Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Kaylene M Young"'
Autor:
Natasha Stevens, Chigozie Ezegbe, Valery Fuh-Ngwa, Kalina Makowiecki, Amin Zarghami, Phuong Tram Nguyen, Julie Sansom, Kate Smith, Laura L. Laslett, Meg Denham, Carlie L. Cullen, Michael H. Barnett, Mark R. Hinder, Monique Breslin, Kaylene M. Young, Bruce V. Taylor
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Background Multiple sclerosis (MS) is a chronic neurological condition and the leading cause of non-traumatic disability in young adults. MS pathogenesis leads to the death of oligodendrocytes, demyelination, and progressive central nervous
Externí odkaz:
https://doaj.org/article/f63bb6c9caf244c59917e3eca9caacc5
Autor:
Carlie L Cullen, Kaylene M Young
Publikováno v:
Frontiers in Neural Circuits, Vol 10 (2016)
Transcranial magnetic stimulation (TMS) is widely used in the clinic, and while it has a direct effect on neuronal excitability, the beneficial effects experienced by patients are likely to include the indirect activation of other cell types. Researc
Externí odkaz:
https://doaj.org/article/860f6779aed747868601ea46b95414b9
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0155878 (2016)
The low density lipoprotein-receptor related protein 1 (LRP1) is a large endocytic cell surface receptor that is known to interact with a variety of ligands, intracellular adaptor proteins and other cell surface receptors to regulate cellular behavio
Externí odkaz:
https://doaj.org/article/c67dbd796ab5469bbb294f1096ee53b1
Autor:
Megan O'Rourke, Carlie L Cullen, Loic Auderset, Kimberley A Pitman, Daniela Achatz, Robert Gasperini, Kaylene M Young
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162858 (2016)
In the central nervous system (CNS) platelet derived growth factor receptor alpha (PDGFRα) is expressed exclusively by oligodendrocyte progenitor cells (OPCs), making the Pdgfrα promoter an ideal tool for directing transgene expression in this cell
Externí odkaz:
https://doaj.org/article/15dcc914951e404485ffac793f62a0ac
Autor:
Natalie E. King, Jo-Maree Courtney, Lachlan S. Brown, Alastair J. Fortune, Nicholas B. Blackburn, Jessica L. Fletcher, Jake M. Cashion, Jana Talbot, Alice Pébay, Alex W. Hewitt, Gary P. Morris, Kaylene M. Young, Anthony L. Cook, Brad A. Sutherland
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background Pericytes are multifunctional contractile cells that reside on capillaries. Pericytes are critical regulators of cerebral blood flow and blood–brain barrier function, and pericyte dysfunction may contribute to the pathophysiolog
Externí odkaz:
https://doaj.org/article/c8c8c85bb5db476ea1a3b1f8afc26262
Autor:
Kalina Makowiecki, Natasha Stevens, Carlie L. Cullen, Amin Zarghami, Phuong Tram Nguyen, Lewis Johnson, Jennifer Rodger, Mark R. Hinder, Michael Barnett, Kaylene M. Young, Bruce V. Taylor
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Background Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease, characterised by oligodendrocyte death and demyelination. Oligodendrocyte progenitor cells can differentiate into new replacement oligodendrocytes; however,
Externí odkaz:
https://doaj.org/article/cc7b2f51d6e840e7a9025424537ce232
Publikováno v:
Neurobiology of Disease, Vol 178, Iss , Pp 106028- (2023)
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system (CNS) and the most common non-traumatic cause of neurological disability in young adults. Multiple sclerosis clinical care has improved considerably due to the
Externí odkaz:
https://doaj.org/article/e0abc73da0d14c3983311cf6163b45a4
Autor:
Yilan Zhen, Carlie L. Cullen, Raphael Ricci, Benjamin S. Summers, Sakina Rehman, Zubair M. Ahmed, Antoinette Y. Foster, Ben Emery, Robert Gasperini, Kaylene M. Young
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-21 (2022)
Protocadherin 15 promotes lamellipodial and filopodial dynamics in oligodendrocyte progenitor cells by regulating Cdc42-Arp2/3 activity, but also suppresses ERK1/2 phosphorylation to reduce proliferation.
Externí odkaz:
https://doaj.org/article/5c6fb3dbd66a477395c3c0828c084902
Autor:
Alastair J. Fortune, Bruce V. Taylor, Jac C. Charlesworth, Kathryn P. Burdon, Nicholas B. Blackburn, Jessica L. Fletcher, Ashish Mehta, Kaylene M. Young
Publikováno v:
Stem Cell Research, Vol 62, Iss , Pp 102828- (2022)
Multiple sclerosis (MS) is a complex neuroinflammatory/degenerative disease of the central nervous system (CNS) that results in the formation of demyelinated lesions and axon degeneration. MS aetiology is complex, with genetics estimated to account f
Externí odkaz:
https://doaj.org/article/36d1e2a617e84d96b7b9aa23c581304b
Autor:
Loic Auderset, Kimberley A. Pitman, Carlie L. Cullen, Renee E. Pepper, Bruce V. Taylor, Lisa Foa, Kaylene M. Young
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Low-density lipoprotein receptor-related protein 1 (LRP1) is a large, endocytic cell surface receptor that is highly expressed by oligodendrocyte progenitor cells (OPCs) and LRP1 expression is rapidly downregulated as OPCs differentiate into oligoden
Externí odkaz:
https://doaj.org/article/a80eab967aa7467ab367559a81457003