Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kayla Townsley"'
Autor:
Kolter Grigsby, Courtney Ledford, Tanvi Batish, Snigdha Kanadibhotla, Delaney Smith, Evan Firsick, Alexander Tran, Kayla Townsley, Kaylee-Abril Vasquez Reyes, Katherine LeBlanc, Angela Ozburn
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11084 (2022)
Previous studies (1) support a role of circadian genes in regulating alcohol intake, and (2) reveal that harmful alcohol use alters circadian rhythms. However, there is minimal knowledge of the effects of chronic alcohol processes on rhythmic circadi
Externí odkaz:
https://doaj.org/article/d649779c8a9c4f9da74644d011bd5d16
Autor:
PJ Michael Deans, Carina Seah, Jessica Johnson, Judit Garcia Gonzalez, Kayla Townsley, Evan Cao, Nadine Schrode, Eli Stahl, Paul O’Reilly, Laura M. Huckins, Kristen J. Brennand
Publikováno v:
medRxiv
Genetic studies of schizophrenia (SCZ) reveal a complex polygenic risk architecture comprised of hundreds of risk variants, the majority of which are common in the population at-large and confer only modest increases in disorder risk. Precisely how g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3041b80568541df9600aaf3475e813
https://doi.org/10.1101/2023.03.20.23287497
https://doi.org/10.1101/2023.03.20.23287497
Autor:
Kayla Townsley, Aiqun Li, PJ Michael Deans, John F. Fullard, Alex Yu, Sam Cartwright, Minghui Wang, Georgios Voloudakis, Kiran Girdhar, Schahram Akbarian, Eli Stahl, Panos Roussos, Bin Zhang, Laura Huckins, Kristen J. Brennand
Publikováno v:
European Neuropsychopharmacology. 63:e65-e66
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d7eb3a327c3437462b6f0f837f58bbf
https://doi.org/10.1016/j.euroneuro.2022.07.126
https://doi.org/10.1016/j.euroneuro.2022.07.126
Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk
Autor:
Kayla Townsley, Rahat Elahi, Samuel K. Powell, Seok-Man Ho, Paul A. Slesinger, Kristina Dobrindt, Tova Lambert, Laura M. Huckins, Kristen J. Brennand, Callan O’Shea, Aditi Valada, Schahram Akbarian, Will Liao, Iya Prytkova, Marina Iskhakova
Publikováno v:
Molecular Psychiatry.
Dopaminergic neurons are critical to movement, mood, addiction, and stress. Current techniques for generating dopaminergic neurons from human induced pluripotent stem cells (hiPSCs) yield heterogenous cell populations with variable purity and inconsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0638d0783de5458efe4f9ba98001f21
https://doi.org/10.1038/s41380-021-01273-0
https://doi.org/10.1038/s41380-021-01273-0
Autor:
Kiran Girdhar, Biao Zeng, James M. Vicari, Gabriel E. Hoffman, Samir Rahman, Michael B. Fernando, John F. Fullard, Kristen J. Brennand, Georgios Voloudakis, Pengfei Dong, Jaroslav Bendl, Wen Zhang, Kayla Townsley, Pasha Apontes, Panos Roussos, Vahram Haroutunian, Ruth Misir
Identification of risk variants for neuropsychiatric diseases within enhancers underscores the importance of understanding the population-level variation of enhancers in the human brain. Besides regulating tissue- and cell-type-specific transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d596e22b6434f2e8d6e6b3026c864036
https://doi.org/10.1101/2021.05.14.443421
https://doi.org/10.1101/2021.05.14.443421
Publikováno v:
Nat Neurosci
Complex brain disorders are highly heritable and arise from a complex polygenic risk architecture. Many disease-associated loci are found in non-coding regions that house regulatory elements. These elements influence the transcription of target genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d19ba8b482b67bc19e4b840c3e45e4
https://pubmed.ncbi.nlm.nih.gov/33199899
https://pubmed.ncbi.nlm.nih.gov/33199899
Autor:
Callan O’Shea, Kristina Dobrindt, Rahat Elahi, Kristen J. Brennand, Laura M. Huckins, Iya Prytkova, Samuel K. Powell, Schahram Akbarian, Paul A. Slesinger, Kayla Townsley
Publikováno v:
European Neuropsychopharmacology. 51:e50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e45cf84d80e274da708c6a145db5242
https://doi.org/10.1016/j.euroneuro.2021.07.111
https://doi.org/10.1016/j.euroneuro.2021.07.111
Autor:
Marliette R. Matos, P J Michael Deans, Samuel Cartwright, Seok-Man Ho, Kristen J. Brennand, Alex J. Yu, Kayla Townsley, Bin Zhang, Nadine Schrode, Meilin Fernandez Garcia, Aiqun Li
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100580-(2021)
STAR Protocols
STAR Protocols
Summary We describe a CRISPR inhibition (CRISPRi) protocol to repress endogenous gene expression (e.g., ATP6V1A) in human induced pluripotent stem cell-derived NGN2-induced glutamatergic neurons. CRISPRi enables efficient and precise gene repression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9d40a4e1caaadef2235659c70fffce
https://doi.org/10.1016/j.xpro.2021.100580
https://doi.org/10.1016/j.xpro.2021.100580