Zobrazeno 1 - 10
of 285
pro vyhledávání: '"Kay Uwe-Wagner"'
Autor:
Hridaya Shrestha, Patrick D. Rädler, Rayane Dennaoui, Madison N. Wicker, Nirakar Rajbhandari, Yunguang Sun, Amy R. Peck, Kerry Vistisen, Aleata A. Triplett, Rafic Beydoun, Esta Sterneck, Dieter Saur, Hallgeir Rui, Kay-Uwe Wagner
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114202- (2024)
Summary: Interleukin-6 (IL-6)-class inflammatory cytokines signal through the Janus tyrosine kinase (JAK)/signal transducer and activator of transcription (STAT) pathway and promote the development of pancreatic ductal adenocarcinoma (PDAC); however,
Externí odkaz:
https://doaj.org/article/e616b34f78d94a48bb4d9c1f4d4b7fda
Autor:
Jennifer B. Jacob, Kuang-Chung Wei, Gerold Bepler, Joyce D. Reyes, Andi Cani, Lisa Polin, Kathryn White, Seongho Kim, Nerissa Viola, Julie McGrath, Anthony Guastella, CongCong Yin, Qing-Shen Mi, Benjamin L. Kidder, Kay-Uwe Wagner, Stuart Ratner, Victoria Phillips, Joanne Xiu, Prahlad Parajuli, Wei-Zen Wei
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106320- (2023)
Summary: HER2-targeted therapy has improved breast cancer survival, but treatment resistance and disease prevention remain major challenges. Genes that enable HER2/Neu oncogenesis are the next intervention targets. A bioinformatics discovery platform
Externí odkaz:
https://doaj.org/article/ef28e19612ea43f89c00bb93371e0760
Autor:
Madison N. Wicker, Kay-Uwe Wagner
Publikováno v:
Cancers, Vol 15, Iss 23, p 5605 (2023)
Cellular plasticity is a phenomenon where cells adopt different identities during development and tissue homeostasis as a response to physiological and pathological conditions. This review provides a general introduction to processes by which cells c
Externí odkaz:
https://doaj.org/article/51a240307ab04358bb613d5e7eeebcfb
Autor:
Idit Dotan, Jiaqi Yang, Jiro Ikeda, Ziv Roth, Evan Pollock-Tahiri, Harsh Desai, Tharini Sivasubramaniyam, Sonia Rehal, Josh Rapps, Yu Zhe Li, Helen Le, Gedaliah Farber, Edouard Alchami, Changting Xiao, Saraf Karim, Marcela Gronda, Michael F. Saikali, Amit Tirosh, Kay-Uwe Wagner, Jacques Genest, Aaron D. Schimmer, Vikas Gupta, Mark D. Minden, Carolyn L. Cummins, Gary F. Lewis, Clinton Robbins, Jenny Jongstra-Bilen, Myron Cybulsky, Minna Woo
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Loss of myeloid JAK2 promotes atherosclerosis in an ApoE knockout mouse model. This is associated with decreased cholesterol efflux from bone-marrow-derived macrophages.
Externí odkaz:
https://doaj.org/article/8f5bbf65f53546318be8781e62cd0a46
Autor:
Patrick D. Rädler, Kerry Vistisen, Aleata A. Triplett, Rayane Dennaoui, Yong Li, Hridaya Shrestha, Rosa-Maria Ferraiuolo, Amalraj Thangasamy, Dieter Saur, Kay-Uwe Wagner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract We developed a transgenic mouse line that expresses the codon-optimized Flp recombinase under the control of the MMTV promoter in luminal epithelial cells of the mammary gland. In this report, we demonstrate the versatile applicability of th
Externí odkaz:
https://doaj.org/article/34a21ee56ad94549b07db0526b9bc2dd
Publikováno v:
Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-17 (2021)
Abstract Background The tumor susceptibility gene 101 (Tsg101), a component of the endosomal sorting complex required for transport (ESCRT) complex I, is involved in multiple biological processes involving endomembranous structures and the plasma mem
Externí odkaz:
https://doaj.org/article/0509f27121e34df4ab90a9ad8aed4420
Autor:
Patrick D. Rädler, Barbara L. Wehde, Aleata A. Triplett, Hridaya Shrestha, Jonathan H. Shepherd, Adam D. Pfefferle, Hallgeir Rui, Robert D. Cardiff, Charles M. Perou, Kay-Uwe Wagner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The cellular origin and oncogenic drivers promoting claudin-low breast cancer are undefined. Here, the authors report that the consistent activation of oncogenic RAS signaling, as well as regulators of EMT, play a crucial role in the cellular plastic
Externí odkaz:
https://doaj.org/article/73b3b931199c4ef2944a84166e09403e
Autor:
Kay-Uwe Wagner
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/3579cc32149d4dcfbe5c6d914a77a650
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
GPCRs are highly desirable drug targets for human disease. Although GPCR dysfunction drives development and progression of many tumors, including breast cancer (BC), targeting individual GPCRs has limited efficacy as a cancer therapy because numerous
Externí odkaz:
https://doaj.org/article/e847b129bf434051bc84d8e6abd7ee2b
Autor:
Asfar S. Azmi, Ramzi M. Mohammad, Philip A. Philip, Bassel F. El-Rayes, Nerissa T. Viola, Kay-Uwe Wagner, Yosef Landesman, William T. Senapedis, Erkan Baloglu, Gregory Dyson, Rafic Beydoun, Steve H. Kim, Yiwei Li, Amro Aboukameel, Mohammed N. Al-Hallak, Md. Hafiz Uddin, Gabriel B. Mpilla
Metastatic pancreatic neuroendocrine tumors (PNET) remain an unmet clinical problem. Chronologic treatment in PNETs includes observation (watchful protocol), surgery, targeted therapy, and chemotherapy. However, increasing evidence illustrates that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174f2675208c5e838760dd90c77538d9
https://doi.org/10.1158/1535-7163.c.6542856.v1
https://doi.org/10.1158/1535-7163.c.6542856.v1