Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kay Klausing"'
Autor:
Mark D. Leibowitz, Anne Reifel-Miller, Mason E. Brooks, Rosemary Cesario, Louise Y. de Grandpre, Kay Klausing, Heidi R. Kast-Woelbern, Li Sun, Sharon L. Dana, Deborah L. Osburn
Publikováno v:
Journal of Biological Chemistry. 279:23908-23915
Insulin-induced gene 1 (INSIG-1) is a key regulator in the processing of the sterol regulatory element-binding proteins (SREBPs). We demonstrated that Insig-1 is regulated by peroxisome proliferator-activated receptor gamma (PPARgamma) providing a li
Autor:
Mary S. Urcan, Christopher M. Mapes, Marilyn Wardlow, Kathleen M. Ogilvie, Margaret M. Faul, Carol L. Broderick, Jennifer D'Arrigo, Nancy I. Hein, Mark D. Leibowitz, Marcus F. Boehm, Anne Reifel-Miller, Mark A. Carfagna, John S. Tyhonas, Deepa Rungta, Henry Havel, Dale E. Mais, Timothy Alan Grese, Sha Liu, Robert Ardecky, Bernadette Pascual, Keith B. Marschke, Nathan Yumibe, Chahrzad Montrose-Rafizadeh, Kay Klausing, Pierre-Yves Michellys, Diane L. Crombie, Richard A. Heyman, Diane Jolley, Garrett J. Etgen
Publikováno v:
Endocrinology. 147(2)
Specific retinoid X receptor (RXR) agonists, such as LG100268 (LG268), and the thiazolidinedione (TZD) PPARgamma agonists, such as rosiglitazone, produce insulin sensitization in rodent models of insulin resistance and type 2 diabetes. In sharp contr
Autor:
Curtis M, Tyree, Kay, Klausing
Publikováno v:
Methods in molecular medicine. 85
Autor:
Mark D. Leibowitz, Kay Klausing, Bernadette Pascual, Diane Jolley, Mary S. Urcan, Sha Liu, Danmei Li, James M. Bilakovics, Mark A. Lawson, Kathleen M. Ogilvie, Nancy I. Hein
Publikováno v:
Endocrinology. 143(8)
The retinoid X receptor (RXR) agonist bexarotene can cause clinically significant hypothyroidism in cutaneous T cell lymphoma patients. The mechanism by which the RXR agonist produces this effect is unclear. We have studied the impact of a selective
Autor:
Deepa Rungta, Deepak S. Lala, Kay Klausing, Rosemary Cesario, Haleh Razzaghi, Richard A. Heyman, Diane L. Crombie
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 15(8)
The RXR serves as a heterodimer partner for the PPARgamma and the dimer is a molecular target for insulin sensitizers such as the thiazolidinediones. Ligands for either receptor can activate PPAR-dependent pathways via PPAR response elements. Unlike
Autor:
Patricia A. Hoener, James R. Paterniti, Kay Klausing, Ranjan Mukherjee, Glenn Croston, Amy Faulkner, Dale E. Mais, James M. Bilakovics, Lily Jow
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 14(9)
Peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists such as the thiazolidinediones are insulin sensitizers used in the treatment of type 2 diabetes. These compounds induce adipogenesis in cell culture models and increase weight gain
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 951:388-395
Simian Virus 40 (SV40)-encoded large T antigen has an intrinsic ATP-dependent DNA-unwinding activity which is necessary for an early step in the activation of the viral origin of replication. Isolated T antigen unwinds any double-stranded DNA, regard
Publikováno v:
Journal of virology. 62(4)
Simian virus 40 large T antigen is a phosphoprotein with two clusters of phosphorylation sites. Each cluster includes four serine residues and one threonine residue. In vitro treatment with intestinal alkaline phosphatase removes the phosphate groups
Publikováno v:
Biochemistry. 28(5)
According to earlier genetic experiments, a region within the N-terminal 50-100 amino acids may be important for the replication function of T antigen, the initiator protein of simian virus 40 (SV40). We have investigated this possibility using the T