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Autor:
Cheryl J. Smith, Elizabeth Spehalski, Mary J. Morgan, Jeffrey Buis, David O. Ferguson, JoAnn Sekiguchi, Kayla M. Capper, Maria Dinkelmann
Publikováno v:
Cancer research. 77(19)
Hypomorphic mutations in the genes encoding the MRE11/RAD50/NBS1 (MRN) DNA repair complex lead to cancer-prone syndromes. MRN binds DNA double-strand breaks, where it functions in repair and triggers cell-cycle checkpoints via activation of the ataxi