Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kaylyn M. Bauer"'
Autor:
Jian-Gang Ren, Bowen Xing, Kaosheng Lv, Rachel A. O’Keefe, Mengfang Wu, Ruoxing Wang, Kaylyn M. Bauer, Arevik Ghazaryan, George M. Burslem, Jing Zhang, Ryan M. O’Connell, Vinodh Pillai, Elizabeth O. Hexner, Mark R. Philips, Wei Tong
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
RAS mutations are among the most prevalent oncogenic drivers in cancers. RAS proteins propagate signals only when associated with cellular membranes as a consequence of lipid modifications that impact their trafficking. Here, we discovered that RAB27
Externí odkaz:
https://doaj.org/article/636f9f226afa48728696c139c7a0044c
Autor:
Arevik Ghazaryan, Jared A. Wallace, William W. Tang, Cindy Barba, Soh-Hyun Lee, Kaylyn M. Bauer, Morgan C. Nelson, Carissa N. Kim, Chris Stubben, Warren P. Voth, Dinesh S. Rao, Ryan M. O’Connell
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Acute myeloid leukemia (AML) is a heterogeneous and deadly disease characterized by uncontrolled expansion of malignant blasts. Altered metabolism and dysregulated microRNA (miRNA) expression profiles are both characteristic of AML. However, there is
Externí odkaz:
https://doaj.org/article/7398a18c853e402d9edaebb274d37ba5
Autor:
Kaylyn M. Bauer, Morgan C. Nelson, William W. Tang, Tyson R. Chiaro, D. Garrett Brown, Arevik Ghazaryan, Soh-Hyun Lee, Allison M. Weis, Jennifer H. Hill, Kendra A. Klag, Van B. Tran, Jacob W. Thompson, Andrew G. Ramstead, Josh K. Monts, James E. Marvin, Margaret Alexander, Warren P. Voth, W. Zac Stephens, Diane M. Ward, Aaron C. Petrey, June L. Round, Ryan M. O’Connell
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Intercellular communication is critical for homeostasis in mammalian systems, including the gastrointestinal (GI) tract. Exosomes are nanoscale lipid extracellular vesicles that mediate communication between many cell types. Notably, the roles of imm
Externí odkaz:
https://doaj.org/article/28e27534285f41e8b7743abd9a89a3a7
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The rising toll of cancer globally necessitates ingenuity in early detection and therapy. In the last decade, the utilization of immune signatures and immune-based therapies has made significant progress in the clinic; however, clinical standards lea
Externí odkaz:
https://doaj.org/article/e139d0f509124008a685df0dc9188772
Autor:
Thomas B. Huffaker, H. Atakan Ekiz, Cindy Barba, Soh-Hyun Lee, Marah C. Runtsch, Morgan C. Nelson, Kaylyn M. Bauer, William W. Tang, Timothy L. Mosbruger, James E. Cox, June L. Round, Warren P. Voth, Ryan M. O’Connell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
IFNy can polarize macrophages in the tumour microenvironment to an inflammatory state and thereby contributes to their anti-tumour function. Here the authors show an underlying mechanism in this process is IFNy-driven STAT1 occupancy and activation o
Externí odkaz:
https://doaj.org/article/b194e57208eb4a39a01b6f84ed5db4cc
Autor:
W. Zac Stephens, Jason L. Kubinak, Arevik Ghazaryan, Kaylyn M. Bauer, Rickesha Bell, Kate Buhrke, Tyson R. Chiaro, Allison M. Weis, William W. Tang, Josh K. Monts, Ray Soto, H. Atakan Ekiz, Ryan M. O’Connell, June L. Round
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109916- (2021)
Summary: Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC cl
Externí odkaz:
https://doaj.org/article/c1e5d4d89cc84888a5fa9fbe24b048c9
Autor:
Jacob W. Thompson, Ruozhen Hu, Thomas B. Huffaker, Andrew G. Ramstead, H. Atakan Ekiz, Kaylyn M. Bauer, William W. Tang, Arevik Ghazaryan, June L. Round, Robert S. Fujinami, Ryan M. O’Connell
Publikováno v:
The Journal of Immunology. 210:926-934
The proinflammatory microRNA-155 (miR-155) is highly expressed in the serum and CNS lesions of patients with multiple sclerosis (MS). Global knockout (KO) of miR-155 in mice confers resistance to a mouse model of MS, experimental autoimmune encephalo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c53bba1a134ba5dc42deaaf2cfbc8551
https://doi.org/10.4049/jimmunol.2200478
https://doi.org/10.4049/jimmunol.2200478
Autor:
Andrew G. Ramstead, Jared A. Wallace, Soh-Hyun Lee, Kaylyn M. Bauer, William W. Tang, H. Atakan Ekiz, Thomas E. Lane, Ahmad A. Cluntun, Matthew L. Bettini, June L. Round, Jared Rutter, Ryan M. O’Connell
Publikováno v:
Cell Reports, Vol 30, Iss 9, Pp 2889-2899.e6 (2020)
Summary: Metabolic pathways regulate T cell development and function, but many remain understudied. Recently, the mitochondrial pyruvate carrier (MPC) was identified as the transporter that mediates pyruvate entry into mitochondria, promoting pyruvat
Externí odkaz:
https://doaj.org/article/85eca401df46476092567316c9937106
Autor:
Andrew W. Harrington, Michael R. McKain, Daniel Michalski, Kaylyn M. Bauer, Joshua M. Daugherty, Mindy Steiniger
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-16 (2017)
Abstract Background Endogenous small interfering (esi)RNAs repress mRNA levels and retrotransposon mobility in Drosophila somatic cells by poorly understood mechanisms. 21 nucleotide esiRNAs are primarily generated from retrotransposons and two inver
Externí odkaz:
https://doaj.org/article/5cde7f883e694a36b9e028743c022082
Autor:
Marah C Runtsch, Morgan C Nelson, Soh-Hyun Lee, Warren Voth, Margaret Alexander, Ruozhen Hu, Jared Wallace, Charisse Petersen, Vanja Panic, Claudio J Villanueva, Kimberley J Evason, Kaylyn M Bauer, Timothy Mosbruger, Sihem Boudina, Mary Bronner, June L Round, Micah J Drummond, Ryan M O'Connell
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007970 (2019)
Identifying regulatory mechanisms that influence inflammation in metabolic tissues is critical for developing novel metabolic disease treatments. Here, we investigated the role of microRNA-146a (miR-146a) during diet-induced obesity in mice. miR-146a
Externí odkaz:
https://doaj.org/article/0b801b0c45b84c1488fd88a3d64a9028