Výsledky vyhledávání - "Kayla N. Ellefsen"

Subtherapeutic Acetazolamide Doses as a Noninvasive Method for Assessing Medication Adherence

Autor: Christopher D. Verrico, Jennifer R. Schroeder, Aidan J. Hampson, David H. Epstein, Kayla N. Ellefsen, Luba Yammine, Kenzie L. Preston, Marilyn A. Huestis

Publikováno v: Clin Pharmacol Ther

Adherence monitoring is a vital component of clinical efficacy trials, as the regularity of medication consumption affects both efficacy and adverse effect profiles. Pill-counts do not confirm consumption, and invasive plasma assessments can only ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1cb63ff7c0ef0938bb6050570c71a8
https://pubmed.ncbi.nlm.nih.gov/32496573

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Oral fluid cocaine and benzoylecgonine concentrations following controlled intravenous cocaine administration

Autor: Kayla N. Ellefsen, Marta Concheiro, Marilyn A. Huestis, Sandrine Pirard, David A. Gorelick

Publikováno v: Forensic Science International. 260:95-101

Limited oral fluid (OF) pharmacokinetic data collected with commercially available collection devices after controlled cocaine administration hinder OF result interpretations. Ten cocaine-using adults provided OF, collected with Oral-Eze ® (OE) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7a6ea7c728b5f26e6d163b3c8fdd87
https://doi.org/10.1016/j.forsciint.2016.01.013

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Cocaine and metabolite concentrations in DBS and venous blood after controlled intravenous cocaine administration

Autor: David A. Gorelick, Marta Concheiro, Jose Luiz Costa, Sebastien Anizan, Kayla N. Ellefsen, Allan J. Barnes, Sandrine Pirard, Marilyn A. Huestis

Publikováno v: Bioanalysis. 7:2041-2056

Background: DBS are an increasingly common clinical matrix. Methods & results: Sensitive and specific methods for DBS and venous blood cocaine and metabolite detection by LC–HRMS and 2D GC–MS, respectively, were validated to examine correlation b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217a85380fafd4274ea539300a5c68fb
https://doi.org/10.4155/bio.15.127

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4-Methoxy-α-PVP: in silico prediction, metabolic stability, and metabolite identification by human hepatocyte incubation and high-resolution mass spectrometry

Autor: Marta Concheiro, Madeleine J. Swortwood, Ariane Wohlfarth, Kayla N. Ellefsen, Marilyn A. Huestis, Xingxing Diao

Publikováno v: Forensic Toxicology

Novel psychoactive substances are continuously developed to circumvent legislative and regulatory efforts. A new synthetic cathinone, 4-methoxy-α-PVP, was identified for the first time in illegal products; however, the metabolism of this compound is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5778258bcdc583a7a77dca9abce33ec
https://doi.org/10.1007/s11419-015-0287-4

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Quantification of methylone and metabolites in rat and human plasma by liquid chromatography-tandem mass spectrometry

Autor: Joshua S. Elmore, Marilyn A. Huestis, Kayla N. Ellefsen, Marta Concheiro, Masaki Suzuki, Kenner C. Rice, Michael H. Baumann

Publikováno v: Forensic Toxicology. 33:202-212

Methylone is a commonly abused synthetic cathinone derivative marketed as a “legal” alternative to “ecstasy” or cocaine. Previous studies examined the metabolism of methylone in vitro and in vivo; 4-hydroxy-3-methoxymethcathinone (HMMC) was i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a4cb8f3e58439405f67cdb009e80598
https://doi.org/10.1007/s11419-015-0263-z

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Acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide YY and relationships with cardiorespiratory and subjective responses

Autor: Sandrine Pirard, Lorenzo Leggio, Kayla N. Ellefsen, Marilyn A. Huestis, Sofia Bouhlal, David A. Gorelick, Mikela B. Sheskier, Erick Singley

Publikováno v: Drug and alcohol dependence. 180

Background Food intake and use of drugs of abuse like cocaine share common central and peripheral physiological pathways. Appetitive hormones play a major role in regulating food intake; however, little is known about the effects of acute cocaine adm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145adc8a8f0d8a32db62f2ce9f923e02
https://pubmed.ncbi.nlm.nih.gov/28881319

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Method validation of the biochip array technology for synthetic cannabinoids detection in urine

Autor: Nathalie A. Desrosiers, Kayla N. Ellefsen, Sebastien Anizan, Kevin L. Klette, Thomas M. Martin, Marisol S. Castaneto, Marilyn A. Huestis

Publikováno v: Bioanalysis. 6:2919-2930

Background: Synthetic cannabinoids (SC) are widely-abused cannabimimetic drugs that do not screen positive in traditional cannabinoids immunoassays, making detection difficult. Methods and results: The first commercially-available immunoassay for uri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0a8cffa4736a61362664b57cf4333d
https://doi.org/10.4155/bio.14.150

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Validation of the only commercially available immunoassay for synthetic cathinones in urine: Randox Drugs of Abuse V Biochip Array Technology

Autor: Kayla N. Ellefsen, Nathalie A. Desrosiers, Thomas M. Martin, Marisol S. Castaneto, Sebastien Anizan, Kevin L. Klette, Marilyn A. Huestis

Publikováno v: Drug Testing and Analysis. 6:728-738

Deterrence of synthetic cathinone abuse is hampered by the lack of a high-throughput immunoassay screen. The Randox Drugs of Abuse V (DOA-V) Biochip Array Technology contains two synthetic cathinone antibodies: Bath Salt I (BSI) targets mephedrone/me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9854c9b42e8142efc0fd8d9e01e0a735
https://doi.org/10.1002/dta.1633

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