Immunological profiles in HIV positive patients following Haart initiation in Kigali, Rwanda

Autor: Twizerimana, AP, Mwatha, J, Musabyimana, JP, Kayigi, E, De Dieu Harelimana, J, Karanja, SM, Mutesa, L

Publikováno v: East African Medical Journal; Vol 91, No 8 (2014); 261-266

Background: Interleukin-10, IL-2 and IFN -γ are some of the crucial cytokines associated with HIV infection and pathogenesis. While IL-2 and IFN-γ play critical roles in host resistance to infection, IL-10 inhibits the synthesis IFN-γ, IL-2 at mRN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=78975075580c::8917adcc71141172baa2970e1a0b576e
https://www.ajol.info/index.php/eamj/article/view/110494

Genomic and transmission dynamics of the 2024 Marburg Virus Outbreak in Rwanda.

Autor: Butera Y; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda. yvan.butera@moh.gov.rw.; Ministry of Health, Kigali, Rwanda. yvan.butera@moh.gov.rw., Mutesa L; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda. l.mutesa@ur.ac.rw.; Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda. l.mutesa@ur.ac.rw.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia. l.mutesa@ur.ac.rw., Parker E; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Muvunyi R; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Umumararungu E; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Ayitewala A; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Musabyimana JP; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Olono A; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Sesonga P; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Ogunsanya O; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Kabalisa E; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Adedokun O; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Gahima N; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Irankunda L; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Mutezemariya C; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Niyonkuru R; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Uwituze A; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Uwizera I; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Kagame J; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Umugwaneza A; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Rwabuhihi J; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Umwanankabandi F; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Mbonitegeka V; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Ntagwabira E; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Kayigi E; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Izuwayo G; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Murenzi H; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Mukankwiro T; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Tuyiringire N; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Uwimana JMV; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Gasengayire A; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Sindayiheba R; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Onyeugo GU; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Aragaw M; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Gitundu L; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Bigirimana R; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Fallah M; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Ejikeme A; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Sembuche S; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Kabanda A; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Mugisha JC; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Francis EES; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Gashema P; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Ndayisenga J; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Rugamba A; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda., Kanyabwisha F; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda., Murenzi G; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda., Happi A; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Ngabonziza JCS; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Gashegu M; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Ahmed A; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia.; Rwanda Biomedical Centre, Kigali, Rwanda., Bigirimana N; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Rwagasore E; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Semakula M; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Ministry of Health, Kigali, Rwanda., Rwabihama JP; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Ministry of Health, Kigali, Rwanda.; Department of Internal Medicine, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda., Musanabaganwa C; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Seruyange E; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Department of Internal Medicine, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda.; Rwanda Military Referral and Teaching Hospital, Kigali, Rwanda., Nkeshimana M; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Ministry of Health, Kigali, Rwanda., Twagirumugabe T; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Butare University Teaching Hospital, Huye, Rwanda., Turatsinze D; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Kigali University Teaching Hospital, Kigali, Rwanda., Remera E; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Gahamanyi N; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Tessema SK; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Africa Centre for Disease Control and Prevention, Addis Ababa, Ethiopia., Mukagatare I; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Nsanzimana S; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.; Ministry of Health, Kigali, Rwanda., Happi C; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda. happic@run.edu.ng.; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria. happic@run.edu.ng.; Department of Immunology and Infectious Diseases, Harvard T H Chan School of Public Health, Boston, MA, USA. happic@run.edu.ng., Muvunyi CM; Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda. claude.muvunyi@rbc.gov.rw.; Rwanda Biomedical Centre, Kigali, Rwanda. claude.muvunyi@rbc.gov.rw.

Publikováno v: Nature medicine [Nat Med] 2024 Dec 16. Date of Electronic Publication: 2024 Dec 16.