Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kaylyn D. Tousignant"'
Autor:
Peter R. Sternes, Ayesha Shah, Camila Ayala Pintos, Thomas Fairlie, Natasha Koloski, Seungha Kang, Kaylyn D. Tousignant, Simon J. McIlroy, Mark Morrison, Gene W. Tyson, Gerald J. Holtmann
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionLittle is known about the biogeography of the mucosa associated microbiome (MAM) in patients with inflammatory bowel disease (IBD) versus controls in different segments of the gastrointestinal tract, as well as the links between the MAM,
Externí odkaz:
https://doaj.org/article/e6d4fa5f911b470eb6fac7120c5d1523
Autor:
Reuben S.E. Young, Andrew P. Bowman, Kaylyn D. Tousignant, Berwyck L.J. Poad, Jennifer H. Gunter, Lisa K. Philp, Colleen C. Nelson, Shane R. Ellis, Ron M.A. Heeren, Martin C. Sadowski, Stephen J. Blanksby
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 6, Pp 100223- (2022)
The cellular energy and biomass demands of cancer drive a complex dynamic between uptake of extracellular FAs and their de novo synthesis. Given that oxidation of de novo synthesized FAs for energy would result in net-energy loss, there is an implica
Externí odkaz:
https://doaj.org/article/fee2b5d060ce47b7a34577bf15b24534
Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer
Autor:
Kaylyn D. Tousignant, Anja Rockstroh, Berwyck L. J. Poad, Ali Talebi, Reuben S. E. Young, Atefeh Taherian Fard, Rajesh Gupta, Tuo Zang, Chenwei Wang, Melanie L. Lehman, Johan V. Swinnen, Stephen J. Blanksby, Colleen C. Nelson, Martin C. Sadowski
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-21 (2020)
Abstract Background Metabolic reprograming, non-mutational epigenetic changes, increased cell plasticity, and multidrug tolerance are early hallmarks of therapy resistance in cancer. In this temporary, therapy-tolerant state, cancer cells are highly
Externí odkaz:
https://doaj.org/article/c6e2a3ea96274cda8079bc82f329c973
Autor:
Reuben S.E. Young, Andrew P. Bowman, Elizabeth D. Williams, Kaylyn D. Tousignant, Charles L. Bidgood, Venkateswara R. Narreddula, Rajesh Gupta, David L. Marshall, Berwyck L.J. Poad, Colleen C. Nelson, Shane R. Ellis, Ron M.A. Heeren, Martin C. Sadowski, Stephen J. Blanksby
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108738- (2021)
Summary: Canonical fatty acid metabolism describes specific enzyme-substrate interactions that result in products with well-defined chain lengths, degree(s), and positions of unsaturation. Deep profiling of lipids across a range of prostate cancer ce
Externí odkaz:
https://doaj.org/article/27b8a1a8bbb5417e805cadd5a720a7a8
Autor:
Martin C. Sadowski, Colleen C. Nelson, Marcel E. Dinger, Nenad Bartonicek, Lisa K. Philp, Stephen J. McPherson, Chenwei Wang, Melanie L. Lehman, Atefeh Taherian Fard, Anja Rockstroh, Kaylyn D. Tousignant
Figure S1: LNCaP, VCaP and DuCaP cells were grown in charcoal-dextran stripped serum (CSS) for 48 h and treated with increasing concentrations of R1881 or DHT in the presence or absence of Enzalutamide (10 µM) or vehicle (Ctrl) for 48 h. Figure S2:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110d167333fec1a49913df2360f93a80
https://doi.org/10.1158/1541-7786.22513437.v1
https://doi.org/10.1158/1541-7786.22513437.v1
Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer
Autor:
Berwyck L. J. Poad, Ali Talebi, Melanie Lehman, Kaylyn D. Tousignant, Johan Swinnen, Tuo Zang, Martin C. Sadowski, Rajesh Gupta, Chenwei Wang, Colleen C. Nelson, Stephen J. Blanksby, Atefeh Taherian Fard, Reuben S. E. Young, Anja Rockstroh
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-21 (2020)
Cancer & Metabolism
Cancer & Metabolism
BackgroundMetabolic reprograming, non-mutational epigenetic changes, increased cell plasticity and multidrug tolerance are early hallmarks of therapy resistance in cancer. In this temporary, therapy-tolerant state, cancer cells are highly sensitive t
Autor:
Kaylyn D. Tousignant, Stephen J. Blanksby, Ron M. A. Heeren, Jennifer H. Gunter, Reuben S. E. Young, Lisa Philp, Shane R. Ellis, Berwyck L. J. Poad, Martin C. Sadowski, Andrew P. Bowman, Colleen C. Nelson
1.0SummaryCellular energy and biomass demands of cancer drive a complex dynamic between uptake of extracellular fatty acids (FA) and de novo synthesis. Given that oxidation of de novo synthesised FAs for energy would result in net-energy loss, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c72b6552667db3bc8163fe480b071bdd
https://doi.org/10.1101/2021.11.01.466716
https://doi.org/10.1101/2021.11.01.466716
Autor:
Stephen McPherson, Marcel E. Dinger, Chenwei Wang, Martin C. Sadowski, Kaylyn D. Tousignant, Anja Rockstroh, Atefeh Taherian Fard, Lisa Philp, Nenad Bartonicek, Colleen C. Nelson, Melanie Lehman
Publikováno v:
Molecular Cancer Research. 17:1166-1179
De novo lipogenesis is a well-described androgen receptor (AR)–regulated metabolic pathway that supports prostate cancer tumor growth by providing fuel, membrane material, and steroid hormone precursor. In contrast, our current understanding of lip
Autor:
David L. Marshall, Andrew P. Bowman, Reuben S. E. Young, Rajesh Gupta, Colleen C. Nelson, Shane R. Ellis, Ron M. A. Heeren, Kaylyn D. Tousignant, Martin C. Sadowski, Charles L. Bidgood, Stephen J. Blanksby, Venkateswara R. Narreddula, Elizabeth D. Williams, Berwyck L. J. Poad
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108738-(2021)
Young, Reuben S E; Bowman, Andrew P; Williams, Elizabeth D; Tousignant, Kaylyn D; Bidgood, Charles L; Narreddula, Venkateswara R; Gupta, Rajesh; Marshall, David L; Poad, Berwyck L J; Nelson, Colleen C; Ellis, Shane R; Heeren, Ron M A; Sadowski, Martin C; Blanksby, Stephen J (2021). Apocryphal FADS2 activity promotes fatty acid diversification in cancer. Cell reports, 34(6), p. 108738. Cell Press 10.1016/j.celrep.2021.108738
Cell Reports, 34(6):108738. Cell Press
Young, Reuben S E; Bowman, Andrew P; Williams, Elizabeth D; Tousignant, Kaylyn D; Bidgood, Charles L; Narreddula, Venkateswara R; Gupta, Rajesh; Marshall, David L; Poad, Berwyck L J; Nelson, Colleen C; Ellis, Shane R; Heeren, Ron M A; Sadowski, Martin C; Blanksby, Stephen J (2021). Apocryphal FADS2 activity promotes fatty acid diversification in cancer. Cell reports, 34(6), p. 108738. Cell Press 10.1016/j.celrep.2021.108738
Cell Reports, 34(6):108738. Cell Press
Canonical fatty acid metabolism describes specific enzyme-substrate interactions that result in products with well-defined chain lengths, degree(s), and positions of unsaturation. Deep profiling of lipids across a range of prostate cancer cell lines
Autor:
Martin C. Sadowski, Venkateswara R. Narreddula, Elizabeth D. Williams, Berwyck L. J. Poad, Rajesh Gupta, Charles L. Bidgood, Reuben S. E. Young, Shane R. Ellis, David L. Marshall, Ron M. A. Heeren, Andrew P. Bowman, Stephen J. Blanksby, Colleen C. Nelson, Kaylyn D. Tousignant
Fatty acid (FA) modifications, such as enzymatic desaturation and elongation, have long been thought to involve sequential and highly specific enzyme-substrate interactions, which result in canonical products that are well-defined in their chain leng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ecc6b36ae7db4a39a4e4d074c51c056
https://doi.org/10.1101/2020.06.07.139089
https://doi.org/10.1101/2020.06.07.139089