Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kayleigh Walker"'
Autor:
Kayleigh Walker, Roberta Baravalle, Rachel Holyfield, Jacqueline Kalms, Helena Wright, Chitra Seewooruthun, Frederick W. Muskett, Anthony Scott-Tucker, Andy Merritt, Alistair Henry, Alastair D. G. Lawson, Gareth Hall, Christine Prosser, Mark D. Carr
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interleukin-13 (IL-13) is a cytokine involved in T-cell immune responses and is a well validated therapeutic target for the treatment of asthma, along with other allergic and inflammatory diseases. IL-13 signals through a ternary signalling complex f
Externí odkaz:
https://doaj.org/article/ed60b6efb669458b96fb34943581aadf
Publikováno v:
Biomolecular NMR assignments. 16(2)
The co-inhibitory immune checkpoint interaction between programmed cell death-protein 1 (PD-1) and programmed cell death-ligand 1 (PD-L1) serves to regulate T-cell activation, promoting self-tolerance. Over-expression of PD-L1 is a mechanism through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc09ef2ff10d45813c45d2fe45d2be92
https://pubmed.ncbi.nlm.nih.gov/35675028
https://pubmed.ncbi.nlm.nih.gov/35675028
Autor:
Tara Kang-Pettinger, Kayleigh Walker, Richard Brown, Richard Cowan, Helena Wright, Roberta Baravalle, Lorna C. Waters, Frederick W. Muskett, Matthew W. Bowler, Kovilen Sawmynaden, Peter J. Coombs, Mark D. Carr, Gareth Hall
Publikováno v:
Journal of Biological Chemistry. 299:102769
Programmed death-ligand 1 (PD-L1) is a key immune regulatory protein that interacts with programmed cell death protein 1 (PD-1), leading to T-cell suppression. Whilst this interaction is key in self-tolerance, cancer cells evade the immune system by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d2423a9d75186022993ce5b2c1159c
https://doi.org/10.1016/j.jbc.2022.102769
https://doi.org/10.1016/j.jbc.2022.102769
Autor:
Derek J Blevins, Fraser Hof, Trevor Bolduc, David A. Powell, Ronan P. Hanley, Michael C. Gignac, Mark D. Carr, Jeremy E. Wulff, Kayleigh Walker
Publikováno v:
ACS Med Chem Lett
[Image: see text] The programmed cell death protein 1 (PD-1) signaling axis is among the most important therapeutic targets in modern oncology. Aurigene Discovery Technologies Ltd. (Aurigene) has patented a series of peptidomimetic small molecules de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb19ca7dea14ef35a8bba6bb8d93313
https://doi.org/10.1021/acsmedchemlett.9b00221
https://doi.org/10.1021/acsmedchemlett.9b00221