Výsledky vyhledávání - "Kayo Umekawa"

Design, synthesis and biological activity of novel non-peptidyl endothelin converting enzyme inhibitors, 1-phenyl-tetrazole-formazan analogues

Autor: Hirohiko Hasegawa, Masaharu Kanaoka, Kazuto Yamazaki, Yasuyuki Ueki, Kayo Umekawa, Naohito Ohashi

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 12:1275-1278

A novel non-peptidyl endothelin converting enzyme inhibitor was obtained through a pharmacophore analysis of known inhibitors and three-dimensional structure database search. Analogues of the new inhibitor were designed using the structure-activity r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1dc72c8b7adc928e9422fd60d06496
https://doi.org/10.1016/s0960-894x(02)00149-x

Zobrazit plný text záznamu

Pharmacological Characterization of a Novel Sulfonylureid-Pyrazole Derivative, SM-19712, a Potent Nonpeptidic Inhibitor of Endothelin Converting Enzyme

Autor: Kayo Umekawa, Hirohiko Hasegawa, Yasuo Matsumura, Kimihiko Sato, Yasushi Tsutsumi, Naohito Ohashi

Publikováno v: Japanese Journal of Pharmacology. 84:7-15

We describe the pharmacological characteristics of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt). SM-19712 inhibited endothelin converting enzyme (ECE) solubilized from rat lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcce9360f3080eec701e4647b75b014a
https://doi.org/10.1254/jjp.84.7

Zobrazit plný text záznamu

ChemInform Abstract: Design, Synthesis and Biological Activity of Novel Non-Peptidyl Endothelin Converting Enzyme Inhibitors, 1-Phenyl-tetrazole-formazan Analogues (VIII)

Autor: Kayo Umekawa, Naohito Ohashi, Masaharu Kanaoka, Hirohiko Hasegawa, Kazuto Yamazaki, Yasuyuki Ueki

Publikováno v: ChemInform. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87e558b4b5f8942d0bba2e3e98dc8120
https://doi.org/10.1002/chin.200231144

Zobrazit plný text záznamu

Protective effect of SM-19712, a novel and potent endothelin converting enzyme inhibitor, on ischemic acute renal failure in rats

Autor: Yasuo Matsumura, Kayo Umekawa, Naohito Ohashi, Toshihiko Kuro, Masanori Takaoka, Yutaka Kobayashi

Publikováno v: Japanese journal of pharmacology. 84(1)

Effects of SM-19712 {4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-lH-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt}, a novel endothelin converting enzyme (ECE) inhibitor, on ischemic acute renal failure (ARF) in rats were examined in co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64add9db6bb27538dd13d818e327b33
https://pubmed.ncbi.nlm.nih.gov/11043448

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání