Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kaylyn E. Williamson"'
Autor:
Megan A. Frederick, Kaylyn E. Williamson, Meilin Fernandez Garcia, Max B. Ferretti, Ryan L. McCarthy, Greg Donahue, Edgar Luzete Monteiro, Naomi Takenaka, Janice Reynaga, Cigall Kadoch, Kenneth S. Zaret
Publikováno v:
Nature Structural & Molecular Biology. 30:31-37
Autor:
Patrick Trojer, Barbara M. Bryant, Danette L. Daniels, David Stokoe, Steven Magnuson, Thomas O'Brien, Thomas M. Edwards, Charlie Hatton, Shilpi Arora, Shobu Odate, Srividya Balasubramanian, Kaylyn E. Williamson, John P. McGrath
Lysine-specific demethylase 1 (KDM1A) is a transcriptional coregulator that can function in both the activation and repression of gene expression, depending upon context. KDM1A plays an important role in hematopoiesis and was identified as a dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa8a610fc2d1e8853a7290e6d74095e
https://doi.org/10.1158/0008-5472.c.6507927.v1
https://doi.org/10.1158/0008-5472.c.6507927.v1
Autor:
Patrick Trojer, Barbara M. Bryant, Danette L. Daniels, David Stokoe, Steven Magnuson, Thomas O'Brien, Thomas M. Edwards, Charlie Hatton, Shilpi Arora, Shobu Odate, Srividya Balasubramanian, Kaylyn E. Williamson, John P. McGrath
Includes Supplementary Methods, Supplementary Tables and Figures and References Supplementary Figure 1: Structure and enzyme inhibitory activity of the KDM1A tool compounds. Supplementary Figure 2: CETSA shows thermal stabilization of KDM1A in intact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ad7b062c053bb3b56ba1bd985056d8
https://doi.org/10.1158/0008-5472.22410150
https://doi.org/10.1158/0008-5472.22410150
Autor:
Patrick Trojer, Barbara M. Bryant, Danette L. Daniels, David Stokoe, Steven Magnuson, Thomas O'Brien, Thomas M. Edwards, Charlie Hatton, Shilpi Arora, Shobu Odate, Srividya Balasubramanian, Kaylyn E. Williamson, John P. McGrath
Supplementary Table S1: Gene expression changes in Kasumi-1 and SKNO-1 cells upon treatment with RN-1, GSK690 and GSK690* for 24 and 72 hours compared to DMSO-treated controls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86203d415f557a18d1d7d1c33c2e01b1
https://doi.org/10.1158/0008-5472.22410147.v1
https://doi.org/10.1158/0008-5472.22410147.v1
Autor:
Jennifer A. Mertz, Stefan A. Kirov, Kaylyn E. Williamson, Marton Munz, Robert J. Sims, Michaela Bowden
Publikováno v:
Cancer Research. 83:2802-2802
Targeting lineage-defined transcription factors with small molecules is a proven and effective therapeutic strategy, as demonstrated by estrogen and androgen receptor therapies for breast and prostate cancers. Expression of the transcription factor P
Autor:
Megan A, Frederick, Kaylyn E, Williamson, Meilin, Fernandez Garcia, Max B, Ferretti, Ryan L, McCarthy, Greg, Donahue, Edgar, Luzete Monteiro, Naomi, Takenaka, Janice, Reynaga, Cigall, Kadoch, Kenneth S, Zaret
Publikováno v:
Nature structuralmolecular biology.
To determine how different pioneer transcription factors form a targeted, accessible nucleosome within compacted chromatin and collaborate with an ATP-dependent chromatin remodeler, we generated nucleosome arrays in vitro with a central nucleosome co
Autor:
Christopher A. Moskaluk, Michael J. Wick, Matthew J. Cotton, Michael J. Kluk, Shawn M. Gillespie, Kaylyn E. Williamson, William C. Faquin, Christopher D. Carey, Lurdes Queimado, Jun Qi, Russell J.H. Ryan, Yotam Drier, Lynette M. Sholl, Jon C. Aster, Scott J. Rodig, Adel K. El-Naggar, James E. Bradner, A. Afrogheh, Bradley E. Bernstein, Birgit Knoechel
Publikováno v:
Nature genetics
Translocation events are frequent in cancer and may create chimeric fusions or ‘regulatory rearrangements’ that drive oncogene overexpression. Here we identify super-enhancer translocations that drive overexpression of the oncogenic transcription
Autor:
Miguel Rivera, Emily C. Hartman, Monica Schenone, Hubert Pakula, William C. Hahn, Roodolph St. Pierre, John L. Pulice, Gabriel J. Sandoval, Gaylor Boulay, Kaylyn E. Williamson, Matthew J. McBride, Lucienne Ronco, Joshua Pan, Steven A. Carr, David Y. Takeda, Levi A. Garraway, Zhe Li, Marius S. Pop, Cigall Kadoch
Chromosomal rearrangements resulting in the fusion of TMPRSS2, an androgen-regulated gene, and the ETS family transcription factor ERG occur in over half of prostate cancers. However, the mechanism by which ERG promotes oncogenic gene expression and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9983134db72a9a2bc8569a321cae28b9
https://europepmc.org/articles/PMC6140332/
https://europepmc.org/articles/PMC6140332/
Autor:
Barbara M. Bryant, Patrick Trojer, Emmanuel Normant, Richard T. Cummings, Nico Cantone, Victor S. Gehling, William D. Bradley, Les A. Dakin, Rishi G. Vaswani, Chih-Chi Yuan, Kaylyn E. Williamson, Robert E. Campbell, Jean-Christophe Harmange, James E. Audia, Jacqui Méndez, Jennifer Busby, Christopher G. Nasveschuk, Feng Zhao, Danette L. Daniels, Brian K. Albrecht, Shivani Garapaty-Rao, Andrew S. Cook, Charlie Hatton, Srividya Balasubramanian, Shilpi Arora, Priyadarshini Iyer
Publikováno v:
Chemistry & Biology. 21(11):1463-1475
SummaryThe histone lysine methyltransferase (MT) Enhancer of Zeste Homolog 2 (EZH2) is considered an oncogenic driver in a subset of germinal center B-cell-like diffuse large B cell lymphoma (GCB-DLBCL) and follicular lymphoma due to the presence of
Autor:
Matthew J. Cotton, Shawn M. Gillespie, Michael J. Kluk, Mohit Jain, Bradley E. Bernstein, Dale L. Greiner, Daniel S. Pearson, Michael A. Brehm, Serena J. Silver, Manching Ku, Jens G. Lohr, Andrew L. Kung, Federica Piccioni, Alejandro Gutierrez, Daniel Fernandez, Jiang Zhu, Kimberly Stegmaier, Christopher J. Ott, Kaylyn E. Williamson, Hongfang Wang, David E. Root, Michelle A. Kelliher, Jon C. Aster, James E. Bradner, Justine E. Roderick, Birgit Knoechel, Leonard D. Shultz
Publikováno v:
Nature Genetics. 46:364-370
The identification of activating NOTCH1 mutations in T cell acute lymphoblastic leukemia (T-ALL) led to clinical testing of γ-secretase inhibitors (GSIs) that prevent NOTCH1 activation. However, responses to these inhibitors have been transient, sug