Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kayla G. Sprenger"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2669-2679 (2024)
HIV-1 can rapidly infect the brain upon initial infection, establishing latent reservoirs that induce neuronal damage and/or death, resulting in HIV-Associated Neurocognitive Disorder. Though anti-HIV-1 antiretrovirals (ARVs) suppress viral load, the
Externí odkaz:
https://doaj.org/article/16081dd8318742cfaf5225af558840bb
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionWith the flood of engineered antibodies, there is a heightened need to elucidate the structural features of antibodies that contribute to specificity, stability, and breadth. While antibody flexibility and interface angle have begun to be
Externí odkaz:
https://doaj.org/article/92fb3da14eb5413e943634e81846d800
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Highly mutable infectious disease pathogens (hm-IDPs) such as HIV and influenza evolve faster than the human immune system can contain them, allowing them to circumvent traditional vaccination approaches and causing over one million deaths annually.
Externí odkaz:
https://doaj.org/article/e0d0a5d75cbe40ce8d3ab11f03f9d3fe
Autor:
Simone Conti, Victor Ovchinnikov, Jonathan G. Faris, Arup K. Chakraborty, Martin Karplus, Kayla G. Sprenger
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4 (2022)
The design of vaccines against highly mutable pathogens, such as HIV and influenza, requires a detailed understanding of how the adaptive immune system responds to encountering multiple variant antigens (Ags). Here, we describe a multiscale model of
Externí odkaz:
https://doaj.org/article/1fb711c145304bb7a7da516379116abf
Autor:
Brian M. Petersen, Sophia A. Ulmer, Emily R. Rhodes, Matias F. Gutierrez-Gonzalez, Brandon J. Dekosky, Kayla G. Sprenger, Timothy A. Whitehead
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Monoclonal antibodies (mAbs) are an important class of therapeutics used to treat cancer, inflammation, and infectious diseases. Identifying highly developable mAb sequences in silico could greatly reduce the time and cost required for therapeutic mA
Externí odkaz:
https://doaj.org/article/10a36cfa20ad4ada87c052c6b7e5c904
The design of vaccines against highly mutable pathogens, such as HIV and influenza, requires a detailed understanding of how the adaptive immune system responds to encountering multiple variant antigens (Ags). Here, we describe a multiscale model of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0c064a5d6d287b5fa3ac56ed1ab7e31
https://doi.org/10.1101/2021.09.01.458482
https://doi.org/10.1101/2021.09.01.458482
Autor:
Simone Conti, Victor Ovchinnikov, Jonathan G. Faris, Arup K. Chakraborty, Martin Karplus, Kayla G. Sprenger
Publikováno v:
PLoS computational biology. 18(4)
The design of vaccines against highly mutable pathogens, such as HIV and influenza, requires a detailed understanding of how the adaptive immune system responds to encountering multiple variant antigens (Ags). Here, we describe a multiscale model of
Autor:
Emily R. Rhodes, B. M. Petersen, S. A. Ulmer, Timothy A. Whitehead, M. F. Gutierrez Gonzalez, Kayla G. Sprenger, Brandon J. DeKosky
Monoclonal antibodies (mAbs) are an important class of therapeutics used to treat cancer, inflammation, and infectious diseases. Identifying highly developable mAb sequences in silico could greatly reduce the time and cost required for therapeutic mA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c81b95a547e83d3df014929a20d0ff7
https://doi.org/10.1101/2021.06.22.449488
https://doi.org/10.1101/2021.06.22.449488
Autor:
Linghang Peng, Paul J. Steiner, Irene M. Francino-Urdaniz, Alison C. Leonard, Shawn Barman, Emily R. Rhodes, Cyrus M. Haas, Fangzhu Zhao, Monica B Kirby, Joseph G. Jardine, Timothy A. Whitehead, Kayla G. Sprenger
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Cell Reports
article-version (status) pre
article-version (number) 1
Cell Reports
The potential emergence of SARS-CoV-2 Spike (S) escape mutants is a threat to reduce the efficacy of existing vaccines and neutralizing antibody (nAb) therapies. An understanding of the antibody/S escape mutation landscape is urgently needed to preem
Publikováno v:
Proc Natl Acad Sci U S A
Natural infections and vaccination with a pathogen typically stimulate the production of potent antibodies specific for the pathogen through a Darwinian evolutionary process known as affinity maturation. Such antibodies provide protection against rei