Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Kaye J Williams"'
Autor:
Emma J Searle, Brian A Telfer, Debayan Mukherjee, Duncan M Forster, Barry R Davies, Kaye J Williams, Ian J Stratford, Tim M Illidge
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 12, Pp 1646-1659 (2017)
Abstract Radiotherapy is an important anti‐cancer treatment, but tumour recurrence remains a significant clinical problem. In an effort to improve outcomes further, targeted anti‐cancer drugs are being tested in combination with radiotherapy. Her
Externí odkaz:
https://doaj.org/article/94b34dde6bcb4bbb88dfef6a2ecc2928
Autor:
Kenny Kwok-Hei Yu, Jessica T Taylor, Omar N Pathmanaban, Amir Saam Youshani, Deniz Beyit, Joanna Dutko-Gwozdz, Roderick Benson, Gareth Griffiths, Ian Peers, Peter Cueppens, Brian A Telfer, Kaye J Williams, Catherine McBain, Ian D Kamaly-Asl, Brian W Bigger
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193694 (2018)
Glioblastoma (GBM) is the most common primary brain malignancy in adults, yet survival outcomes remain poor. First line treatment is well established, however disease invariably recurs and improving prognosis is challenging. With the aim of personali
Externí odkaz:
https://doaj.org/article/c0919e2e2f8a4abbb588898382f3d76c
Autor:
Suzanne L Meredith, Jennifer L Bryant, Muhammad Babur, Philip W Riddell, Roya Behrouzi, Kaye J Williams, Anne White
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148404 (2016)
BACKGROUND:Small cell lung cancer (SCLC) is an extremely aggressive disease, commonly displaying therapy-resistant relapse. We have previously identified neuroendocrine and epithelial phenotypes in SCLC tumours and the neuroendocrine marker, pro-opio
Externí odkaz:
https://doaj.org/article/d7061301a8a04596a0085312b423dc97
Autor:
Simon J A van Kuijk, Roben G Gieling, Raymon Niemans, Natasja G Lieuwes, Rianne Biemans, Brian A Telfer, Guido R M M Haenen, Ala Yaromina, Philippe Lambin, Ludwig J Dubois, Kaye J Williams
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161040 (2016)
Carbonic anhydrase IX (CAIX) is a tumor-specific protein that is upregulated during hypoxic conditions where it is involved in maintaining the pH balance. CAIX causes extracellular acidification, thereby limiting the uptake of weak basic chemotherape
Externí odkaz:
https://doaj.org/article/ac88a352ecf64264b8874d1a5184899c
Autor:
Cian M McCrudden, Martin G O'Rourke, Kim E Cherry, Hiu-Fung Yuen, Declan O'Rourke, Muhammad Babur, Brian A Telfer, Huw D Thomas, Patrick Keane, Thiagarajan Nambirajan, Chris Hagan, Joe M O'Sullivan, Chris Shaw, Kaye J Williams, Nicola J Curtin, David G Hirst, Tracy Robson
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118187 (2015)
Therapeutic inhibition of poly(ADP-ribose) polymerase (PARP), as monotherapy or to supplement the potencies of other agents, is a promising strategy in cancer treatment. We previously reported that the first PARP inhibitor to enter clinical trial, ru
Externí odkaz:
https://doaj.org/article/0041870469fb4ed7ba5bba882c646e79
Autor:
Emma R. Biglin, Adam H. Aitkenhead, Gareth J. Price, Amy L. Chadwick, Elham Santina, Kaye J. Williams, Karen J. Kirkby
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Preclinical radiation research lacks standardized dosimetry procedures that provide traceability to a primary standard. Consequently, ensuring accuracy and reproducibility between studies is challenging. Using 3D printed murine phantoms we u
Externí odkaz:
https://doaj.org/article/837936469b87449c8bfd74544c4248a6
Autor:
Becky A. S. Bibby, Niluja Thiruthaneeswaran, Lingjian Yang, Ronnie R. Pereira, Elisabet More, Darragh G. McArt, Paul O’Reilly, Robert G. Bristow, Kaye J. Williams, Ananya Choudhury, Catharine M. L. West
Publikováno v:
BMC Urology, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background The presence of hypoxia is a poor prognostic factor in prostate cancer and the hypoxic tumor microenvironment promotes radioresistance. There is potential for drug radiotherapy combinations to improve the therapeutic ratio. We aim
Externí odkaz:
https://doaj.org/article/dc9fc4ab567343f7a4756b4ec9e09d1b
Autor:
Maria Likhatcheva, Roben G. Gieling, James A. L. Brown, Constantinos Demonacos, Kaye J. Williams
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The effects of genotoxic stress can be mediated by activation of the Ataxia Telangiectasia Mutated (ATM) kinase, under both DNA damage-dependent (including ionizing radiation), and independent (including hypoxic stress) conditions. ATM activation is
Externí odkaz:
https://doaj.org/article/c0666bb8a86b4bdd9b41099d7119f8ab
Autor:
Ian J. Stratford, Susan E. Critchlow, Paul D. Smith, Kaye J. Williams, Brian A. Telfer, Kathryn G. Blount, Filippos Michopoulos, Amy L. Chadwick, Becky M. Bola
This file shows the aerobic and anoxic toxicity of AZD3965.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2310b6caa33dbfec3004ae7b7846fb5c
https://doi.org/10.1158/1535-7163.22502373.v1
https://doi.org/10.1158/1535-7163.22502373.v1
Autor:
Kaye J. Williams, Ian Wilson, Duncan Hiscock, Caroline Dive, Adam McMahon, Gavin Brown, Cassandra Hodgkinson, Kathryn Simpson, Muhammad Babur, Alison Smigova, Marc Radigois, Jamil Gregory, Duncan Forster, Christopher J. Morrow, Roben G. Gieling, Natalie Burrows, Christopher Cawthorne
PDF file - 65 KB, Acute dosing with GDC-0941 leads to an increase in apoptotic signaling in in sensitive tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708657f7214f04cb186176d4644e0ee6
https://doi.org/10.1158/1535-7163.22499062
https://doi.org/10.1158/1535-7163.22499062