Výsledky vyhledávání - "Kayoko Nakayama"

Tumor Microenvironment-Sensitive Liposomes Penetrate Tumor Tissue via Attenuated Interaction of the Extracellular Matrix and Tumor Cells and Accompanying Actin Depolymerization

Autor: Susumu Hama, Kentaro Kogure, Takayuki Nishi, Shoko Itakura, Kayoko Nakayama, Satoko Suzuki, Akinori Nishimoto, Ryo Matsui

Publikováno v: Biomacromolecules. 18(2)

Delivery of anticancer drugs into tumor cores comprised of malignant cancer cells can result in potent therapeutic effects. However, conventional nanoparticle-based drug delivery systems used for cancer therapy often exhibit inefficient tumor-penetra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8268543d4409197987d96defcae5cf
https://pubmed.ncbi.nlm.nih.gov/28055201

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Development of a novel drug delivery system consisting of an antitumor agent tocopheryl succinate

Autor: Kenji Fukuzawa, Kayoko Nakayama, Yuki Fukuda, Satoru Utsumi, Hiroyuki Tsuchiya, Kentaro Kogure, Yuriko Okamura, Hedeyoshi Harashima, Susumu Hama

Publikováno v: Journal of Controlled Release. 161:843-851

We have developed a novel drug delivery system (DDS) using an antitumor agent, α-tocopheryl succinate (TS). TS has attracted attention as a unique anti-cancer drug for its ability to induce apoptosis in various cancer cells. Furthermore, TS itself r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74518f161d8bad18d78678e3bb0748f5
https://doi.org/10.1016/j.jconrel.2012.05.031

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Effects of Co-Administration of Tea Epigallocatechin-3-gallate (EGCG) and Caffeine on Absorption and Metabolism of EGCG in Humans

Autor: Teruo Miyazawa, Fumiko Kimura, Tsuyoshi Tsuduki, Phumon Sookwong, Hitoshi Niino, Kayoko Nakayama, Kiyotaka Nakagawa, Miho Nakamura

Publikováno v: Bioscience, Biotechnology, and Biochemistry. 73:2014-2017

Based on the ratios of (-)-epigallocatechin-3-gallate (EGCG) and caffeine (CAF) levels found in commercial tea drinks, EGCG and CAF were co-administered to human volunteers at various EGCG/CAF ratios, and plasma EGCG was determined by high performanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5135c1cb6e7ae014b5bfdb8f9c3ce69
https://doi.org/10.1271/bbb.90195

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Overcoming the polyethylene glycol dilemma via pathological environment-sensitive change of the surface property of nanoparticles for cellular entry

Autor: Mayumi Nakai, Satoshi Morimoto, Kentaro Kogure, Shoko Itakura, Satoko Suzuki, Kayoko Nakayama, Susumu Hama

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 206

Modification with polyethylene glycol (PEG) is currently considered an important strategy for anti-cancer drug delivery, because PEGylated-nanoparticles would be effectively delivered to tumor tissue by enhanced permeation and retention effects. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5792e8099b523d8902d0ebe476df2a
https://pubmed.ncbi.nlm.nih.gov/25770398

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Fusicocca-3(16),10(14)-diene, and β- and δ-Araneosenes, New Fusicoccin Biosynthesis-related Diterpene Hydrocarbons fromPhomopsis amygdali

Autor: Hiromichi Kenmoku, Nobuo Kato, Kayoko Nakayama, Takeshi Sassa

Publikováno v: Bioscience, Biotechnology, and Biochemistry. 68:1608-1610

Further isolation and examination of fusicoccane hydrocarbons biosynthetically related to fusicoccin from Phomopsis amygdali allowed us to identify new fungal diterpene hydrocarbons of fusicoccadiene and araneosene. These were assigned as (+)-fusicoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8acb78519ce1ffc902036e5816e01cd4
https://doi.org/10.1271/bbb.68.1608

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Selectivity in the Extraction of Copper(II) with a New Alkylated 8-Quinolinol Derivative with a Nitrophenylazo Substituent

Autor: Hisanori Imura, Kousaburo Ohashi, Hideyuki Ikeda, Kayoko Nakayama

Publikováno v: Analytical Sciences. 9:355-359

The extraction behavior of MnII, FeIII, CoII, NiII, CuII, ZnII, GaIII, and CdII was studied with a new chelating extractant, 5-(4-nitrophenylazo)-7-(4-ethyl-1-methyloctyl)-8-quinolinol (HNEQ), in chloroform. HNEQ exhibits a much higher extractability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00d07458b8e430f546a2f27c590dd637
https://doi.org/10.2116/analsci.9.355

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A case of primary lesion indistinctness malignant melanoma.A summary of exerienced cases after opening of hospital

Autor: Yusuke Yoshizawa, Kayoko Nakayama, Keijiro Kitamura, Yuriko Okumura

Publikováno v: Skin Cancer. 7:226-229

A rare case of metastatic malignant melanoma of unknown primary origin to the right inguinal lymph nodes was reported. Although the melanoma was largely developed dimensioned 20×15×7cm, after extensive chemotherapy combined with radiotherapy and hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c87f1ac95ae36c838700d539fb11a9a0
https://doi.org/10.5227/skincancer.7.226

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Abstract 3873: Squalene enhanced chemotherapy and radiation therapy sensitivity in mice through the inhibition of DNA damage checkpoint activity

Autor: Kiyomi Kasai-Eguchi, Naoto Tatewaki, Hiroshi Nishida, Nobuo Ikekawa, Yuki Nakajima, Kazunori Anzai, Kayoko Nakayama-Kawakami, Tetsuya Konishi

Publikováno v: Cancer Research. 70:3873-3873

ATM (Ataxia Telangiectasia Mutated) protein kinase plays a crucial role in cellular DNA damage responses. The inhibition of ATM leads to an abolishment of one such signal pathways termed as “checkpoints”. It is expected that the discovery of chec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e87c3be9e7ad0d075d32715165404ac4
https://doi.org/10.1158/1538-7445.am10-3873

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