Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kayleen S. Kott"'
Autor:
Anne A Knowlton, Kayleen S. Kott, Katherine W. Ferrara, Le Chen, Zulfiqar A. Malik, Tiffany Kuo, Adam J. Poe
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 304:H954-H965
Exosomes, which are 50- to 100-nm-diameter lipid vesicles, have been implicated in intercellular communication, including transmitting malignancy, and as a way for viral particles to evade detection while spreading to new cells. Previously, we demons
Publikováno v:
Pediatric Pulmonology. 43:760-766
Cysteinyl leukotrienes promote airway inflammation, bronchoconstriction and mucus hypersecretion. Cigarette smoking and respiratory syncytial virus (RSV) bronchiolitis are known to increase urinary cysteinyl leukotriene E4 (uLTE4), the end product of
Autor:
Kent E. Pinkerton, John M. Bric, Laurel J. Gershwin, Janice L. Peake, Charles G. Plopper, Kayleen S. Kott, Edward S. Schelegle, Jesse P. Joad
Publikováno v:
Toxicology and Applied Pharmacology. 226:153-160
Inhaled corticosteroids (ICS) are recommended to treat infants with asthma, some with intermittent asthma. We previously showed that exposing infant monkeys to allergen/ozone resulted in asthma-like characteristics of their airways. We evaluated the
Autor:
Edward S. Schelegle, Charles G. Plopper, Kayleen S. Kott, Jesse P. Joad, Kent E. Pinkerton, Laurel J. Gershwin, John M. Bric, Janice L. Peake
Publikováno v:
Toxicology and Applied Pharmacology. 214:237-243
Both allergen and ozone exposure increase asthma symptoms and airway responsiveness in children. Little is known about how these inhalants may differentially modify airway responsiveness in large proximal as compared to small distal airways. We evalu
Publikováno v:
Journal of Applied Physiology. 87:757-768
Children chronically exposed to environmental tobacco smoke (ETS) have more coughs, wheezes, and airway obstruction, which may result in part from stimulation of lung C fibers. We examined the effect of chronic exposure to sidestream tobacco smoke (S
Publikováno v:
The Journal of Physiology. 503:635-643
1. Substance P induces fluid flux via nitric oxide, and fluid flux stimulates lung rapidly adapting receptors (RARs). We therefore proposed that nitric oxide contributes to substance P-evoked increases in RAR activity. Since substance P decreases dyn
Publikováno v:
Toxicology and Applied Pharmacology. 141:561-567
We studied the local role of C-fibers, in the absence of systemic effects and blood components of inflammation, on lung responses to ozone. Guinea pigs were pretreated with capsaicin to deplete C-fibers or with vehicle. One week later their isolated,
Publikováno v:
The Journal of Physiology. 493:229-238
1. This study tested the hypothesis that substance P stimulates rapidly adapting receptors (RARs), contributes to the increase in RAR activity produced by mild pulmonary congestion, and evokes an augmented response from RARs when combined with near-t
Publikováno v:
Toxicology and Applied Pharmacology. 132:63-71
We evaluated whether sidestream smoke (SS) exposure in utero and/or postnatally causes airway obstruction and hyperresponsiveness, and whether the effect is associated with neuroendocrine cell hyperplasia. Pregnant Sprague-Dawley rats were exposed to
Autor:
Jesse P. Joad, Ann C. Bonham, Shin Ichi Sekizawa, Kayleen S. Kott, Dallas M. Hyde, Rick C. Tham, Andrea G. Bechtold
Publikováno v:
Toxicology and applied pharmacology. 247(3)
Allergic airway diseases in children are a common and a growing health problem. Changes in the central nervous system (CNS) have been implicated in contributing to some of the symptoms. We hypothesized that airway allergic diseases are associated wit