Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Kay L. Double"'
Autor:
Benjamin G. Trist, Jennifer A. Fifita, Alison Hogan, Natalie Grima, Bradley Smith, Claire Troakes, Caroline Vance, Christopher Shaw, Safa Al-Sarraj, Ian P. Blair, Kay L. Double
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Multiple neurotoxic proteinopathies co-exist within vulnerable neuronal populations in all major neurodegenerative diseases. Interactions between these pathologies may modulate disease progression, suggesting they may constitute targets for
Externí odkaz:
https://doaj.org/article/6009cd789000488891a5da5a25f5909a
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract The Bradford Hill model evaluates the causal inference of one variable on another by assessing whether evidence of the suspected causal variable aligns with a set of nine criteria proposed by Bradford Hill, each representing fundamental tene
Externí odkaz:
https://doaj.org/article/5bcfbed266bc4ea58c4afce7e0cd8331
Autor:
Louis C. Penning, Marina Berenguer, Anna Czlonkowska, Kay L. Double, Petr Dusek, Carmen Espinós, Svetlana Lutsenko, Valentina Medici, Wiebke Papenthin, Wolfgang Stremmel, Jose Willemse, Ralf Weiskirchen
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 420 (2023)
Wilson disease (WD) is a rare, inherited metabolic disorder manifested with varying clinical presentations including hepatic, neurological, psychiatric, and ophthalmological features, often in combination. Causative mutations in the ATP7B gene result
Externí odkaz:
https://doaj.org/article/acc995f2df7b45f3959c8fccf8a57327
Autor:
Jacqueline Shehadeh, Kay L. Double, Karen E. Murphy, Larisa Bobrovskaya, Stefanie Reyes, Peter R. Dunkley, Glenda M. Halliday, Phillip W. Dickson
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104524- (2019)
Tyrosine hydroxylase is the key enzyme controlling the synthesis of the catecholamines including dopamine. The breakdown of dopamine into toxic compounds has been suggested to have a key role in the degeneration of the dopaminergic neurons in Parkins
Externí odkaz:
https://doaj.org/article/9c2ed183cbfe49b9b4a0b1484f716687
Autor:
Theresa N. T. Dang, Carol Dobson-Stone, Elias N. Glaros, Woojin S. Kim, Marianne Hallupp, Lauren Bartley, Olivier Piguet, John R. Hodges, Glenda M. Halliday, Kay L. Double, Peter R. Schofield, Peter J. Crouch, John B. J. Kwok
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 5, Pp 1198-1204 (2013)
SUMMARY Frontotemporal dementia (FTD) is associated with motor neurone disease (FTD-MND), corticobasal syndrome (CBS) and progressive supranuclear palsy syndrome (PSPS). Together, this group of disorders constitutes a major cause of young-onset demen
Externí odkaz:
https://doaj.org/article/652819affd724e67a4c39f977e1db999
Autor:
Gabrielle Todd, Caroline D. Rae, Janet L. Taylor, Nigel C. Rogasch, Jane E. Butler, Michael Hayes, Robert A. Wilcox, Simon C. Gandevia, Karl Aoun, Adrian Esterman, Simon J. G. Lewis, Julie M. Hall, Elie Matar, Jana Godau, Daniela Berg, Christian Plewnia, Anna‐Katharina von Thaler, Clarence Chiang, Kay L. Double
Publikováno v:
Journal of Neuroscience Research. 101:263-277
Substantia nigra (SN) hyperechogenicity, viewed with transcranial ultrasound, is a risk marker for Parkinson's disease. We hypothesized that SN hyperechogenicity in healthy adults aged 50–70 years is associated with reduced short-interval intracort
Autor:
Glenda M. Halliday, Benjamin G. Trist, Asuncion Carmona, Gerald Falkenberg, Stéphane Roudeau, Richard Ortega, Stéphane Claverol, Stijn Van Malderen, Katherine M. Davies, Yann Rufin, Kay L. Double
Publikováno v:
Analytical Chemistry
Analytical Chemistry, American Chemical Society, 2021, 93 (32), pp.11108-11115. ⟨10.1021/acs.analchem.1c01128⟩
Analytical chemistry 93(32), 11108-11115 (2021). doi:10.1021/acs.analchem.1c01128
Analytical Chemistry, American Chemical Society, 2021, 93 (32), pp.11108-11115. ⟨10.1021/acs.analchem.1c01128⟩
Analytical chemistry 93(32), 11108-11115 (2021). doi:10.1021/acs.analchem.1c01128
Analytical chemistry 93(32), 11108 - 11115 (2021). doi:10.1021/acs.analchem.1c01128
Studies of the metal content of metalloproteins in tissues from the human central nervous system (CNS) can be compromised by preparative techniques which alter l
Studies of the metal content of metalloproteins in tissues from the human central nervous system (CNS) can be compromised by preparative techniques which alter l
Iron has a long and storied history in Parkinson disease and related disorders. This essential micronutrient is critical for normal brain function, but abnormal brain iron accumulation has been associated with extrapyramidal disease for a century. Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d8f3e8c67b0c3efdd76a75f20519eb
https://hdl.handle.net/10453/163644
https://hdl.handle.net/10453/163644
Publikováno v:
Angewandte Chemie (International Ed. in English)
Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide breakdown and is important for most forms of eukaryotic life. The evolution of aerobic respiration by mitochondria increased cellular production of superoxide,
Publikováno v:
Handbook of Neurotoxicity ISBN: 9783031150791
Handbook of Neurotoxicity ISBN: 9783030715199
Handbook of Neurotoxicity
Handbook of Neurotoxicity ISBN: 9781461458357
Handbook of Neurotoxicity ISBN: 9783030715199
Handbook of Neurotoxicity
Handbook of Neurotoxicity ISBN: 9781461458357
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1137768625ba4b39fcf85283dee3173a
https://doi.org/10.1007/978-3-031-15080-7_100
https://doi.org/10.1007/978-3-031-15080-7_100