Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Kayla G. Barnes"'
Autor:
Kayla G. Barnes, Joshua I. Levy, Jillian Gauld, Jonathan Rigby, Oscar Kanjerwa, Christopher B. Uzzell, Chisomo Chilupsya, Catherine Anscombe, Christopher Tomkins-Tinch, Omar Mbeti, Edward Cairns, Herbert Thole, Shannon McSweeney, Marah G. Chibwana, Philip M. Ashton, Khuzwayo C. Jere, John Scott Meschke, Peter Diggle, Jennifer Cornick, Benjamin Chilima, Kondwani Jambo, Kristian G. Andersen, Gift Kawalazira, Steve Paterson, Tonney S. Nyirenda, Nicholas Feasey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The COVID-19 pandemic has profoundly impacted health systems globally and robust surveillance has been critical for pandemic control, however not all countries can currently sustain community pathogen surveillance programs. Wastewater survei
Externí odkaz:
https://doaj.org/article/d44d0de541934d628984d02c52f9cee8
Autor:
Luisa Santus, Maria Sopena-Rios, Raquel García-Pérez, Aaron E. Lin, Gordon C. Adams, Kayla G. Barnes, Katherine J. Siddle, Shirlee Wohl, Ferran Reverter, John L. Rinn, Richard S. Bennett, Lisa E. Hensley, Pardis C. Sabeti, Marta Melé
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Long non-coding RNAs (lncRNAs) are involved in numerous biological processes and are pivotal mediators of the immune response, yet little is known about their properties at the single-cell level. Here, we generate a multi-tissue bulk RNAseq
Externí odkaz:
https://doaj.org/article/5370a6f7e4c54340b26405e7cf365b14
Acute rotavirus infection is associated with the induction of circulating memory CD4+ T cell subsets
Autor:
Chikondi Malamba-Banda, Chimwemwe Mhango, Prisca Benedicto-Matambo, Jonathan J. Mandolo, End Chinyama, Orpha Kumwenda, Kayla G. Barnes, Nigel A. Cunliffe, Miren Iturriza-Gomara, Kondwani C. Jambo, Khuzwayo C. Jere
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Strong CD4+ T cell-mediated immune protection following rotavirus infection has been observed in animal models, but its relevance in humans remains unclear. Here, we characterized acute and convalescent CD4+ T cell responses in children who
Externí odkaz:
https://doaj.org/article/f54a11022a924976af074cef85e6c85f
Autor:
Catherine Anscombe, Samantha Lissauer, Herbert Thole, Jamie Rylance, Dingase Dula, Mavis Menyere, Belson Kutambe, Charlotte van der Veer, Tamara Phiri, Ndaziona P. Banda, Kwazizira S. Mndolo, Kelvin Mponda, Chimota Phiri, Jane Mallewa, Mulinda Nyirenda, Grace Katha, Henry Mwandumba, Stephen B. Gordon, Kondwani C. Jambo, Jennifer Cornick, Nicholas Feasey, Kayla G. Barnes, Ben Morton, Philip M. Ashton, Blantyre COVID-19 Consortium
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background Compared to the abundance of clinical and genomic information available on patients hospitalised with COVID-19 disease from high-income countries, there is a paucity of data from low-income countries. Our aim was to explore the re
Externí odkaz:
https://doaj.org/article/4d8bcf03a04c4deb972cc0267183a58e
Autor:
Marah G. Chibwana, Herbert W. Thole, Cat Anscombe, Philip M. Ashton, Edward Green, Kayla G. Barnes, Jen Cornick, Ann Turner, Desiree Witte, Sharon Nthala, Chikondi Thom, Felistas Kanyandula, Anna Ainani, Natasha Mtike, Hope Tambala, Veronica N’goma, Dorah Mwafulirwa, Erick Asima, Ben Morton, Markus Gmeiner, Zaziwe Gundah, Gift Kawalazira, Neil French, Nicholas Feasey, Robert S. Heyderman, Todd D. Swarthout, Kondwani C. Jambo
Publikováno v:
PLOS Global Public Health, Vol 3, Iss 3 (2023)
The SARS-CoV-2 Omicron variant has resulted in a high number of cases, but a relatively low incidence of severe disease and deaths, compared to the pre-Omicron variants. Therefore, we assessed the differences in symptom prevalence between Omicron and
Externí odkaz:
https://doaj.org/article/366afb93d3ba4e7091f3ab0fe452397c
Autor:
Ben Morton, Kayla G. Barnes, Catherine Anscombe, Khuzwayo Jere, Prisca Matambo, Jonathan Mandolo, Raphael Kamng’ona, Comfort Brown, James Nyirenda, Tamara Phiri, Ndaziona P. Banda, Charlotte Van Der Veer, Kwazizira S. Mndolo, Kelvin Mponda, Jamie Rylance, Chimota Phiri, Jane Mallewa, Mulinda Nyirenda, Grace Katha, Paul Kambiya, James Jafali, Henry C. Mwandumba, Stephen B. Gordon, Blantyre COVID-19 Consortium, Jennifer Cornick, Kondwani C. Jambo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Clinical management of COVID-19 in resource-poor settings has distinct challenges and detailed patient characterisation is needed. Here, the authors describe the clinical and immunological profiles of patients at a hospital in Malawi with confirmed a
Externí odkaz:
https://doaj.org/article/5ac0ac388c3f4d77be678f53c3d46ebe
Autor:
Kayla G. Barnes, Anna E. Lachenauer, Adam Nitido, Sameed Siddiqui, Robin Gross, Brett Beitzel, Katherine J. Siddle, Catherine A. Freije, Bonnie Dighero-Kemp, Samar B. Mehta, Amber Carter, Jessica Uwanibe, Fehintola Ajogbasile, Testimony Olumade, Ikponmwosa Odia, John Demby Sandi, Mambu Momoh, Hayden C. Metsky, Chloe K. Boehm, Aaron E. Lin, Molly Kemball, Daniel J. Park, Luis Branco, Matt Boisen, Brian Sullivan, Mihret F. Amare, Abdulwasiu B. Tiamiyu, Zahra F. Parker, Michael Iroezindu, Donald S. Grant, Kayvon Modjarrad, Cameron Myhrvold, Robert F. Garry, Gustavo Palacios, Lisa E. Hensley, Stephen F. Schaffner, Christian T. Happi, Andres Colubri, Pardis C. Sabeti
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Outbreaks of viral hemorrhagic fevers highlight the need for sensitive, field-deployable diagnostics. Here the authors present a CRISPR-based SHERLOCK platform with field protocol and mobile app for Ebola and Lassa fever outbreaks.
Externí odkaz:
https://doaj.org/article/08e45296a0194caf8c3263c4c6cc81b0
Autor:
Sylvanus Okogbenin, Joseph Okoeguale, George Akpede, Andres Colubri, Kayla G. Barnes, Samar Mehta, Reuben Eifediyi, Felix Okogbo, Joseph Eigbefoh, Mojeed Momoh, Mojeed Rafiu, Donatus Adomeh, Ikponmwosa Odia, Chris Aire, Rebecca Atafo, Martha Okonofua, Meike Pahlman, Beate Becker-Ziaja, Danny Asogun, Peter Okokhere, Christian Happi, Stephan Günther, Pardis C. Sabeti, Ephraim Ogbaini-Emovon
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 8, Pp 1494-1500 (2019)
Lassa fever in pregnancy causes high rates of maternal and fetal death, but limited data are available to guide clinicians. We retrospectively studied 30 pregnant Lassa fever patients treated with early ribavirin therapy and a conservative obstetric
Externí odkaz:
https://doaj.org/article/e4ba3e66850f4f659119007cbca67685
Autor:
Jessica G. Shantha, John G. Mattia, Augustine Goba, Kayla G. Barnes, Faiqa K. Ebrahim, Colleen S. Kraft, Brent R. Hayek, Jessica N. Hartnett, Jeffrey G. Shaffer, John S. Schieffelin, John D. Sandi, Mambu Momoh, Simbirie Jalloh, Donald S. Grant, Kerry Dierberg, Joyce Chang, Sharmistha Mishra, Adrienne K. Chan, Rob Fowler, Tim O'Dempsey, Erick Kaluma, Taylor Hendricks, Roger Reiners, Melanie Reiners, Lowell A. Gess, Kwame ONeill, Sarian Kamara, Alie Wurie, Mohamed Mansaray, Nisha R. Acharya, William J. Liu, Sina Bavari, Gustavo Palacios, Moges Teshome, Ian Crozier, Paul E. Farmer, Timothy M. Uyeki, Daniel G. Bausch, Robert F. Garry, Matthew J. Vandy, Steven Yeh
Publikováno v:
EBioMedicine, Vol 30, Iss , Pp 217-224 (2018)
Background: Ebola virus disease (EVD) survivors are at risk for uveitis during convalescence. Vision loss has been observed following uveitis due to cataracts. Since Ebola virus (EBOV) may persist in the ocular fluid of EVD survivors for an unknown d
Externí odkaz:
https://doaj.org/article/e8eaffbbae8741d0b1198cef8981f949
Autor:
Chimwemwe Mhango, Akuzike Banda, End Chinyama, Jonathan J Mandolo, Orpha Kumwenda, Chikondi Malamba-Banda, Kayla G Barnes, Benjamin Kumwenda, Kondwani Jambo, Celeste M Donato, Mathew D Esona, Peter N Mwangi, A Duncan Steele, Miren Iturriza-Gomara, Nigel A Cunliffe, Valentine N Ndze, Arox W Kamng’ona, Francis E Dennis, Martin M Nyaga, Chrispin Chaguza, Khuzwayo C Jere
Publikováno v:
Virus Evolution.
G3 rotaviruses rank among the most common rotavirus strains worldwide in humans and animals. However, despite a robust long-term rotavirus surveillance system from 1997 at Queen Elizabeth Central Hospital in Blantyre, Malawi, these strains were only