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Autor:
Prashant V Nannan Panday, Jos G. W. Kosterink, Mireille A. Wessels, Kay van Hateren, Willem Dieperink, Jan G. Zijlstra, Jan-Willem C. Alffenaar, Heleen Aardema
Publikováno v:
International journal of antimicrobial agents, 50(1), 68-73. Elsevier Bedrijfsinformatie b.v.
Optimal dosing of β-lactam antibiotics in critically ill patients is a challenge given the unpredictable pharmacokinetic profile of this patient population. Several studies have shown intermittent dosing to often yield inadequate drug concentrations