Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kayleigh R. McGovern-Gooch"'
Autor:
Melissa Navarro, Maria B. Campaña, Michelle A. Sieburg, Tasha R. Davis, James L. Hougland, Mohammad Ashkar, Rosemary Loftus, Najae Escoffery, Flaviyan Jerome Irudayanathan, Shikha Nangia, Kayleigh R. McGovern-Gooch
Publikováno v:
Journal of Biological Chemistry. 294:14166-14174
Integral membrane proteins represent a large and diverse portion of the proteome and are often recalcitrant to purification, impeding studies essential for understanding protein structure and function. By combining co-evolutionary constraints and com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0b0822a6af9efe92415e438651cf1da
https://doi.org/10.1074/jbc.ac119.009749
https://doi.org/10.1074/jbc.ac119.009749
Autor:
Michelle A. Sieburg, Anthony J. Schramm, Kayleigh R. McGovern-Gooch, Lauren G. Hannah, Nivedita S. Mahajani, James L. Hougland, Ariana Garagozzo, John D. Chisholm
Publikováno v:
Biochemistry. 56:919-931
The peptide hormone ghrelin plays a key role in regulating hunger and energy balance within the body. Ghrelin signaling presents a promising and unexploited target for development of small molecule therapeutics for treatment of obesity, diabetes, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa89a2a1da829a898a401ce35805d80
https://doi.org/10.1021/acs.biochem.6b01008
https://doi.org/10.1021/acs.biochem.6b01008
Autor:
Maria B, Campaña, Flaviyan Jerome, Irudayanathan, Tasha R, Davis, Kayleigh R, McGovern-Gooch, Rosemary, Loftus, Mohammad, Ashkar, Najae, Escoffery, Melissa, Navarro, Michelle A, Sieburg, Shikha, Nangia, James L, Hougland
Publikováno v:
J Biol Chem
Integral membrane proteins represent a large and diverse portion of the proteome and are often recalcitrant to purification, impeding studies essential for understanding protein structure and function. By combining co-evolutionary constraints and com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66bb7a5c75ac41f5d3c9bdc913bbc001
https://pubmed.ncbi.nlm.nih.gov/31413115
https://pubmed.ncbi.nlm.nih.gov/31413115
Autor:
James L. Hougland, Michelle A. Sieburg, Kayleigh R. McGovern-Gooch, Tasha R. Davis, Maria B. Campaña, Mohammad Ashkar, Rosemary Loftus, Najae Escoffery, Flaviyan Jerome Irudayanathan, Melissa Navarro, Shikha Nangia
Integral membrane proteins represent a large and essential portion of the proteome that often prove challenging for structural studies. We demonstrate a synergistic approach to structurally model topologically complex integral membrane proteins by co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc153358e9e8361b5a68dc0aef937bb8
Publikováno v:
Methods
Interrogating non-coding RNA structures and functions with small molecules is an area of rapidly increasing interest among biochemists and chemical biologists. However, many biochemical approaches to monitoring RNA structures are time-consuming and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5126309d783646ee8eac374cc0572b72
https://pubmed.ncbi.nlm.nih.gov/31129289
https://pubmed.ncbi.nlm.nih.gov/31129289
Publikováno v:
Molecular Membrane Biology. 33:111-124
Ghrelin is a small peptide hormone that requires a unique post-translational modification, serine octanoylation, to bind and activate the GHS-R1a receptor. Initially demonstrated to stimulate hunger and appetite, ghrelin-dependent signaling is implic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4ee89c6dc9ea2ce6d5d94f4cc852a4
https://doi.org/10.1080/09687688.2017.1388930
https://doi.org/10.1080/09687688.2017.1388930
Autor:
Michelle A. Sieburg, Joseph E. Darling, Trevor Rodrigues, James L. Hougland, Alfonso Abizaid, Kayleigh R. McGovern-Gooch
Publikováno v:
Endocrinology. 157:4330-4338
Ghrelin is a peptide hormone involved in multiple physiological processes related to energy homeostasis. This hormone features a unique posttranslational serine octanoylation modification catalyzed by the enzyme ghrelin O-acyltransferase, with serine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747f1d7213b6baed476409b33c301d25
https://doi.org/10.1210/en.2016-1657
https://doi.org/10.1210/en.2016-1657