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pro vyhledávání: '"Kaycie Butler"'
Publikováno v:
ACS Chemical Biology. 15:2907-2915
The success of phage display, used for developing target-specific binders based on peptides and proteins, depends on the size and diversity of the library screened, but generating large libraries of phage-encoded polypeptides remains challenging. New
Autor:
Bernd Stegmayr, Enza Cecere, Tamara Maric, Vanessa Carle, Junko Goto, Yuteng Wu, Rakesh Mukherjee, Xu-Dong Kong, Camille Villequey, Kaycie Butler, Quentin Laurent, Cristina Díaz-Perlas, Chloé Rogg, Christian Heinis, Christina Lamers, Madhuree S Konakalla
Publikováno v:
Journal of medicinal chemistry. 64(10)
Coagulation factor XI (FXI) has emerged as a promising target for the development of safer anticoagulation drugs that limit the risk of severe and life-threatening bleeding. Herein, we report the first cyclic peptide-based FXI inhibitor that selectiv