Výsledky vyhledávání - "Kayla McEnery"

Supplementary Figure 6 from miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma

Autor: Amy B. Heimberger, George A. Calin, Gregory N. Fuller, Ganesh Rao, Frederick F. Lang, Nicholas B. Levine, Wei Qiao, Olsi Gjyshi, Krishan Jethwa, Kayla McEnery, Yuhui Yang, Sherise D. Ferguson, Tiffany Doucette, Shuo Xu, Ling-Yuan Kong, Fei Wang, Jun Wei

Supplementary Figure 6 - PDF file 131K,viR-124 modulates Th1, Th17, and inducible Treg differentiation. CD4+CD45RA+CD45RO-na�ve T-cells were isolated from healthy donor PBMCs and stimulated with plate-bound anti-CD3 and soluble anti-CD28 under Th1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3e5cf4bb31e13338b9d9ca3b0bd0bb
https://doi.org/10.1158/0008-5472.22394868.v1

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Supplementary Figure 4 from miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma

Supplementary Figure 4 - PDF file 84K, Ex vivo splenocytes from miR-124 treated intracranial GL261 mice have markedly increased cytotoxicity at 48 hour s after coculture with GL261 cells compared to splenocytes from scramble control oligonucleotide-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e4d91b21ee28fb269b3e6ae2eb8ebb
https://doi.org/10.1158/0008-5472.22394874

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Supplementary Figure 2 from miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma

Supplementary Figure 2 - PDF file 25K, Schema demonstrating how miR-124 exerts target effects on the STAT3 pathway in gCSC cells. STAT3 can be activated by a variety of ligands such as IL-6 or EGFR. miR-124 can not only down-modulate SHC1, STAT3, P-S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68141f416a318618ebd29cf02edb7ca5
https://doi.org/10.1158/0008-5472.22394880

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Supplementary Figure 5 from miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma

Supplementary Figure 5 - PDF file 77K, Up regulation of miR-124 level and down regulation of p-STAT3 in peripheral blood T-cells and glioma- infiltrating T-cells after intravenous administration of miR- 124. (A) The miR-124 expression level is below

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019e24b66cbbf0435812b5ef8abd2d2d
https://doi.org/10.1158/0008-5472.22394871.v1

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Supplementary Figure 1 from miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma

Supplementary Figure 1. PDF file 49K, (A) The relative expression of miR-124 as detected by TaqMan quantitative PCR in the CD11b+ GBM-infiltrating microglia/macrophages (n=4) is either very low or undetectable compared to normal brain tissues (n=3) (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a693b6581318695bbaec2174fa4db95
https://doi.org/10.1158/0008-5472.22394883

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Supplementary Figure 3 from miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma

Supplementary Figure 3 - PDF file 37K, miR-21 expression is higher in gCSCs and glioblastoma tumors than in normal brain and is inhibited by miR-124 overexpression. (A) Relative expression levels of miR-21 were detected by TaqMan quantitative P CR. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5001dba63c1c50aa19635332a8af9f7b
https://doi.org/10.1158/0008-5472.22394877

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Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease

Autor: Kayla McEnery, Jili Zhu, Binghua Li, Peter Igarashi, Alysha Rauhauser, Komal Vadnagara, Dongmei Lu, Sarah Elhadi, Massimo Attanasio, Chongyu Ren, Moumita Chaki, Anton M. Jetten

Publikováno v: Kidney International. 89:1307-1323

Enlargement of kidney tubules is a common feature of multiple cystic kidney diseases in humans and mice. However, while some of these pathologies are characterized by cyst expansion and organ enlargement, in others, progressive interstitial fibrosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49db88dfe59ce10f6733c586cfa4dd8
https://doi.org/10.1016/j.kint.2016.03.006

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miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma

Autor: Tiffany Doucette, Krishan Jethwa, George A. Calin, Amy B. Heimberger, Fei Wang, Sherise D. Ferguson, Ling Yuan Kong, Gregory N. Fuller, Shuo Xu, Olsi Gjyshi, Yuhui Yang, Nicholas B. Levine, Wei Qiao, Ganesh Rao, Jun Wei, Frederick F. Lang, Kayla McEnery

Publikováno v: Cancer Research. 73:3913-3926

miRNAs (miR) have been shown to modulate critical gene transcripts involved in tumorigenesis, but their role in tumor-mediated immunosuppression is largely unknown. On the basis of miRNA gene expression in gliomas using tissue microarrays, in situ hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3990e93ebcda0bd4ce42f838c756b430
https://doi.org/10.1158/0008-5472.can-12-4318

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miRNA-mediated immune regulation and immunotherapeutic potential in glioblastoma

Autor: Kayla McEnery, Jun Wei, Amy B. Heimberger, Krishan Jethwa

Publikováno v: Clinical Investigation. 1:1637-1650

Glioblastoma (GB), the most common primary neoplasm of the CNS, remains universally fatal with standard therapies and has a mean overall survival time of only 14.6 months. Even in the most favorable situations most patients do not survive longer than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c17a90e830d8d42ccbe4f9eb1511fd
https://doi.org/10.4155/cli.11.159

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