Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kayoko Niinuma"'
Autor:
Shin-ichi Kanamitsu, Jun Aoki, Motohiro Kato, Yuko Tsukamoto, Yasumasa Gotoh, Kaoru Ueda, Takafumi Iwatsubo, Masato Horikawa, Michi Ishigami, Kiyomi Ito, Norihito Sato, Tomoo Itoh, Kayoko Niinuma, Yuichi Sugiyama, Akiko Nishino, Naomi Mizuno, Koji Chiba, Iichiro Kawahara
Publikováno v:
AAPS PharmSci. 4:53-60
When the metabolism of a drug is competitively or noncompetitively inhibited by another drug, the degree of in vivo interaction can be evaluated from the [I]u/Ki ratio, where [I]u is the unbound concentration around the enzyme and Ki is the inhibitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df781e7d2272a32482e49ae4cad6fc27
https://doi.org/10.1208/ps040425
https://doi.org/10.1208/ps040425
Autor:
Akihiro Hisaka, Kayoko Niinuma, Tetsuya Terasaki, Yukio Kato, Masayo Yamazaki, Tadashi Yamada, Yuichi Sugiyama, Hiroshi Suzuki, Ho-Chul Shin
Publikováno v:
Drug Metabolism and Pharmacokinetics. 10:112-115
Recently, for many endogenous and exogenous compounds(including drugs), it has been reported that carrier-mediated primary active transport contributes to biliary excretion. Compounds known to be excreted by this mechanism are anticancer drugs, endog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa95735a141355ae1d0ebada1b0d904f
https://doi.org/10.2133/dmpk.10.supplement_112
https://doi.org/10.2133/dmpk.10.supplement_112
Autor:
Hiroshi Suzuki, Carol E. Green, Yukio Kato, Ritchie Froehlich, Yuichi Sugiyama, Jack E. Dabbs, Charles A. Tyson, Kayoko Niinuma, Valorie Weizer
Publikováno v:
The American journal of physiology. 276(5)
Biliary excretion of several anionic compounds was examined by assessing their ATP-dependent uptake in bile canalicular membrane vesicles (CMV) prepared from six human liver samples. 2,4-Dinitrophenyl- S-glutathione (DNP-SG), leukotriene C4(LTC4), su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da413be88690752835457da958e7a60
https://pubmed.ncbi.nlm.nih.gov/10330006
https://pubmed.ncbi.nlm.nih.gov/10330006
Publikováno v:
Scopus-Elsevier
The hepatobiliary transport of an anionic cyclopentapeptide endothelin antagonist, BQ-123, was studied in rats. Biliary excretion of [3H]BQ-123 was extensive in vivo (approximately 75% of intravenous infusion rates). Liver-to-plasma and bile-to-liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db9c4c493363d1bbd49efad91ef4eb6
https://pubmed.ncbi.nlm.nih.gov/9176204
https://pubmed.ncbi.nlm.nih.gov/9176204
Autor:
Takao Shimizu, Kousei Ito, Yuichi Sugiyama, Hiroshi Suzuki, Tomoko Hirohashi, Kayoko Niinuma, Kazuhiko Kume
Publikováno v:
Drug Metabolism and Pharmacokinetics. 11:5098-5099
Several organic anions, including the glutathione- and glucuronide-conjugates, are excreted into the bile via a canalicular multispecific organic anion transporter (cMOAT), which is hereditarily defective in mutant rats such as Eisai hyperbilirubinem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d71badddecd1b98887ec9efd4362723
https://doi.org/10.2133/dmpk.11.supplement_5098
https://doi.org/10.2133/dmpk.11.supplement_5098