Zobrazeno 1 - 10
of 278
pro vyhledávání: '"Kay Ohlendieck"'
Autor:
Paul Dowling, Stephen Gargan, Margit Zweyer, Michael Henry, Paula Meleady, Dieter Swandulla, Kay Ohlendieck
Publikováno v:
European Journal of Translational Myology (2024)
During the natural aging process, frailty is often associated with abnormal muscular performance. Although inter-individual differences exit, in most elderly the tissue mass and physiological functionality of voluntary muscles drastically decreases.
Externí odkaz:
https://doaj.org/article/91111fcdbc4f4b1098689f59316a5367
Autor:
Paul Dowling, Stephen Gargan, Margit Zweyer, Michael Henry, Paula Meleady, Dieter Swandulla, Kay Ohlendieck
Publikováno v:
European Journal of Translational Myology (2024)
Sarcopenia of old age is characterized by the progressive loss of skeletal muscle mass and concomitant decrease in contractile strength. Age-related skeletal muscle dysfunctions play a key pathophysiological role in the frailty syndrome and can resul
Externí odkaz:
https://doaj.org/article/e471eb9effea4ca5bcd3bad522cd5177
Publikováno v:
European Journal of Translational Myology (2024)
It is with great sadness that we learned of the passing of Prof. Dr. Dr. h.c. Dirk Pette. He passed away suddenly and unexpectedly on June 4, 2022. Dirk was an outstanding professor of biochemistry at the University of Konstanz, Germany and an intern
Externí odkaz:
https://doaj.org/article/6cae03c9d6064b1da0136e81398560a9
Publikováno v:
European Journal of Translational Myology (2023)
Duchenne muscular dystrophy is a highly progressive muscle wasting disease of early childhood and characterized by complex pathophysiological and histopathological changes in the voluntary contractile system, including myonecrosis, chronic inflammati
Externí odkaz:
https://doaj.org/article/dc87d351c7e544bd9dd1278e992fec0e
Publikováno v:
Proteomes, Vol 12, Iss 1, p 4 (2024)
This perspective article is concerned with the question of how proteomics, which is a core technique of systems biology that is deeply embedded in the multi-omics field of modern bioresearch, can help us better understand the molecular pathogenesis o
Externí odkaz:
https://doaj.org/article/d136680472f449ee963e203b4c7920d8
Autor:
Sandra Murphy, Thomas Schmitt-John, Paul Dowling, Michael Henry, Paula Meleady, Dieter Swandulla, Kay Ohlendieck
Publikováno v:
European Journal of Translational Myology (2023)
The wobbler mouse is a widely used model system of amyotrophic lateral sclerosis and exhibits progressive neurodegeneration and neuroinflammation in association with skeletal muscle wasting. This study has used wobbler brain preparations for the syst
Externí odkaz:
https://doaj.org/article/14a15df723f242ac9dee9db1d1360029
Autor:
Paul Dowling, Margit Zweyer, Hemmen Sabir, Michael Henry, Paula Meleady, Dieter Swandulla, Kay Ohlendieck
Publikováno v:
European Journal of Translational Myology (2023)
Neuromuscular diseases with primary muscle wasting symptoms may also display multi-systemic changes in the body and exhibit secondary pathophysiological alterations in various non-muscle tissues. In some cases, this includes proteome-wide alterations
Externí odkaz:
https://doaj.org/article/736dd3a5367f46079af7f7b51c985935
Publikováno v:
Cells, Vol 12, Iss 21, p 2560 (2023)
Voluntary striated muscles are characterized by a highly complex and dynamic proteome that efficiently adapts to changed physiological demands or alters considerably during pathophysiological dysfunction. The skeletal muscle proteome has been extensi
Externí odkaz:
https://doaj.org/article/c512c05b3b5c4ef6821c92fca579832e
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1108 (2023)
The progressive degeneration of the skeletal musculature in Duchenne muscular dystrophy is accompanied by reactive myofibrosis, fat substitution, and chronic inflammation. Fibrotic changes and reduced tissue elasticity correlate with the loss in moto
Externí odkaz:
https://doaj.org/article/30051471b1344621bcbd41db74e045ba
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2415 (2023)
The progressive loss of skeletal muscle mass and concomitant reduction in contractile strength plays a central role in frailty syndrome. Age-related neuronal impairments are closely associated with sarcopenia in the elderly, which is characterized by
Externí odkaz:
https://doaj.org/article/784e484a993243e5b4a0d82f3633d3bf