Data from Menin-mediated Repression of Glycolysis in Combination with Autophagy Protects Colon Cancer Against Small-molecule EGFR Inhibitors

Autor: Xianxin Hua, Jian Ma, Xin He, Zijie Feng, Xuyao Zhang, Yan Cao, Katherine M. Szigety, Kayla E. Paulosky, Rebecca A. Glynn, Taylor Hojnacki, Bryson W. Katona

Menin serves both tumor suppressor and promoter roles in a highly tumor-specific manner. In colorectal cancer, menin is overexpressed and plays a critical role in regulating transcription of SKP2, and combined treatment with a menin inhibitor and sma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a695973899c4eb7472623d0ff91f67f
https://doi.org/10.1158/1535-7163.c.6542025

Data from Combined Menin and EGFR Inhibitors Synergize to Suppress Colorectal Cancer via EGFR-Independent and Calcium-Mediated Repression of SKP2 Transcription

Autor: Xianxin Hua, Donita C. Brady, Bruce D. Freedman, Xin He, Yuan Wu, Haoren Wang, Yuanyuan Liu, Smita Matkar, Katherine M. Szigety, Corbett T. Berry, Jian Ma, Caroline I. Davis, Zijie Feng, Kayla E. Paulosky, Rebecca A. Glynn, Bryson W. Katona

Menin is a nuclear epigenetic regulator that can both promote and suppress tumor growth in a highly tissue-specific manner. The role of menin in colorectal cancer, however, remains unclear. Here, we demonstrate that menin was overexpressed in colorec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::befa6fcba17e107346b518a675e30375
https://doi.org/10.1158/0008-5472.c.6511616.v1

Menin-mediated Repression of Glycolysis in Combination with Autophagy Protects Colon Cancer Against Small-molecule EGFR Inhibitors

Autor: Rebecca A Glynn, Xuyao Zhang, Yan Cao, Katherine M Szigety, Xianxin Hua, Jian Ma, Zijie Feng, Taylor Hojnacki, Kayla E Paulosky, Xin He, Bryson W. Katona

Publikováno v: Mol Cancer Ther

Menin serves both tumor suppressor and promoter roles in a highly tumor-specific manner. In colorectal cancer, menin is overexpressed and plays a critical role in regulating transcription of SKP2, and combined treatment with a menin inhibitor and sma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26aa463bfd057c0a05e82b8721049f8f
https://pubmed.ncbi.nlm.nih.gov/32879052

Menin Maintains Cholesterol Content in Colorectal Cancer via Repression of LXR-Mediated Transcription.

Autor: Nyul, Thomas E.¹ (AUTHOR), Beyries, Keely¹ (AUTHOR), Hojnacki, Taylor¹ (AUTHOR), Glynn, Rebecca¹ (AUTHOR), Paulosky, Kayla E.¹ (AUTHOR), Gedela, Anitej¹ (AUTHOR), Majer, Ariana¹ (AUTHOR), Altman, Lily¹ (AUTHOR), Buckley, Kole H.¹ (AUTHOR), Feng, Zijie² (AUTHOR) huax@pennmedicine.upenn.edu, Sun, Kunfeng² (AUTHOR), Peng, Zhicheng² (AUTHOR), Tobias, John W.³ (AUTHOR) jtobias@pennmedicine.upenn.edu, Hua, Xianxin² (AUTHOR), Katona, Bryson W.¹ (AUTHOR) bryson.katona@pennmedicine.upenn.edu

Publikováno v: Cancers. Aug2023, Vol. 15 Issue 16, p4126. 17p.

Study Findings on Colon Cancer Are Outlined in Reports from University of Pennsylvania (Menin Maintains Cholesterol Content in Colorectal Cancer via Repression of LXR-Mediated Transcription).

Publikováno v: Cancer Weekly; 9/12/2023, p1616-1616, 1p