Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kay O. Chmielewski"'
Autor:
Ron Baik, M. Kyle Cromer, Steve E. Glenn, Christopher A. Vakulskas, Kay O. Chmielewski, Amanda M. Dudek, William N. Feist, Julia Klermund, Suzette Shipp, Toni Cathomen, Daniel P. Dever, Matthew H. Porteus
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Genome editing by homology directed repair (HDR) is leveraged to precisely modify the genome of therapeutically relevant hematopoietic stem and progenitor cells (HSPCs). Here, we present a new approach to increasing the frequency of HDR in h
Externí odkaz:
https://doaj.org/article/4a155dde2a4841efb751cb4ae1cb657c
Autor:
Jamal Alzubi, Dominik Lock, Manuel Rhiel, Sabrina Schmitz, Stefan Wild, Claudio Mussolino, Markus Hildenbeutel, Caroline Brandes, Julia Rositzka, Simon Lennartz, Simone A. Haas, Kay O. Chmielewski, Thomas Schaser, Andrew Kaiser, Toni Cathomen, Tatjana I. Cornu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 379-388 (2021)
The potential of adoptive cell therapy can be extended when combined with genome editing. However, variation in the quality of the starting material and the different manufacturing steps are associated with production failure and product contaminatio
Externí odkaz:
https://doaj.org/article/e8aa757ae0ec4109904f3108d8338f68
Autor:
Benjamin C. Houghton, Neelam Panchal, Simone A. Haas, Kay O. Chmielewski, Markus Hildenbeutel, Thomas Whittaker, Claudio Mussolino, Toni Cathomen, Adrian J Thrasher, Claire Booth
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
X-linked lymphoproliferative disease is a rare inherited immune disorder, caused by mutations or deletions in the SH2D1A gene that encodes an intracellular adapter protein SAP (Slam-associated protein). SAP is essential for mediating several key immu
Externí odkaz:
https://doaj.org/article/e1802e6cee45487398ad67ff6d224f5a
Autor:
Jamal Alzubi, Dominik Lock, Manuel Rhiel, Sabrina Schmitz, Stefan Wild, Claudio Mussolino, Markus Hildenbeutel, Caroline Brandes, Julia Rositzka, Simon Lennartz, Simone A. Haas, Kay O. Chmielewski, Thomas Schaser, Andrew Kaiser, Toni Cathomen, Tatjana I. Cornu
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 379-388 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 379-388 (2021)
The potential of adoptive cell therapy can be extended when combined with genome editing. However, variation in the quality of the starting material and the different manufacturing steps are associated with production failure and product contaminatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a779b2250fe12157bafba6a3112b08be
http://europepmc.org/articles/PMC7848723
http://europepmc.org/articles/PMC7848723
Autor:
Benjamin C. Houghton, Neelam Panchal, Simone A. Haas, Kay O. Chmielewski, Markus Hildenbeutel, Thomas Whittaker, Claudio Mussolino, Toni Cathomen, Adrian J Thrasher, Claire Booth
Publikováno v:
Frontiers in genome editing. 4
X-linked lymphoproliferative disease is a rare inherited immune disorder, caused by mutations or deletions in the SH2D1A gene that encodes an intracellular adapter protein SAP (Slam-associated protein). SAP is essential for mediating several key immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46b11746ecdc90f81efcf0cc95302ec
https://pubmed.ncbi.nlm.nih.gov/35677600
https://pubmed.ncbi.nlm.nih.gov/35677600
Autor:
Kristie Bloom, Tiffany S. Smith, Prashika Singh, Patrick Arbuthnot, Abdullah Ely, Kay O. Chmielewski, Toni Cathomen
Publikováno v:
Viruses
Volume 13
Issue 7
Viruses, Vol 13, Iss 1344, p 1344 (2021)
Volume 13
Issue 7
Viruses, Vol 13, Iss 1344, p 1344 (2021)
Persistent hepatitis B virus (HBV) infection remains a serious medical problem worldwide, with an estimated global burden of 257 million carriers. Prophylactic and therapeutic interventions, in the form of a vaccine, immunomodulators, and nucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28bc8d74e0294090774d323e52617eb7
Autor:
Jamal Alzubi, Patrick Arbuthnot, Laura Mosti, Lukas M. Langner, Kay O. Chmielewski, Toni Cathomen
Publikováno v:
Gene Therapy
Chimeric antigen receptor (CAR) T cell technology has enabled successfully novel concepts to treat cancer patients, with substantial remission rates in lymphoid malignancies. This cell therapy is based on autologous T lymphocytes that are genetically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9247142765c6c1b6c19e62a17c3ee29
https://pubmed.ncbi.nlm.nih.gov/33526841
https://pubmed.ncbi.nlm.nih.gov/33526841