Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kaylyn M Bauer"'
Autor:
Marah C Runtsch, Morgan C Nelson, Soh-Hyun Lee, Warren Voth, Margaret Alexander, Ruozhen Hu, Jared Wallace, Charisse Petersen, Vanja Panic, Claudio J Villanueva, Kimberley J Evason, Kaylyn M Bauer, Timothy Mosbruger, Sihem Boudina, Mary Bronner, June L Round, Micah J Drummond, Ryan M O'Connell
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007970 (2019)
Identifying regulatory mechanisms that influence inflammation in metabolic tissues is critical for developing novel metabolic disease treatments. Here, we investigated the role of microRNA-146a (miR-146a) during diet-induced obesity in mice. miR-146a
Externí odkaz:
https://doaj.org/article/0b801b0c45b84c1488fd88a3d64a9028
Autor:
Jian-Gang Ren, Bowen Xing, Kaosheng Lv, Rachel A. O’Keefe, Mengfang Wu, Ruoxing Wang, Kaylyn M. Bauer, Arevik Ghazaryan, George M. Burslem, Jing Zhang, Ryan M. O’Connell, Vinodh Pillai, Elizabeth O. Hexner, Mark R. Philips, Wei Tong
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
RAS mutations are among the most prevalent oncogenic drivers in cancers. RAS proteins propagate signals only when associated with cellular membranes as a consequence of lipid modifications that impact their trafficking. Here, we discovered that RAB27
Externí odkaz:
https://doaj.org/article/636f9f226afa48728696c139c7a0044c
Autor:
Arevik Ghazaryan, Jared A. Wallace, William W. Tang, Cindy Barba, Soh-Hyun Lee, Kaylyn M. Bauer, Morgan C. Nelson, Carissa N. Kim, Chris Stubben, Warren P. Voth, Dinesh S. Rao, Ryan M. O’Connell
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Acute myeloid leukemia (AML) is a heterogeneous and deadly disease characterized by uncontrolled expansion of malignant blasts. Altered metabolism and dysregulated microRNA (miRNA) expression profiles are both characteristic of AML. However, there is
Externí odkaz:
https://doaj.org/article/7398a18c853e402d9edaebb274d37ba5
Autor:
Kaylyn M. Bauer, Morgan C. Nelson, William W. Tang, Tyson R. Chiaro, D. Garrett Brown, Arevik Ghazaryan, Soh-Hyun Lee, Allison M. Weis, Jennifer H. Hill, Kendra A. Klag, Van B. Tran, Jacob W. Thompson, Andrew G. Ramstead, Josh K. Monts, James E. Marvin, Margaret Alexander, Warren P. Voth, W. Zac Stephens, Diane M. Ward, Aaron C. Petrey, June L. Round, Ryan M. O’Connell
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Intercellular communication is critical for homeostasis in mammalian systems, including the gastrointestinal (GI) tract. Exosomes are nanoscale lipid extracellular vesicles that mediate communication between many cell types. Notably, the roles of imm
Externí odkaz:
https://doaj.org/article/28e27534285f41e8b7743abd9a89a3a7
Autor:
Jacob W. Thompson, Ruozhen Hu, Thomas B. Huffaker, Andrew G. Ramstead, H. Atakan Ekiz, Kaylyn M. Bauer, William W. Tang, Arevik Ghazaryan, June L. Round, Robert S. Fujinami, Ryan M. O’Connell
Publikováno v:
The Journal of Immunology. 210:926-934
The proinflammatory microRNA-155 (miR-155) is highly expressed in the serum and CNS lesions of patients with multiple sclerosis (MS). Global knockout (KO) of miR-155 in mice confers resistance to a mouse model of MS, experimental autoimmune encephalo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c53bba1a134ba5dc42deaaf2cfbc8551
https://doi.org/10.4049/jimmunol.2200478
https://doi.org/10.4049/jimmunol.2200478
Autor:
Andrew W. Harrington, Michael R. McKain, Daniel Michalski, Kaylyn M. Bauer, Joshua M. Daugherty, Mindy Steiniger
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-16 (2017)
Abstract Background Endogenous small interfering (esi)RNAs repress mRNA levels and retrotransposon mobility in Drosophila somatic cells by poorly understood mechanisms. 21 nucleotide esiRNAs are primarily generated from retrotransposons and two inver
Externí odkaz:
https://doaj.org/article/5cde7f883e694a36b9e028743c022082
Autor:
Tyson R. Chiaro, Kaylyn M. Bauer, Kyla S. Ost, Emmanuel Stephen-Victor, Morgan C. Nelson, Jennifer H. Hill, Rickesha Bell, Morgan Harwood, Warren Voth, Taylor Jackson, Kendra A Klag, Ryan M. O’Connell, W. Zac Stephens, June L. Round
Publikováno v:
bioRxiv
SUMMARYRegulation of the microbiota is critical to intestinal health yet the mechanisms employed by innate immunity remain unclear. Here we show that mice deficient in the C-Type-lectin receptor, Clec12a developed severe colitis, which was dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1f6f83e6b69bc3240b7d317804f7ff
https://europepmc.org/articles/PMC10055051/
https://europepmc.org/articles/PMC10055051/
Publikováno v:
Frontiers in Immunology. 13
The rising toll of cancer globally necessitates ingenuity in early detection and therapy. In the last decade, the utilization of immune signatures and immune-based therapies has made significant progress in the clinic; however, clinical standards lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee365c74421cac079a57d994db7fa55f
https://doi.org/10.3389/fimmu.2022.929677
https://doi.org/10.3389/fimmu.2022.929677
Autor:
Jared Wallace, Ryan M. O'Connell, H. Atakan Ekiz, Dinesh S. Rao, Soh-Hyun Lee, Micah J. Drummond, Morgan C. Nelson, June L. Round, Ruozhen Hu, Andrew G. Ramstead, Kaylyn M. Bauer, Jared Rutter
Publikováno v:
J Immunol
Aging-related chronic inflammation is a risk factor for many human disorders through incompletely understood mechanisms. Aged mice deficient in microRNA (miRNA/miR)-146a succumb to life-shortening chronic inflammation. In this study, we report that m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df68690f80804187c37fda9d4cb2410
https://doi.org/10.4049/jimmunol.1901484
https://doi.org/10.4049/jimmunol.1901484
Publikováno v:
The FEBS journal. 289(14)
Extracellular communication is critical to the function of an organism. Exosomes, small lipid extracellular vesicles, have been recently appreciated to participate in this vital function. Within these vesicles lie critical bioactive molecules includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be7c3850bccebef028f1d5f9de049c1
https://pubmed.ncbi.nlm.nih.gov/34087046
https://pubmed.ncbi.nlm.nih.gov/34087046