Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kaylee B. Worlock"'
Autor:
Puja Mehta, Blanca Sanz-Magallón Duque de Estrada, Emma K. Denneny, Kane Foster, Carolin T. Turner, Andreas Mayer, Martina Milighetti, Manuela Platé, Kaylee B. Worlock, Masahiro Yoshida, Jeremy S. Brown, Marko Z. Nikolić, Benjamin M. Chain, Mahdad Noursadeghi, Rachel C. Chambers, Joanna C. Porter, Gillian S. Tomlinson
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundPersistent radiological lung abnormalities are evident in many survivors of acute coronavirus disease 2019 (COVID-19). Consolidation and ground glass opacities are interpreted to indicate subacute inflammation whereas reticulation is though
Externí odkaz:
https://doaj.org/article/0c20d7c4f93849d0869626a0bd37c791
Autor:
Rik G.H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, Masahiro Yoshida, David Scobie, Helen R. Wagstaffe, Laura Richardson, Anna Wilbrey-Clark, Josephine L. Barnes, Krzysztof Polanski, Jessica Allen-Hyttinen, Puja Mehta, Dinithi Sumanaweera, Jacqueline Boccacino, Waradon Sungnak, Ni Huang, Lira Mamanova, Rakesh Kapuge, Liam Bolt, Elena Prigmore, Ben Killingley, Mariya Kalinova, Maria Mayer, Alison Boyers, Alex Mann, Vitor Teixeira, Sam M. Janes, Rachel C. Chambers, Muzlifah Haniffa, Andrew Catchpole, Robert Heyderman, Mahdad Noursadeghi, Benny Chain, Andreas Mayer, Kerstin B. Meyer, Christopher Chiu, Marko Z. Nikolić, Sarah A. Teichmann
The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the cellular disease dynamics remains limited. In our unique COVID-19 human challenge study we used single cell genomics of nasopharyngeal swabs and blood to temporall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d220950228bcc70a9b7e6d3734f32b9f
https://doi.org/10.1101/2023.04.13.23288227
https://doi.org/10.1101/2023.04.13.23288227
Autor:
Puja Mehta, Blanca Sanz-Magallón Duque de Estrada, Emma K Denneny, Kane Foster, Carolin T Turner, Andreas Mayer, Martina Milighetti, Manuela Platé, Kaylee B Worlock, Masahiro Yoshida, Jeremy S Brown, Marko Z Nikolić, Arjun Nair, Benjamin M Chain, Mahdad Noursadeghi, Rachel C Chambers, Joanna C Porter, Gillian S Tomlinson
RationalePersistent pulmonary sequelae are evident in many survivors of acute coronavirus disease 2019 (COVID-19) but the molecular mechanisms responsible are incompletely understood. Post-COVID radiological lung abnormalities comprise two broad cate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a9a38043410cc595cc35362b5a61e02
https://doi.org/10.1101/2023.03.28.23287759
https://doi.org/10.1101/2023.03.28.23287759
Autor:
Maximillian Woodall, Ana-Maria Cujba, Kaylee B. Worlock, Katie-Marie Case, Tereza Masonou, Masahiro Yoshida, Krzysztof Polanski, Ni Huang, Rik G. H. Lindeboom, Lira Mamanova, Liam Bolt, Laura Richardson, Samuel Ellis, Machaela Palor, Thomas Burgoyne, Andreia Pinto, Dale Moulding, Timothy D. McHugh, Aarash Saleh, Eliz Kilich, Puja Mehta, Chris O’Callaghan, Jie Zhou, Wendy Barclay, Paolo De Coppi, Colin R. Butler, Heloise Vinette, Sunando Roy, Judith Breuer, Rachel C. Chambers, Wendy E. Heywood, Kevin Mills, Robert E. Hynds, Sarah A. Teichmann, Kerstin B. Meyer, Marko Z. Nikolić, Claire M. Smith
Children infected with SARS-CoV-2 rarely progress to respiratory failure, but the risk of mortality in infected people over 85 years of age remains high, despite vaccination and improving treatment options. Here, we take a comprehensive, multidiscipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d879062a84c842d555af5dd10e4eba88
https://doi.org/10.1101/2023.01.16.524211
https://doi.org/10.1101/2023.01.16.524211
Autor:
Josephine L. Barnes, Peng He, Masahiro Yoshida, Kaylee B. Worlock, Rik G.H. Lindeboom, Chenqu Suo, J. Patrick Pett, Anna Wilbrey-Clark, Emma Dann, Lira Mamanova, Laura Richardson, Amanda J. Oliver, Adam Pennycuick, Jessica Allen-Hyttinen, Iván T. Herczeg, Robert E. Hynds, Vitor H. Teixeira, Muzlifah Haniffa, Kyungtae Lim, Dawei Sun, Emma L. Rawlins, Krzysztof Polanski, Paul A. Lyons, John C. Marioni, Zewen Kelvin Tuong, Menna R. Clatworthy, James L. Reading, Sam M. Janes, Sarah A. Teichmann, Kerstin B. Meyer, Marko Z. Nikolić
During human development, lungs develop their roles of gas exchange and barrier function. Recent single cell studies have focused on epithelial and mesenchymal cell types, but much less is known about the developing lung immune cells, although the ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba9e470f99f21542bfed3c556bfdae9f
https://doi.org/10.1101/2022.12.13.519713
https://doi.org/10.1101/2022.12.13.519713
Autor:
Andrey Tvardovskiy, Manuel Beltran, Richard G. Jenner, Neil Justin, Till Bartke, Javier Herrero, Manuel Tavares, Simone Kunzelmann, Steven J. Gamblin, Benjamin M. Foster, John Ambrose, Kaylee B Worlock, Garima Khandelwal, Jon R. Wilson
Publikováno v:
Nature structural & molecular biology
Nat. Struct. Mol. Biol. 26, 899-909 (2019)
Nat. Struct. Mol. Biol. 26, 899-909 (2019)
Polycomb repressive complex 2 (PRC2) maintains repression of cell-type-specific genes but also associates with genes ectopically in cancer. While it is currently unknown how PRC2 is removed from genes, such knowledge would be useful for the targeted
Autor:
Rgh Lindeboom, BC Jones, Muzlifah Haniffa, Laura Richardson, C Dominguez Conde, JP Pett, Sean B. Smith, Elo Madissoon, V Chu, Ca Gao, Aarash Saleh, Sarah Teichmann, Krzysztof Polanski, Eliz Kilich, A-K Reuschl, Jessica Allen-Hyttinen, Neil J. Sebire, Kerstin B. Meyer, H Yung, Alexander V. Misharin, A Saigal, Clatworthy, Clare Jolly, Jane Dematte, Waradon Sungnak, C Cane, Marko Nikolic, Colin R. Butler, Ni Huang, Puja Mehta, Claire Smith, Elena Prigmore, Natsuhiko Kumasaka, Fernando J Calero-Nieto, Taylor A. Poor, Josephine Barnes, S Shibuya, NU Script Study Investigators, Kaylee B Worlock, AC Argento, Anna Wilbrey-Clark, A Iordanidou, Sam M. Janes, P De Coppi, Matthew L Coates, Jonathan M. Cohen, Liam Bolt, Lira Mamanova, Masahiro Yoshida, Berthold Göttgens, Gary Reynolds, Richard G. Wunderink, Christopher O'Callaghan, Georgina Bowyer, A de Wilton
Publikováno v:
BTS/BALR/AUK-BLF Early Career Investigator Symposium.
T1 Figure 1ConclusionsOverall, this largest paediatric single cell COVID-19 study to date showed significant differences in response to SARS-CoV-2 between children and adults, reflecting the changes of the immune landscape over developmental time, wh
Autor:
Sarah A. Teichmann, Gary Reynolds, Krzysztof Polanski, Celine Gomez, Kerstin B. Meyer, Masahiro Yoshida, Sam Barnett, Ni Huang, Natsuhiko Kumasaka, Berthold Göttgens, Fernando J Calero-Nieto, Tzachi Hagai, Rachel Boyd, Kaylee B Worlock, Jeremy Schwartzentruber, Sharad R. Patel, Marko Nikolic, Josephine Barnes, Maya Ghoussaini, Nikolaos Panousis, Muzlifah Haniffa, John C. Marioni, Oliver Stegle, Emily Stephenson, Paul A. Lyons, Raghd Rostom
Common genetic variants modulate the cellular response to viruses and are implicated in a range of immune pathologies, including infectious and autoimmune diseases. The transcriptional antiviral response is known to vary between infected cells from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a041afb7a3b06b18a0a564ee4a2de6bf
https://doi.org/10.1101/2021.09.01.457774
https://doi.org/10.1101/2021.09.01.457774
This modified protocol provides details on the cell dissociation that should be performed to obtain single-cell suspensions from nasal, tracheal and bronchial epithelium brushings. Cell dissociation is performed at 4°C to avoid gene expression alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5618ff45bfdd1e0d30c14364370d3ea0
https://doi.org/10.17504/protocols.io.btpunmnw
https://doi.org/10.17504/protocols.io.btpunmnw
Autor:
Liam Bolt, Vivian Chu, Laura Richardson, Lira Mamanova, Masahiro Yoshida, Marko Nikolic, Puja Mehta, Taylor A. Poor, Waradon Sungnak, Natsuhiko Kumasaka, Fernando J Calero-Nieto, Muzlifah Haniffa, Neil J. Sebire, Berthold Göttgens, Kaylee B Worlock, Brendan C Jones, Alexander V. Misharin, Claire Smith, Georgina Bowyer, A. Christine Argento, Sarah A. Teichmann, Rik G.H. Lindeboom, Krzysztof Polanski, Elena Prigmore, Jessica Allen-Hyttinen, Kerstin B. Meyer, Eliz Kilich, Clare Jolly, Gary Reynolds, Elo Madissoon, Henry Yung, Jonathan M. Cohen, Paolo De Coppi, Jane Dematte, Colin R. Butler, Richard G. Wunderink, Jan Patrick Prett, Ni Huang, Sam M. Janes, Matthew L Coates, Anna Wilbrey-Clark, Aarash Saleh, Soichi Shibuya, Catherine A Gao, Ann-Kathrin Reuschl, Menna R. Clatworthy, Angus de Wilton, A Saigal, Cecilia Domínguez Conde, Aikaterini Iordanidou, Josephine Barnes, Sean B. Smith, Clare Cane, NU Script Study Investigators
While a substantial proportion of adults infected with SARS-CoV-2 progress to develop severe disease, children rarely manifest respiratory complications. Therefore, understanding differences in the local and systemic response to SARS-CoV-2 infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4491bbbb170925bd61ea9bd4f80b6d47
https://doi.org/10.1101/2021.03.09.21253012
https://doi.org/10.1101/2021.03.09.21253012