Teruko Imai
Publikováno v:
Archives of Pharmacy Practice, Vol 3, Iss 1, Pp 102-102 (2012)
Externí odkaz:
https://doaj.org/article/45f44f9626484b5893460cadfd79229d
Publikováno v:
Archives of Pharmacy Practice, Vol 3, Iss 1, Pp 97-97 (2012)
Externí odkaz:
https://doaj.org/article/c35f3e287c8147788dce199e09655f67
Publikováno v:
Journal of Pharmaceutical Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d39d7272c97c41847404392d4094d65
https://doi.org/10.1016/j.xphs.2023.03.018
https://doi.org/10.1016/j.xphs.2023.03.018
Autor:
Kayoko Ohura
Publikováno v:
YAKUGAKU ZASSHI. 140:369-376
The first-pass hydrolysis of oral ester-type prodrugs in the liver and intestine is mediated mainly by hCE1 and hCE2 of the respective predominant carboxylesterase (CES) isozymes. In order to provide high blood concentrations of the parent drugs, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c920d96c8361e5e1c85e857ec2924fa
https://doi.org/10.1248/yakushi.19-00225
https://doi.org/10.1248/yakushi.19-00225
Publikováno v:
Journal of Pharmaceutical Sciences. 108:2791-2797
The glycopyrrolate soft analog, SGM, designed to be easily hydrolyzed into the significantly less active zwitterionic metabolite, SGa, typifies soft drug that reduces systemic side effects (a problem often seen with traditional anticholinergics) foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7605f40316d67abe8b9d3aa7d6b25f
https://doi.org/10.1016/j.xphs.2019.03.030
https://doi.org/10.1016/j.xphs.2019.03.030
Autor:
Kayoko Ohura, Hassan M.D. Mahadhi, Teruko Imai, Masakiyo Hosokawa, Shotaro Uehara, Yasuhiro Uno
Publikováno v:
Journal of Medical Primatology. 47:185-191
Background Butyrylcholinesterase (BChE), an enzyme essential for drug metabolism, has been investigated as antidotes against organophosphorus nerve agents, and the efficacy and safety have been studied in cynomolgus macaques. BChE polymorphisms partl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d4fb0151df1c86131315c3d489ea88
https://doi.org/10.1111/jmp.12342
https://doi.org/10.1111/jmp.12342
Autor:
Yoshiteru Watanabe, Rieko Ohara, Azusa Matsumi, Teruko Imai, Naoya Koizumi, Kayoko Ohura, Makiko Fujii
Publikováno v:
European Journal of Pharmaceutical Sciences. 109:280-287
We studied the effect that three alcohols, ethanol (EA), propanol (PA), and isopropanol (IPA), have on the skin permeation of p-hydroxy benzoic acid methyl ester (HBM), a model ester-type prodrug. HBM was applied to Yucatan micropig skin in a saturat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab58f200d8fb878cd0a2ea66bdd2933
https://doi.org/10.1016/j.ejps.2017.08.012
https://doi.org/10.1016/j.ejps.2017.08.012
Autor:
Naoya Wada, Kazuishi Kubota, Yoshiyuki Igawa, Kayoko Ohura, Kana Matsumoto, Yasuhiro Uno, Teruko Imai, Maori Tanaka, Akiko Kasahara
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(3)
In contrast to a single human carboxylesterase 2 (CES2) isozyme (hCE2), three CES2 genes have been identified in cynomolgus monkeys: mfCES2A, mfCES2B, and mfCES2C. Although mfCES2A protein is expressed in several organs, mfCES2B is a pseudogene and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da52f48f21e1bc8f62c7e7d39d6bd5a
https://pubmed.ncbi.nlm.nih.gov/31836607
https://pubmed.ncbi.nlm.nih.gov/31836607
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 139(5)
The hydrolysis activity and expression level of carboxylesterase (CES) in skin were compared with liver and intestine in the same individual of beagle dog and cynomolgus monkey, and their aging effects were studied. CES1 isozymes were mainly present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6f842de51bd53478185a1e11701109
https://pubmed.ncbi.nlm.nih.gov/31061351
https://pubmed.ncbi.nlm.nih.gov/31061351