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Interaction sites of the Epstein–Barr virus Zta transcription factor with the host genome in epithelial cells

Autor: Alison J. Sinclair, Anja Godfrey, Kay Osborn

Publikováno v: Access Microbiology

Epstein–Barr virus (EBV) is present in a state of latency in infected memory B-cells and EBV-associated lymphoid and epithelial cancers. Cell stimulation or differentiation of infected B-cells and epithelial cells induces reactivation to the lytic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b727aff1c5a12f35151df304e6b641
https://doi.org/10.1099/acmi.0.000282

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Identifying the Cellular Interactome of Epstein-Barr Virus Lytic Regulator Zta Reveals Cellular Targets Contributing to Viral Replication

Autor: Rajaei Almohammed, Alison J. Sinclair, Yaqi Zhou, Steve M. M. Sweet, Kay Osborn, Kate J. Heesom

Publikováno v: J Virol
Zhou, Y, Heesom, K, Osborn, K, Almohammad, R, Sweet, S M & Sinclair, A J 2020, ' Identifying the Cellular Interactome of Epstein-Barr Virus Lytic Regulator Zta Reveals Cellular Targets Contributing to Viral Replication ', Journal of Virology . https://doi.org/10.1128/JVI.00927-19

The human gamma herpesvirus Epstein-Barr virus (EBV; HHV4), infects most adults and is an important contributor to the development of many types of lymphoid and epithelial cancers. Essential contributions of viral genes to viral replication are known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369fe770d4262e8111bfabb3648befa8
https://europepmc.org/articles/PMC7000981/

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Mechanism of activation of the BNLF2a immune evasion gene of Epstein-Barr virus by Zta

Autor: Rajaei, Almohammed, Kay, Osborn, Sharada, Ramasubramanyan, Ijiel Barak Naranjo, Perez-Fernandez, Anja, Godfrey, Erika J, Mancini, Alison J, Sinclair

Publikováno v: The Journal of General Virology

The human gamma herpes virus Epstein–Barr virus (EBV) exploits multiple routes to evade the cellular immune response. During the EBV lytic replication cycle, viral proteins are expressed that provide excellent targets for recognition by cytotoxic T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d7c2b6999cb0ecf81dac6ef5647d6a5
https://pubmed.ncbi.nlm.nih.gov/29580369

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Abstract 2907: Targeting the epigenetic regulator KAT2a in cancer

Autor: Darren Le Grand, Jessica Hudson, Hitesh Patel, Simon E. Ward, Andrea Gunnell, Lewis E. Pennicott, Katie Duffell, Jessica A. Downs, Jessica R Booth, Kay Osborn

Publikováno v: Cancer Research. 78:2907-2907

Gene expression frequently requires the dynamic remodelling of the chromatin architecture to orchestrate the assembly of transcriptional protein complexes at the promoter sites of DNA. Chromatin remodelling complexes are multicomponent proteins that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65316d5effbdf4c1fef8ab9a4393b480
https://doi.org/10.1158/1538-7445.am2018-2907

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Epstein-Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression

Autor: Sharada, Ramasubramanyan, Kay, Osborn, Rajaei, Al-Mohammad, Ijiel B, Naranjo Perez-Fernandez, Jianmin, Zuo, Nicolae, Balan, Anja, Godfrey, Harshil, Patel, Gordon, Peters, Martin, Rowe, Richard G, Jenner, Alison J, Sinclair

Publikováno v: Nucleic Acids Research

Lytic replication of the human gamma herpes virus Epstein-Barr virus (EBV) is an essential prerequisite for the spread of the virus. Differential regulation of a limited number of cellular genes has been reported in B-cells during the viral lytic rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15492a425efca6a35500d3500b8adbda
https://pubmed.ncbi.nlm.nih.gov/25779048

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Genome-Wide Analyses of Zta Binding to the Epstein-Barr Virus Genome Reveals Interactions in both Early and Late Lytic Cycles and an Epigenetic Switch Leading to an Altered Binding Profile

Autor: Kay Osborn, Alison J. Sinclair, Aditi Kanhere, Richard G. Jenner, Sharada Ramasubramanyan, Kirsty Flower

The Epstein-Barr virus (EBV) genome sustains substantial epigenetic modification involving chromatin remodelling and DNA methylation during lytic replication. Zta (ZEBRA, BZLF1), a key regulator of the EBV lytic cycle, is a transcription and replicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79196c4bfb1873531d535905772bc207
https://europepmc.org/articles/PMC3497672/

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Dynamic chromatin environment of key lytic cycle regulatory regions of the Epstein-Barr virus genome

Autor: Kirsty Flower, Kay Osborn, Alison J. Sinclair, Sharada Ramasubramanyan

The ability of Epstein-Barr virus (EBV) to establish latency allows it to evade the immune system and to persist for the lifetime of its host; one distinguishing characteristic is the lack of transcription of the majority of viral genes. Entry into t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5416efc8a437174faa1685a90141bb5f

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A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

Autor: Kay Osborn, Keith W. Caldecott, Maria C. Zuma, Felipe Cortes Ledesma, Sherif F. El Khamisy

Publikováno v: Nature. 461(7264)

Topoisomerases regulate DNA topology and are fundamental to many aspects of chromosome metabolism. Their activity involves the transient cleavage of DNA, which, if it occurs near sites of endogenous DNA damage or in the presence of topoisomerase pois

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9edfec15ed95778dee879d1402ac13f5
https://pubmed.ncbi.nlm.nih.gov/19794497

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