Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kayla R Gogarty"'
Autor:
Zhuo Zhang, Alvaro A Ordonez, Peter Smith-Jones, Hui Wang, Kayla R Gogarty, Fereidoon Daryaee, Lauren E Bambarger, Yong S Chang, Sanjay K Jain, Peter J Tonge
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170871 (2017)
5-[18F]F-pyrazinamide (5-[18F]F-PZA), a radiotracer analog of the first-line tuberculosis drug pyrazinamide (PZA), was employed to determine the biodistribution of PZA using PET imaging and ex vivo analysis. 5-[18F]F-PZA was synthesized in 60 min usi
Externí odkaz:
https://doaj.org/article/b645b581b9464ab5b1df345ed1325e5c
Autor:
Hui Wang, James N. Iuliano, Sanjay K. Jain, Alvaro A. Ordonez, Fereidoon Daryaee, Yong Li, Grace E. Yoon, Kayla R. Gogarty, Jonathan Merino, Peter Smith-Jones, Edward A. Weinstein, Zhuo Zhang, Alvin S. Kalinda, Peter J. Tonge, Ronnie C. Mease
Publikováno v:
ACS Infectious Diseases. 4:1635-1644
Staphylococcus aureus is the leading cause of life-threatening infections, frequently originating from unknown or deep-seated foci. Source control and institution of appropriate antibiotics remain challenges, especially with infections due to methici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5283430cabb7ff515268a45537df39e
https://doi.org/10.1021/acsinfecdis.8b00182
https://doi.org/10.1021/acsinfecdis.8b00182
Autor:
Kayla R. Gogarty, Stewart L. Fisher, Jonathan Merino, Yong Li, Fereidoon Daryaee, Zhuo Zhang, Peter J. Tonge
Publikováno v:
Chemical Science. 8:3434-3443
Correlating target engagement with in vivo drug activity remains a central challenge in efforts to improve the efficiency of drug discovery. Previously we described a mechanistic pharmacokinetic–pharmacodynamic (PK/PD) model that used drug–target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1684ff881fe21a852d411af2ce3bda06
https://doi.org/10.1039/c6sc03306g
https://doi.org/10.1039/c6sc03306g
Autor:
Zhuo, Zhang, Alvaro A, Ordonez, Hui, Wang, Yong, Li, Kayla R, Gogarty, Edward A, Weinstein, Fereidoon, Daryaee, Jonathan, Merino, Grace E, Yoon, Alvin S, Kalinda, Ronnie C, Mease, James N, Iuliano, Peter M, Smith-Jones, Sanjay K, Jain, Peter J, Tonge
Publikováno v:
ACS Infectious Diseases
Staphylococcus aureus is the leading cause of life-threatening infections, frequently originating from unknown or deep-seated foci. Source control and institution of appropriate antibiotics remain challenges, especially with infections due to methici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::183d55830accdc62591938750fba774d
https://pubmed.ncbi.nlm.nih.gov/30067329
https://pubmed.ncbi.nlm.nih.gov/30067329
Publikováno v:
Imaging Infections ISBN: 9783319545905
PET imaging is likely to be a valuable tool for informing multi-compartment PK analysis by directly providing tissue drug concentration as a function of time, enabling a better understanding of the quantitative relationship between drug doses, time,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ced1eb86e6f361a52e62abbfd0d8ee7
https://doi.org/10.1007/978-3-319-54592-9_9
https://doi.org/10.1007/978-3-319-54592-9_9
Autor:
Lauren E. Bambarger, Kayla R. Gogarty, Zhuo Zhang, Peter Smith-Jones, Peter J. Tonge, Yong S. Chang, Alvaro A. Ordonez, Hui Wang, Sanjay K. Jain, Fereidoon Daryaee
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170871 (2017)
PLoS ONE
PLoS ONE
5-[18F]F-pyrazinamide (5-[18F]F-PZA), a radiotracer analog of the first-line tuberculosis drug pyrazinamide (PZA), was employed to determine the biodistribution of PZA using PET imaging and ex vivo analysis. 5-[18F]F-PZA was synthesized in 60 min usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6326d9b6da98f398bf0fab613a250fb7
http://europepmc.org/articles/PMC5289470?pdf=render
http://europepmc.org/articles/PMC5289470?pdf=render