Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Kay Lin Goh"'
1
2-Anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1
Autor: Chang Kai Soh, Kay Lin Goh, Meredith Williams, Kantharaj Ethirajulu, Haishan Wang, Zahid Bonday, Jeanette Marjorie Wood, Miah Kiat Goh, Kee Chuan Goh, Brian Dymock, Anders Poulsen, Stéphanie Blanchard, Mohammed Khalid Pasha, Chai Ping Lee
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:2880-2884
A series of 2-anilino substituted 4-aryl-8H-purines were prepared as potent inhibitors of PDK1, a serine-threonine kinase thought to play a role in the PI3K/Akt signaling pathway, a key mediator of cancer cell growth, survival and tumorigenesis. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e326a1e8754536639d26a7d08fc874
https://doi.org/10.1016/j.bmcl.2012.02.058
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3
Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors
Autor: Anders Poulsen, Kee Chuan Goh, Ee Ling Teo, Chee Pang Ng, Stéphanie Blanchard, Evelyn Tan, Wai Chung Ong, Kay Lin Goh, Weiping Deng, Angeline C.-H. Lee, Eric T. Sun, Anthony D. William, Noah Tu, Zahid Bonday
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:2443-2447
A series of alkenyl indazoles were synthesized and evaluated in Aurora kinase enzyme assays. Several promising leads were optimized for selectivity towards Aurora B. Excellent binding affinity and good selectivity were achieved with optimized compoun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3804e131a7790015f35bf5b404ddd9ce
https://doi.org/10.1016/j.bmcl.2010.03.018
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4
Ardisiaquinones from Ardisia teysmanniana
Autor: Yee-Hing Lai, Lay-Kien Yang, K. Yoganathan, Mark S. Butler, Bee-Lee Chng, Kay-Lin Goh, Corinne Khoo-Beattie
Publikováno v: Phytochemistry. 58:1235-1238
Bioassay-guided fractionation of a CHCl3 extract from the leaves of Ardisia teysmanniana Scheff. (Myrsinaceae) has led to the isolation of three new alkyldibenzoquinone derivatives that showed inhibitory activity in an in vitro assay for UDP-MurNac s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a53b4e0f07327073c1d2a7e5356e56c
https://doi.org/10.1016/s0031-9422(01)00317-x
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5
Identification of a Plasmodium berghei antigen sharing common features with P. falciparum and P. chabaudi parasitophorous-vacuole membrane antigens
Autor: U. A. K. Kara, Robert C. Ting, Le Nugyen Binh, Kay Lin Goh, Theresa M.C. Tan
Publikováno v: Parasitology Research. 82:130-135
On the basis of immunological cross-reactivity, we identified a 43-kDa Plasmodium berghei antigen with homology to the exp-1 antigen from P. falciparium. The P. berghei antigen was recognized by an antibody directed against an epitope on the C-termin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8960187d23b2dd2879ddeb3db6eb2ab3
https://doi.org/10.1007/s004360050083
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6
Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening
Autor: Brian Dymock, Diana M. Ma, Anders Poulsen, Miah Kiat Goh, Kee Chuan Goh, Kay Lin Goh, Jeanette Marjorie Wood, Meredith Williams, Stéphanie Blanchard, Pondy Murugappan Ramanujulu, Angeline C.-H. Lee, Zahid Bonday
Publikováno v: Bioorganicmedicinal chemistry letters. 22(12)
Ligand efficient fragments binding to PDK1 were identified by an NMR fragment-based screening approach. Computational modeling of the fragments bound to the active site led to the design and synthesis of a series of novel 6,7-disubstituted thienopyri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3860d683d40d4999a854d07700ac145d
https://pubmed.ncbi.nlm.nih.gov/22591730
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7
Structure-based design of Aurora AB inhibitors
Autor: Angeline Lee, Evelyn Tan, Kay Lin Goh, Eric T. Sun, Anthony D. William, Wai Chung Ong, Kee Chuan Goh, Weiping Deng, Stéphanie Blanchard, Eeling Teo, Anders Poulsen, Chee Pang Ng, Noah Tu, Zahid Bonday
Publikováno v: Journal of computer-aided molecular design. 22(12)
The Aurora family of serine/threonine kinases are mitotic regulators involved in centrosome duplication, formation of the bipolar mitotic spindle and the alignment of the chromosomes along the spindle. These proteins are frequently overexpressed in t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575e7486a0fde2742bcb2123c838ef4c
https://pubmed.ncbi.nlm.nih.gov/18574696
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9
Abstract 3564: Design, synthesis and SAR studies leading to SB1518, a novel macrocyclic JAK2/FLT3 inhibitor in phase 2 clinical trials for myelofibrosis and lymphoma
Autor: Mohammed Khalid Pasha, Kee Chuan Goh, Harish Kumar Mysore Nagaraj, Kay Lin Goh, Ramesh Jayaraman, Kantharaj Ethirajulu, Evelyn Tan, Anders Poulsen, Brian W. Dymock, Jeanette Marjorie Wood, Angeline Lee, Anthony D. William, Wai Chung Ong
Publikováno v: Cancer Research. 71:3564-3564
Introduction: Here we present the unique chemical structure of SB1518 and SAR studies leading to the discovery of this exciting novel JAK2/FLT3 inhibitor, currently in clinical trials for myelofibrosis and lymphoma. Methods/Results: As part of our in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd9b405d9826908af8b184528e163c57
https://doi.org/10.1158/1538-7445.am2011-3564
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