Zobrazeno 1 - 10
of 371
pro vyhledávání: '"Kay-Hooi Khoo"'
Autor:
Gang Wu, Paola Grassi, David A. MacIntyre, Belen Gimeno Molina, Lynne Sykes, Samit Kundu, Cheng-Te Hsiao, Kay-Hooi Khoo, Phillip R. Bennett, Anne Dell, Stuart M. Haslam
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Human cervicovaginal fluid (CVF) is a complex, functionally important and glycan rich biological fluid, fundamental in mediating physiological events associated with reproductive health. Using a comprehensive glycomic strategy we reveal an e
Externí odkaz:
https://doaj.org/article/a1f676e4234a4232b15a58c7b5f2ef25
Autor:
Cheng-Yu Huang, Piotr Draczkowski, Yong-Sheng Wang, Chia-Yu Chang, Yu-Chun Chien, Yun-Han Cheng, Yi-Min Wu, Chun-Hsiung Wang, Yuan-Chih Chang, Yen-Chen Chang, Tzu-Jing Yang, Yu-Xi Tsai, Kay-Hooi Khoo, Hui-Wen Chang, Shang-Te Danny Hsu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Hsu and co-workers integrate cryo-electron tomography, cryo-electron microscopy and mass spectrometry to reveal the structural polymorphism of a pig coronavirus spike protein within intact viral particles, and how glycosylation modulates the conforma
Externí odkaz:
https://doaj.org/article/599a00b0c1c249b28cf37be2d8eb384f
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
A 29-amino acid sequence in the N-terminal domain of LAMP-1 promotes its Lewis X glycosylation and is embeddable to other proteins for Lewis X glycoengineering.
Externí odkaz:
https://doaj.org/article/8859b6183d7c47e39ccbd4e7cf971a14
Autor:
Audrey Auger, Shin-Yi Yu, Shih-Yun Guu, Agnès Quéméner, Gabriel Euller-Nicolas, Hiromune Ando, Marion Desdouits, Françoise S. Le Guyader, Kay-Hooi Khoo, Jacques Le Pendu, Frederic Chirat, Yann Guerardel
Publikováno v:
Marine Drugs, Vol 21, Iss 6, p 342 (2023)
Noroviruses, the major cause of acute viral gastroenteritis, are known to bind to histo-blood group antigens (HBGAs), including ABH groups and Lewis-type epitopes, which decorate the surface of erythrocytes and epithelial cells of their host tissues.
Externí odkaz:
https://doaj.org/article/907fa189bde34b1e893aa52a838a8258
Autor:
Lan-Yi Chang, Suh-Yuen Liang, Shao-Chia Lu, Huan Chuan Tseng, Ho-Yang Tsai, Chin-Ju Tang, Marcelia Sugata, Yi-Ju Chen, Yu-Ju Chen, Shang-Ju Wu, Kuo-I Lin, Kay-Hooi Khoo, Takashi Angata
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Siglec-7 (sialic acid–binding immunoglobulin-like lectin 7) is an immune checkpoint-like glycan recognition protein on natural killer (NK) cells. Cancer cells often upregulate Siglec ligands to subvert immunosurveillance, but the molecular basis of
Externí odkaz:
https://doaj.org/article/c41da1f073eb457fb00cadf4cfe5d547
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Mass spectrometry–based high-sensitivity mapping of terminal glycotopes relies on diagnostic MS2 and/or MS3 ions that can differentiate linkage and define the location of substituents including sulfates. Unambiguous identification of adult zebrafis
Externí odkaz:
https://doaj.org/article/51087b993b30490a91f7ad009e59fc5f
Autor:
Fumiko Umezawa, Makoto Natsume, Shigeki Fukusada, Kazuki Nakajima, Fumiya Yamasaki, Hiroto Kawashima, Chu-Wei Kuo, Kay-Hooi Khoo, Takaya Shimura, Hirokazu Yagi, Koichi Kato
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6662 (2022)
The dystrophin–glycoprotein complex connects the cytoskeleton with base membrane components such as laminin through unique O-glycans displayed on α-dystroglycan (α-DG). Genetic impairment of elongation of these glycans causes congenital muscular
Externí odkaz:
https://doaj.org/article/b4283df908144867b7894da60a7a2d22
Autor:
Nao Yamakawa, Jorick Vanbeselaere, Lan-Yi Chang, Shin-Yi Yu, Lucie Ducrocq, Anne Harduin-Lepers, Junichi Kurata, Kiyoko F. Aoki-Kinoshita, Chihiro Sato, Kay-Hooi Khoo, Ken Kitajima, Yann Guerardel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Zebrafish is a popular system for studying the molecular basis of glycan-related human diseases. Here, the authors present glycomic profiles of eight zebrafish organs and establish the organ-specific expression patterns of related biosynthetic enzyme
Externí odkaz:
https://doaj.org/article/0893d8f6942d41d18ec00c807f00af89
Autor:
Hsuan-Hsuan Lu, Shu-Yung Lin, Rueyhung Roc Weng, Yi-Hsiu Juan, Yen-Wei Chen, Hsin-Han Hou, Zheng-Ci Hung, Giovanni Audrey Oswita, Yi-Jhen Huang, Shih-Yun Guu, Kay-Hooi Khoo, Jin-Yuan Shih, Chong-Jen Yu, Hsing-Chen Tsai
Publikováno v:
EBioMedicine, Vol 57, Iss , Pp 102846- (2020)
Background: Aberrant fucosylation plays a critical role in lung cancer progression. Nevertheless, the key fucosyltransferase with prognostic significance in lung cancer patients, the enzyme's intracellular targets, and complex molecular mechanisms un
Externí odkaz:
https://doaj.org/article/3e1f5de51bb54a53945251839bbddb2e
Publikováno v:
Bio-Protocol, Vol 10, Iss 10 (2020)
We have developed enabling techniques for sulfoglycomics based on MALDI-MS mapping and MS/MS sequencing of permethylated sulfated glycans. We then extended further the analytical workflow to C18 reverse phase (RP)-nanoLC-nanoESI-MS/MS analyses of per
Externí odkaz:
https://doaj.org/article/7b520c57045a44f9801ec64fa519d4b7