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Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 30:127636

The P2X3 receptor is an attractive target for the treatment of pain and chronic coughing, and thus P2X3 antagonists have been developed as new therapeutic drugs. We previously reported selective P2X3 receptor antagonists by derivatization of hit comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c89d73a5579aa30dce0898c8270420b
https://doi.org/10.1016/j.bmcl.2020.127636

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Nucleophilic attack of intramolecular hydroxyl groups on electron-rich aromatics using hypervalent iodine(III) oxidation

Autor: Simon B. Caemmerer, Yasuyuki Kita, Hiromi Hamamoto, Kayoko Hata, Yukiko Shiozaki

Publikováno v: Tetrahedron. 63:4052-4060

The hypervalent iodine(III) reagent, phenyliodine bis(trifluoroacetate) (PIFA)-mediated oxidative nucleophilic substitution of electron-rich aromatics involving aromatic cation radical intermediates was utilized in the direct aromatic carbon–oxygen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ca39ac81a2e4719b8b5c2aac7e9ff8
https://doi.org/10.1016/j.tet.2007.02.118

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The Efficient Synthesis of Morphinandienone Alkaloids by Using a Combination of Hypervalent Iodine(III) Reagent and Heteropoly Acid

Autor: Hirofumi Tohma, Yasuyuki Kita, Yukiko Shiozaki, Hiromi Hamamoto, Kayoko Hata, Hisanori Nambu

Publikováno v: Chemistry - A European Journal. 10:4977-4982

The non-phenolic coupling reaction of benzyltetrahydroisoquinolines (laudanosine derivatives) by using a hypervalent iodine(III) reagent is described. In general, chemical oxidation of laudanosine gives glaucine. In contrast to general chemical oxidi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e4aa66cd02180dcc4238c333d4a517
https://doi.org/10.1002/chem.200400358

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A novel and direct synthesis of chroman derivatives using a hypervalent iodine(III) reagent

Autor: Yukiko Shiozaki, Hiromi Hamamoto, Kayoko Hata, Hirofumi Tohma, Yasuyuki Kita, Hisanori Nambu

Publikováno v: Tetrahedron Letters. 45:2293-2295

The direct aromatic carbon–oxygen bond-formation reaction was described and the novel and simple synthetic method for chroman derivatives involving aromatic cation radical intermediates was developed using the hypervalent iodine(III) reagent, pheny

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e221c6831cb6e63dfa886154237b2ee
https://doi.org/10.1016/j.tetlet.2004.01.104

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Organic synthesis using a hypervalent iodine reagent: unexpected and novel domino reaction leading to spiro cyclohexadienone lactones

Autor: Taeko Nakamura, Kenichi Murai, Akihito Miyoshi, Yasuyuki Kita, Jnashuara Ganesh, Kayoko Hata, Hideyuki Komatsu, Hiromichi Fujioka

Publikováno v: Chemical communications (Cambridge, England). 46(23)

The reaction of 1-(p-hydroxyaryl)cyclobutanols and phenyl iodide(III) diacetate in hexafluoroisopropanol and water produced spiro cyclohexadienone lactones via a domino reaction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b010e073292eb0d97aeddce4c73c6239
https://pubmed.ncbi.nlm.nih.gov/20520878

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ChemInform Abstract: The Direct Synthesis of Thioesters Using an Intermolecular Radical Reaction of Aldehydes with Dipentafluorophenyl Disulfide in Water

Autor: Hisanori Nambu, Kayoko Hata, Masato Matsugi, Yasuyuki Kita

Publikováno v: ChemInform. 33

The combination of the water-soluble radical initiator, 2,2′-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (VA–044), and surfactant, cetyltrimethylammonium bromide (CTAB), was found to be the most suitable condition for the effective direc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::febf044bd6b815581682c61a297a0cad
https://doi.org/10.1002/chin.200235092

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Facile and Efficient Synthesis of Lactols by a Domino Reaction of 2,3-Epoxy Alcohols with a Hypervalent Iodine(III) Reagent and Its Application to the Synthesis of Lactones and the Asymmetric Synthesis of (+)-Tanikolide

Autor: Eri Fujii, Kayoko Hata, Mai Horai, Natsuko Nishiguchi, Hiromichi Fujioka, Satoshi Matsuda, Yasuyuki Kita, Maiko Morishita

Publikováno v: ChemInform. 38

The domino reaction of 2,3-epoxy-1-alcohol derivatives, namely tetrasubstituted 2,3-epoxy-1-alcohols and 2- or 3-alkyl trisubstituted 2,3-epoxy-1-alcohols, with PhI(OCOCF(3))(2) in the presence of H(2)O is described in detail. In this reaction, sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9204f41ef674d1f0d20e9d55b073a121
https://doi.org/10.1002/chin.200741111

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Hypervalent Iodine(III) Reagent Promoted Rearrangement and Subsequent Oxidative Ring Cleavage of Cyclic 2,3-Epoxy-1-alcohol Derivatives

Autor: Satoshi Matsuda, Hiromichi Fujioka, Shinji Kitagaki, Ryoko Inoguchi, Kayoko Hata, Eri Fujii, Yasuyuki Kita

Publikováno v: ChemInform. 37

The rearrangements of 2,3-epoxy alcohol derivatives were achieved using the hypervalent iodine(III) reagent, phenyliodine(III) b:is(trifluoroacetate) (PIFA). In the case of 2,3-epoxy alcohols subsequent oxidative ring cleavage occurred to give ω-for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53f10d93afa3246955772469d38c4297
https://doi.org/10.1002/chin.200623054

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