Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation.

Autor: Kailass K; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada L5L 1C6., Casalena D; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States., Jenane L; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada L5L 1C6., McEdwards G; Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada, L5L 1C6., Auld DS; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States., Sadovski O; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada L5L 1C6., Kaye EG; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada L5L 1C6., Hudson E; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada L5L 1C6., Nettleton D; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States., Currie MA; Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada, L5L 1C6., Beharry AA; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada L5L 1C6.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Feb 08; Vol. 67 (3), pp. 2019-2030. Date of Electronic Publication: 2024 Jan 24.

Photo-Uncaging by C(sp ³ )-C(sp ³ ) Bond Cleavage Restores β-Lapachone Activity.

Autor: Kaye EG; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario L5L 1C6, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada., Mirabi B; Department of Chemistry, Davenport Chemical Laboratories, University of Toronto, Toronto, Ontario M5S 3H6, Canada., Lopez-Miranda IR; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario L5L 1C6, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada., Dissanayake KC; Department of Chemistry, Iowa State University, Ames, Iowa 50014, United States., Banerjee U; Department of Chemistry, Iowa State University, Ames, Iowa 50014, United States., Austin M; Department of Chemistry, Iowa State University, Ames, Iowa 50014, United States., Lautens M; Department of Chemistry, Davenport Chemical Laboratories, University of Toronto, Toronto, Ontario M5S 3H6, Canada., Winter AH; Department of Chemistry, Iowa State University, Ames, Iowa 50014, United States., Beharry AA; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario L5L 1C6, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2023 Jun 14; Vol. 145 (23), pp. 12518-12531. Date of Electronic Publication: 2023 Jun 02.

Dynamic control of chromatin-associated m ⁶ A methylation regulates nascent RNA synthesis.

Autor: Xu W; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai 201399, China., He C; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai 201399, China., Kaye EG; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Li J; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai 201399, China., Mu M; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai 201399, China., Nelson GM; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Dong L; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai 201399, China., Wang J; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai 201399, China., Wu F; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai 201399, China., Shi YG; Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Adelman K; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: karen_adelman@hms.harvard.edu., Lan F; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai 201399, China. Electronic address: fei_lan@fudan.edu.cn., Shi Y; Ludwig Institute for Cancer Research, Oxford Branch, Oxford University, Oxford OX3 7DQ, UK. Electronic address: yang.shi@ludwig.ox.ac.uk., Shen H; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai 201399, China. Electronic address: hongjieshen@fudan.edu.cn.

Publikováno v: Molecular cell [Mol Cell] 2022 Mar 17; Vol. 82 (6), pp. 1156-1168.e7. Date of Electronic Publication: 2022 Feb 25.

Differential Occupancy of Two GA-Binding Proteins Promotes Targeting of the Drosophila Dosage Compensation Complex to the Male X Chromosome.

Autor: Kaye EG; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA., Booker M; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA; Department of Molecular Biology, Massachusetts General Hospital, Cambridge, MA 02114, USA., Kurland JV; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Conicella AE; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA., Fawzi NL; Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA., Bulyk ML; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Tolstorukov MY; Department of Molecular Biology, Massachusetts General Hospital, Cambridge, MA 02114, USA. Electronic address: tolstorukov@molbio.mgh.harvard.edu., Larschan E; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA. Electronic address: erica_larschan@brown.edu.

Publikováno v: Cell reports [Cell Rep] 2018 Mar 20; Vol. 22 (12), pp. 3227-3239.

Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation.

Autor: Kuzu G; Department of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, Rhode Island, United States of America.; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America., Kaye EG; Department of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, Rhode Island, United States of America., Chery J; Department of Cell Biology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America., Siggers T; Department of Biology, Boston University, Boston, Massachusetts, United States of America., Yang L; Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America., Dobson JR; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America., Boor S; Department of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, Rhode Island, United States of America., Bliss J; Department of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, Rhode Island, United States of America., Liu W; Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China., Jogl G; Department of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, Rhode Island, United States of America., Rohs R; Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America., Singh ND; Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America., Bulyk ML; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Tolstorukov MY; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America., Larschan E; Department of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, Rhode Island, United States of America.

Publikováno v: PLoS genetics [PLoS Genet] 2016 Jul 14; Vol. 12 (7), pp. e1006120. Date of Electronic Publication: 2016 Jul 14 (Print Publication: 2016).