Výsledky vyhledávání - "Kayleigh E. Hall"

The application of (Z)-3-aryl-3-haloenoic acids to the synthesis of (Z)-5-benzylidene-4-arylpyrrol-2(5H)-ones

Autor: Peter J. Barelli, Spencer R. Bates, Edith J. Banner, Nakul Telang, Kayleigh E. Hall, Rebecca Osterman, Kara L. Finzel, Xin Jia, Lauren T. Firich, R. Scott Welden, Matthew B. Coppock, John T. Gupton, John A. Stafford, Eric F. Worrall, Emily J. Kluball, James E. Eaton, Benjamin C. Giglio, Kerry Keertikar, Rene P.F. Kanters

Studies directed at the synthesis of (Z)-5-benzylidene-4-arylpyrrol-2(5H)-ones from (Z)-3-aryl-3-haloenoic acids are described. The successful strategy relies on the preparation of (Z)-3-aryl-3-haloenoic acids from acetophenones through the correspon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d528eea90de2115065c63b0408e9b66
https://europepmc.org/articles/PMC2997076/

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Further studies on vinamidinium salt amine exchange reactions, borohydride reductions and subsequent transformations

Autor: Stanton Q. Smith, Rene P.F. Kanters, Benjamin C. Giglio, Peter J. Barelli, Matthew J. Keough, Emily J. Kluball, Mona Hovaizi, Eric F. Worrall, John T. Gupton, Kara L. Finzel, Shane R. Nunes, James E. Eaton, Xin Jia, Jennifer M. Birnstihl, Timothy M. Smith, R. Scott Welden, Nakul Telang, Kayleigh E. Hall, Mathew T. Wright

Studies directed at the amine exchange reaction of vinamidinium salts followed by sodium borohydride reduction to secondary and tertiary allylic amines are described. The tertiary allylic amines were alkylated and subjected to base mediated rearrange

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6777fb421a1979c14de522b4f5d3b1
https://europepmc.org/articles/PMC2990967/

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Developing novel C-4 analogues of pyrrole-based antitubulin agents: weak but critical hydrogen bonding in the colchicine site

Autor: Peter J. Barelli, John T. Gupton, Susan L. Mooberry, Kara L. Finzel, Emily J. Kluball, Xin Jia, Chenxiao Da, Nakul Telang, Kayleigh E. Hall, Glen E. Kellogg

Publikováno v: MedChemComm. 4:417

The synthesis, biological evaluation and molecular modeling of a series of pyrrole compounds related to 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid that evaluates and optimizes C-4 substituents are reported. The key factor for mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926e891e18fc431ab17fb90632eab367
https://doi.org/10.1039/c2md20320k

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